دورية أكاديمية
أعرض في EDS

Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia.

التفاصيل البيبلوغرافية
العنوان: Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia.
المؤلفون: Mietus CJ; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Lackner TJ; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Karvelis PS; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Willcockson GT; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Shields CM; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Lambert NG; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Koutakis P; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA.; Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA., Fuglestad MA; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Hernandez H; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., Haynatzki GR; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE 68198-4375, USA., Kim JKS; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA., DeSpiegelaere HK; Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105-1873, USA., Pipinos II; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA.; Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105-1873, USA., Casale GP; Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA.
المصدر: Journal of clinical medicine [J Clin Med] 2020 Aug 08; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50-150 μm) remodeling, and collagenous investment of terminal micro-vessels (diameter ≤ 15 µm) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this study, we evaluate the hypothesis that the vascular pathology associated with the legs of PAD patients encompasses pathologic changes to the smallest micro-vessels in calf muscle. Biopsies were collected from the calf muscle of control subjects and patients with Fontaine Stage II and Stage IV PAD. Slide specimens were evaluated by Quantitative Multi-Spectral and Fluorescence Microscopy. Inter-myofiber collagen, stained with Masson Trichrome (MT), was increased in Stage II patients, and more substantially in Stage IV patients in association with collagenous thickening of terminal micro-vessel walls. Evaluation of the Basement Membrane (BM) of these vessels reveals increased thickness in Stage II patients, and increased thickness, diameter, and Collagen I deposition in Stage IV patients. Coverage of these micro-vessels with pericytes, key contributors to fibrosis and BM remodeling, was increased in Stage II patients, and was greatest in Stage IV patients. Vascular pathology of the legs of PAD patients extends beyond atherosclerotic main inflow arteries and affects the entire vascular tree-including the smallest micro-vessels.
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معلومات مُعتمدة: R01 AG049868 United States AG NIA NIH HHS; R01 AG034995 and R01 AG049868 United States NH NIH HHS
فهرسة مساهمة: Keywords: basement membrane thickening; fibrosis; microvascular pathology; αSMA+ pericytes
تواريخ الأحداث: Date Created: 20200814 Latest Revision: 20210803
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7464726
DOI: 10.3390/jcm9082575
PMID: 32784470
قاعدة البيانات: MEDLINE
الوصف
تدمد:2077-0383
DOI:10.3390/jcm9082575