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Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress-induced behavioral and neurochemical changes.

التفاصيل البيبلوغرافية
العنوان: Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress-induced behavioral and neurochemical changes.
المؤلفون: Flores NP; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Bona NP; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Luduvico KP; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Cardoso JS; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Soares MSP; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Gamaro GD; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Spanevello RM; Laboratório de Neuroquímica, Inflamação e Câncer, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Lencina CL; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil., Gazal M; Programa de Biologia Celular e Molecular-Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Stefanello FM; Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade Federal de Pelotas, Pelotas, Brazil.
المصدر: Journal of food biochemistry [J Food Biochem] 2020 Oct; Vol. 44 (10), pp. e13442. Date of Electronic Publication: 2020 Aug 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 7706045 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-4514 (Electronic) Linking ISSN: 01458884 NLM ISO Abbreviation: J Food Biochem Subsets: PubMed not MEDLINE; MEDLINE
أسماء مطبوعة: Publication: 2008- : Hoboken, NJ : Wiley
Original Publication: Westport, Conn. : Food & Nutrition Press
مستخلص: The aim of the current study was to evaluate the effect of chronic administration of Eugenia uniflora fruit extract on behavioral parameters, oxidative stress markers, and acetylcholinesterase activity in an animal model of depression, which was induced by chronic unpredictable stress (CUS). Mice were divided into six groups as follows: control/vehicle (water), control/fluoxetine (20 mg/kg), control/extract (200 mg/kg), CUS/vehicle, CUS/fluoxetine (20 mg/kg), and CUS/extract (200 mg/kg). Animals of the CUS group were exposed to a series of stressors for a period of 21 days. Vehicle, fluoxetine, and hydroalcoholic extract were administered daily by gavage. Results showed that E. uniflora treatment: (a) prevented the depressant-like effect induced by CUS; (b) regulated the activity of acetylcholinesterase; (c) reduced oxidative damage to lipids and reactive oxygen species production, in the prefrontal cortex and hippocampus; and (d) prevented the reduction of glutathione peroxidase in the hippocampus of animals subjected to CUS protocol. Taken together, our findings suggested that E. uniflora extract exerts a neuroprotective effect by preventing oxidative damage and decreasing CUS-induced acetylcholinesterase activity, thus, ameliorating depressive-type behavior. PRACTICAL APPLICATIONS: E. uniflora fruit extract revealed an antidepressant-like effect and prevented the oxidative damage as well as cholinergic alterations caused by chronic stress in mice. Therefore, we believe that the results obtained in this study can be used to develop an alternative therapy for the management of depressive disorders.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: acetylcholinesterase; depression; native Brazilian fruit; neuroprotective; oxidative damage
تواريخ الأحداث: Date Created: 20200818 Latest Revision: 20240805
رمز التحديث: 20240806
DOI: 10.1111/jfbc.13442
PMID: 32803896
قاعدة البيانات: MEDLINE
الوصف
تدمد:1745-4514
DOI:10.1111/jfbc.13442