دورية أكاديمية
أعرض في EDS

Design and Characterization of Ethosomes for Transdermal Delivery of Caffeic Acid.

التفاصيل البيبلوغرافية
العنوان: Design and Characterization of Ethosomes for Transdermal Delivery of Caffeic Acid.
المؤلفون: Hallan SS; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.; Biofilms-Research Center for Biointerfaces, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden., Sguizzato M; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Mariani P; Department of Life and Environmental Sciences, Polytechnic University of Marche, I-60131 Ancona, Italy., Cortesi R; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Huang N; CNRS, Institut Galien Paris-Saclay, Université Paris-Saclay, 92296 Châtenay-Malabry, France., Simelière F; CNRS, Institut Galien Paris-Saclay, Université Paris-Saclay, 92296 Châtenay-Malabry, France., Marchetti N; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy., Drechsler M; Bavarian Polymer Institute (BPI) Keylab 'Electron and Optical Microscopy' University of Bayreuth, D-95440 Bayreuth, Germany., Ruzgas T; Biofilms-Research Center for Biointerfaces, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden., Esposito E; Department of Chemical and Pharmaceutical Sciences, University of Ferrara, I-44121 Ferrara, Italy.
المصدر: Pharmaceutics [Pharmaceutics] 2020 Aug 06; Vol. 12 (8). Date of Electronic Publication: 2020 Aug 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: The present investigation describes a formulative study aimed at designing ethosomes for caffeic acid transdermal administration. Since caffeic acid is characterized by antioxidant potential but also high instability, its encapsulation appears to be an interesting strategy. Ethosomes were produced by adding water into a phosphatidylcholine ethanol solution under magnetic stirring. Size distribution and morphology of ethosome were investigated by photon correlation spectroscopy, small-angle X-ray spectroscopy, and cryogenic transmission electron microscopy, while the entrapment capacity of caffeic acid was evaluated by high-performance liquid chromatography. Caffeic acid stability in ethosome was compared to the stability of the molecule in water, determined by mass spectrometry. Ethosome dispersion was thickened by poloxamer 407, obtaining an ethosomal gel that was characterized for rheological behavior and deformability. Caffeic acid diffusion kinetics were determined by Franz cells, while its penetration through skin, as well as its antioxidant activity, were evaluated using a porcine skin membrane-covered biosensor based on oxygen electrode. Ethosome mean diameter was ≈200 nm and almost stable within three months. The entrapment of caffeic acid in ethosome dramatically prolonged drug stability with respect to the aqueous solution, being 77% w / w in ethosome after six months, while in water, an almost complete degradation occurred within one month. The addition of poloxamer slightly modified vesicle structure and size, while it decreased the vesicle deformability. Caffeic acid diffusion coefficients from ethosome and ethosome gel were, respectively, 137- and 33-fold lower with respect to the aqueous solution. At last, the caffeic acid permeation and antioxidant power of ethosome were more intense with respect to the simple solution.
References: J Photochem Photobiol B. 2020 Apr;205:111846. (PMID: 32151785)
Food Chem. 2014 Dec 1;164:551-5. (PMID: 24996369)
Sensors (Basel). 2019 May 23;19(10):. (PMID: 31126113)
Mater Sci Eng C Mater Biol Appl. 2013 Jan 1;33(1):411-8. (PMID: 25428089)
J Eur Acad Dermatol Venereol. 2018 May;32(5):692-703. (PMID: 29114938)
Nanomaterials (Basel). 2020 May 18;10(5):. (PMID: 32443503)
Molecules. 2020 Mar 23;25(6):. (PMID: 32210106)
J Food Drug Anal. 2016 Oct;24(4):695-702. (PMID: 28911606)
J Phys Chem B. 2010 Jun 24;114(24):8056-60. (PMID: 20507136)
J Control Release. 2000 Apr 3;65(3):403-18. (PMID: 10699298)
Int J Nanomedicine. 2016 May 25;11:2279-304. (PMID: 27307730)
Eur J Pharm Biopharm. 2012 Feb;80(2):306-14. (PMID: 22061262)
Carcinogenesis. 2009 Feb;30(2):321-30. (PMID: 19073879)
Colloids Surf B Biointerfaces. 2020 Jan 1;185:110613. (PMID: 31715454)
Int J Biochem Cell Biol. 2007;39(1):44-84. (PMID: 16978905)
Curr Opin Pediatr. 2019 Aug;31(4):509-514. (PMID: 31188167)
Lancet. 2015 Sep 5;386(9997):983-94. (PMID: 26025581)
Curr Pharm Des. 2019;25(21):2323-2337. (PMID: 31584367)
J Microencapsul. 2015;32(8):804-10. (PMID: 26444314)
AAPS PharmSciTech. 2016 Dec;17(6):1468-1476. (PMID: 26842800)
Colloids Surf B Biointerfaces. 2020 Sep;193:111122. (PMID: 32498002)
Int J Pharm. 2014 Jan 2;460(1-2):280-8. (PMID: 24269286)
Eur J Pharm Biopharm. 2014 Nov;88(3):998-1004. (PMID: 25257714)
AAPS PharmSciTech. 2007 Dec 21;8(4):E111. (PMID: 18181532)
Eur J Pharm Sci. 2013 Mar 12;48(4-5):628-36. (PMID: 23295582)
Int J Oncol. 2018 Apr;52(4):1071-1080. (PMID: 29532857)
Recent Pat Anticancer Drug Discov. 2015;10(2):224-32. (PMID: 25619199)
Arch Dermatol Res. 2010 Mar;302(2):71-83. (PMID: 19898857)
Biosens Bioelectron. 2017 Jul 15;93:9-13. (PMID: 28073620)
Biophys J. 2010 Jan 6;98(1):147-57. (PMID: 20085727)
Int J Mol Sci. 2016 Feb 18;17(2):160. (PMID: 26901191)
Antioxidants (Basel). 2020 Jun 03;9(6):. (PMID: 32503293)
Crit Rev Ther Drug Carrier Syst. 2003;20(1):63-102. (PMID: 12911264)
Drug Dev Ind Pharm. 2006 Jan;32(1):63-72. (PMID: 16455605)
Curr Pharm Des. 2019;25(21):2338-2348. (PMID: 31333087)
J Photochem Photobiol B. 2009 Jun 3;95(3):196-203. (PMID: 19386510)
Pharmaceutics. 2011 Nov 04;3(4):793-829. (PMID: 24309309)
Int J Pharm. 2006 Sep 28;322(1-2):60-6. (PMID: 16806755)
J Agric Food Chem. 2014 Feb 26;62(8):1832-8. (PMID: 24527961)
Toxicology. 2006 Jan 16;217(2-3):213-20. (PMID: 16243424)
Colloids Surf B Biointerfaces. 2018 Mar 1;163:184-191. (PMID: 29294420)
J Pharm Sci. 2010 Jun;99(6):2819-29. (PMID: 20039387)
Arzneimittelforschung. 2000 Jan;50(1):72-6. (PMID: 10683719)
Biomaterials. 2013 Apr;34(12):3098-109. (PMID: 23375392)
AAPS PharmSciTech. 2007 Dec 14;8(4):E107. (PMID: 18181528)
Anal Chim Acta. 2019 Oct 10;1075:91-97. (PMID: 31196427)
Langmuir. 2007 Apr 24;23(9):5085-92. (PMID: 17375940)
معلومات مُعتمدة: 20170058 and 20190010 Knowledge Foundation; Collaborative Research Centre SFB 840 German Research Foundation; FAR 2019 and FIR 2019 University of Ferrara (Italy)
فهرسة مساهمة: Keywords: caffeic acid; ethosome; in vitro diffusion; oxygen electrode; penetration enhancers
تواريخ الأحداث: Date Created: 20200813 Latest Revision: 20200928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7465088
DOI: 10.3390/pharmaceutics12080740
PMID: 32781717
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics12080740