دورية أكاديمية
Exploration of Alternative Scaffolds for P2Y 14 Receptor Antagonists Containing a Biaryl Core.
العنوان: | Exploration of Alternative Scaffolds for P2Y |
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المؤلفون: | Jung YH; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Yu J; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Wen Z; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Salmaso V; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Karcz TP; Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, North Carolina 27709, United States.; Jagiellonian University, Kraków31-007, Poland., Phung NB; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Chen Z; Department of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, Missouri 63104, United States., Duca S; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Bennett JM; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Dudas S; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Salvemini D; Department of Pharmacology and Physiology and the Henry and Amelia Nasrallah Center for Neuroscience, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, Missouri 63104, United States., Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States., Cook DN; Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, North Carolina 27709, United States., Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States. |
المصدر: | Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 9563-9589. Date of Electronic Publication: 2020 Aug 06. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
مواضيع طبية MeSH: | Drug Design*, Purinergic P2 Receptor Antagonists/*chemistry , Purinergic P2 Receptor Antagonists/*pharmacology , Receptors, Purinergic P2/*metabolism , Triazoles/*chemistry , Triazoles/*pharmacology, Animals ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Mice ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Neuralgia/drug therapy ; Protein Conformation ; Purinergic P2 Receptor Antagonists/metabolism ; Purinergic P2 Receptor Antagonists/therapeutic use ; Receptors, Purinergic P2/chemistry ; Solubility ; Structure-Activity Relationship ; Triazoles/metabolism ; Triazoles/therapeutic use |
مستخلص: | Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y |
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معلومات مُعتمدة: | Z01 DK031126 United States ImNIH Intramural NIH HHS; HHSN271200800025C United States MH NIMH NIH HHS; ZIA DK031116 United States ImNIH Intramural NIH HHS; Z01 DK031116 United States ImNIH Intramural NIH HHS; ZIA ES102025 United States ImNIH Intramural NIH HHS |
المشرفين على المادة: | 0 (P2Y14 receptor, human) 0 (Purinergic P2 Receptor Antagonists) 0 (Receptors, Purinergic P2) 0 (Triazoles) |
تواريخ الأحداث: | Date Created: 20200814 Date Completed: 20201211 Latest Revision: 20210911 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8040948 |
DOI: | 10.1021/acs.jmedchem.0c00745 |
PMID: | 32787142 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-4804 |
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DOI: | 10.1021/acs.jmedchem.0c00745 |