دورية أكاديمية
TNF, IL-6, and IL-10 cytokines levels and their polymorphisms in renal function and time after transplantation.
| العنوان: | TNF, IL-6, and IL-10 cytokines levels and their polymorphisms in renal function and time after transplantation. |
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| المؤلفون: | Alves LV; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy - Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Martins SR; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy - Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Simões E Silva AC; Department of Pediatrics, Faculty of Medicine - Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Cardoso CN; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy - Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Gomes KB; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy - Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Mota APL; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy - Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil. analucasmota@gmail.com. |
| المصدر: | Immunologic research [Immunol Res] 2020 Oct; Vol. 68 (5), pp. 246-254. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Print Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totawa Nj : Humana Press Original Publication: Basel ; New York : S. Karger, [c1986- |
| مواضيع طبية MeSH: | Graft Rejection/*diagnosis , Interleukin-10/*blood , Interleukin-6/*blood , Kidney Transplantation/*adverse effects , Tumor Necrosis Factor-alpha/*genetics, Adult ; Alleles ; Allografts/immunology ; Allografts/physiopathology ; Biomarkers/blood ; Brazil ; Female ; Gene Frequency ; Glomerular Filtration Rate/physiology ; Graft Rejection/blood ; Graft Rejection/genetics ; Graft Rejection/immunology ; Humans ; Interleukin-10/genetics ; Interleukin-6/genetics ; Kidney/immunology ; Kidney/physiopathology ; Kidney Failure, Chronic/surgery ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Postoperative Period ; Time Factors ; Tumor Necrosis Factor-alpha/blood |
| مستخلص: | Cytokine polymorphisms can influence their plasma levels and thus affect the immune response in renal transplantation. A total of 146 renal transplant recipients (RTR) were classified into groups according to the estimated glomerular filtration rate (R1: < 60 and R2: ≥ 60 mL/min/1.73 m 2 ) and time after transplantation (T1: 1 to 24, T2: 25 to 60, T3: 61 to 120, and T4: > 120 months after transplantation). The polymorphisms were genotyped by single specific primer-polymerase chain reaction. IL-10 was measured by ELISA and IL-6, and TNF levels were determined using Miliplex®. A higher frequency of the - 308G allele and the - 308G/G genotype, low-producer, was observed in the R1 group compared with R2. In addition, a higher frequency of the - 308A carriers, high-producer, was found in the R2 group. However, no significant difference was observed in cytokine levels when both groups were compared. Higher levels of IL-6 were observed in T1 compared with T2 and T4 groups. Lower IL-6 levels were found in T2 compared with T3 group. Lower levels of IL-10 were also found in T1 group in relation to T2, while higher levels of this cytokine were observed in T2 group compared with T3. The results suggest that the - 308G > A polymorphism in the TNF gene is associated with filtration function after renal transplantation, and IL-6 and IL-10 levels change according to the time after transplantation. Thus, the joint evaluation of - 308G > A polymorphism in TNF gene and IL-6 and IL-10 levels would provide a broader and effective view on the clinical monitoring of RTR. |
| فهرسة مساهمة: | Keywords: Biomarker; Cytokines; Genetic polymorphisms; Kidney transplantation |
| المشرفين على المادة: | 0 (Biomarkers) 0 (IL10 protein, human) 0 (IL6 protein, human) 0 (Interleukin-6) 0 (TNF protein, human) 0 (Tumor Necrosis Factor-alpha) 130068-27-8 (Interleukin-10) |
| تواريخ الأحداث: | Date Created: 20200819 Date Completed: 20210823 Latest Revision: 20210823 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s12026-020-09147-3 |
| PMID: | 32808189 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1559-0755 |
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| DOI: | 10.1007/s12026-020-09147-3 |