دورية أكاديمية
What Awaits on the Other Side: Post-Lung Transplant Morbidity and Mortality After Pre-Transplant Hospitalization.
| العنوان: | What Awaits on the Other Side: Post-Lung Transplant Morbidity and Mortality After Pre-Transplant Hospitalization. |
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| المؤلفون: | Rudym D; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Benvenuto L; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Costa J; Department of Surgery, Columbia University Medical Center, New York, NY, USA., Aversa M; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Robbins H; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Shah L; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Kim H; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA., Stanifer BP; Department of Surgery, Columbia University Medical Center, New York, NY, USA., Sonett J; Department of Surgery, Columbia University Medical Center, New York, NY, USA., D'Ovidio F; Department of Surgery, Columbia University Medical Center, New York, NY, USA., Arcasoy SM; Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York, NY, USA. |
| المصدر: | Annals of transplantation [Ann Transplant] 2020 Aug 18; Vol. 25, pp. e922641. Date of Electronic Publication: 2020 Aug 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Scientific Literature, Inc Country of Publication: United States NLM ID: 9802544 Publication Model: Electronic Cited Medium: Internet ISSN: 2329-0358 (Electronic) Linking ISSN: 14259524 NLM ISO Abbreviation: Ann Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013- > : Smithtown, New York: International Scientific Literature, Inc. Original Publication: Warsaw : Polish Transplantology Foundation : Transplantation Institute, Warsaw Medical School, 1996- |
| مواضيع طبية MeSH: | Transplant Recipients*, Lung Diseases/*surgery , Lung Transplantation/*adverse effects , Lung Transplantation/*mortality, Adult ; Aged ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Patient Outcome Assessment ; Prognosis ; Retrospective Studies ; Survival Rate ; Waiting Lists |
| مستخلص: | BACKGROUND Morbidity and mortality rates after lung transplantation remain high compared to other solid organ transplants. In the lung allocation score era, patients given the highest priority on the waitlist are those with the greatest severity of illness, who often require preoperative hospitalization. MATERIAL AND METHODS To determine the association of pre-transplant hospitalization with post-transplant outcomes, we retrospectively evaluated 448 lung transplant recipients at our center between January 2010 and July 2017 (114 hospitalized; 334 outpatient). RESULTS Survival was similar between the groups (hazard ratio 0.93 [95% CI 0.61 to 1.42], p=0.738). However, hospitalized patients had longer hospital and intensive care unit length of stay compared to outpatients - 25 vs. 18 days, (p<0.001) and 9.5 vs. 6 days, (p<0.001), respectively. Hospitalized patients had higher rates of Grade 3 primary graft dysfunction - 29.8% vs. 9.6%, p<0.001 - and remained mechanically ventilated longer - 6 vs. 3 days, p<0.001. A greater percentage of hospitalized patients needed a tracheostomy and a re-operation within 30 days - 39.5% vs. 15.3% (p<0.001) and 22.8% vs. 12.0% (p=0.005) - respectively. After discharge, 28% of hospitalized patients required acute rehabilitation compared with 12% of outpatients (p=0.001). CONCLUSIONS While pre-transplant hospitalization is not associated with mortality, it is associated with significant morbidity after transplant. |
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| تواريخ الأحداث: | Date Created: 20200819 Date Completed: 20210701 Latest Revision: 20210701 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7453747 |
| DOI: | 10.12659/AOT.922641 |
| PMID: | 32807766 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2329-0358 |
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| DOI: | 10.12659/AOT.922641 |