دورية أكاديمية
أعرض في EDS

Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.

التفاصيل البيبلوغرافية
العنوان: Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
المؤلفون: Del-Río-Ibisate N; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Oviedo, Spain.; Ciber de Cáncer, CIBERONC, Madrid, Spain., Granda-Díaz R; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Oviedo, Spain.; Ciber de Cáncer, CIBERONC, Madrid, Spain., Rodrigo JP; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Oviedo, Spain.; Ciber de Cáncer, CIBERONC, Madrid, Spain., Menéndez ST; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Oviedo, Spain. sofiatirados@gmail.com.; Ciber de Cáncer, CIBERONC, Madrid, Spain. sofiatirados@gmail.com., García-Pedrero JM; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, IUOPA, Universidad de Oviedo, Oviedo, Spain. juanagp.finba@gmail.com.; Ciber de Cáncer, CIBERONC, Madrid, Spain. juanagp.finba@gmail.com.
المصدر: Reviews of physiology, biochemistry and pharmacology [Rev Physiol Biochem Pharmacol] 2021; Vol. 181, pp. 375-427.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0434624 Publication Model: Print Cited Medium: Print ISSN: 0303-4240 (Print) Linking ISSN: 03034240 NLM ISO Abbreviation: Rev Physiol Biochem Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Head and Neck Neoplasms*, Biomarkers, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Ion Channels/genetics ; Prognosis ; Squamous Cell Carcinoma of Head and Neck
مستخلص: Head and neck cancers are a highly complex and heterogeneous group of malignancies that involve very diverse anatomical structures and distinct aetiological factors, treatments and clinical outcomes. Among them, head and neck squamous cell carcinomas (HNSCC) are predominant and the sixth most common cancer worldwide with still low survival rates. Omic technologies have unravelled the intricacies of tumour biology, harbouring a large diversity of genetic and molecular changes to drive the carcinogenesis process. Nonetheless, this remarkable heterogeneity of molecular alterations opens up an immense opportunity to discover novel biomarkers and develop molecular-targeted therapies. Increasing evidence demonstrates that dysregulation of ion channel expression and/or function is frequently and commonly observed in a variety of cancers from different origin. As a consequence, the concept of ion channels as potential membrane therapeutic targets and/or biomarkers for cancer diagnosis and prognosis has attracted growing attention. This chapter intends to comprehensively and critically review the current state-of-art ion channel dysregulation specifically focusing on head and neck cancers and to formulate the major challenges and research needs to translate this knowledge into clinical application. Based on current reported data, various voltage-gated potassium (K v ) channels (i.e. K v 3.4, K v 10.1 and K v 11.1) have been found frequently aberrantly expressed in HNSCC as well as precancerous lesions and are highlighted as clinically and biologically relevant features in both early stages of tumourigenesis and late stages of disease progression. More importantly, they also emerge as promising candidates as cancer risk markers, tumour markers and potential anti-proliferative and anti-metastatic targets for therapeutic interventions; however, the oncogenic properties seem to be independent of their ion-conducting function.
(© 2020. Springer Nature Switzerland AG.)
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فهرسة مساهمة: Keywords: Cancer risk marker; Head and neck cancers; Ion channel; Prognostic marker; Squamous cell carcinoma; Therapeutic target
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Ion Channels)
تواريخ الأحداث: Date Created: 20200814 Date Completed: 20220104 Latest Revision: 20220531
رمز التحديث: 20221213
DOI: 10.1007/112_2020_38
PMID: 32789787
قاعدة البيانات: MEDLINE
الوصف
تدمد:0303-4240
DOI:10.1007/112_2020_38