دورية أكاديمية
أعرض في EDS

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs.

التفاصيل البيبلوغرافية
العنوان: Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs.
المؤلفون: Wienke J; Center for Translational Immunology., Brouwers L; Wilhelmina Children's Hospital Birth Center., van der Burg LM; Center for Translational Immunology., Mokry M; Regenerative Medicine Utrecht.; Laboratory of Clinical Chemistry and Hematology, and., Scholman RC; Center for Translational Immunology., Nikkels PG; Department of Pathology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Netherlands., van Rijn BB; Wilhelmina Children's Hospital Birth Center.; Obstetrics and Fetal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands., van Wijk F; Center for Translational Immunology.
المصدر: JCI insight [JCI Insight] 2020 Sep 17; Vol. 5 (18). Date of Electronic Publication: 2020 Sep 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]-
مواضيع طبية MeSH: Adaptation, Physiological*, Fetus/*metabolism , Lymphocytes, Tumor-Infiltrating/*immunology , Neoplasms/*pathology , Placenta/*metabolism , T-Lymphocytes, Regulatory/*immunology , Uterus/*metabolism, Cesarean Section ; Female ; Fetus/immunology ; Humans ; Lymphocytes, Tumor-Infiltrating/metabolism ; Maternal-Fetal Exchange ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Placenta/immunology ; Pregnancy ; T-Lymphocytes, Regulatory/metabolism ; Transcriptome ; Uterus/immunology
مستخلص: Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy. Uterine biopsies, from placental bed (materno-fetal interface) and incision site (control) and blood were obtained from women with uncomplicated pregnancies undergoing cesarean section. Tregs and CD4+ non-Tregs were isolated for transcriptomic profiling by Cel-Seq2. Results were validated on protein and single cell levels by flow cytometry. Placental bed uTregs showed elevated expression of Treg signature markers, including FOXP3, CTLA-4, and TIGIT. Their transcriptional profile was indicative of late-stage effector Treg differentiation and chronic activation, with increased expression of immune checkpoints GITR, TNFR2, OX-40, and 4-1BB; genes associated with suppressive capacity (HAVCR2, IL10, LAYN, and PDCD1); and transcription factors MAF, PRDM1, BATF, and VDR. uTregs mirrored non-Treg Th1 polarization and tissue residency. The particular transcriptional signature of placental bed uTregs overlapped strongly with that of tumor-infiltrating Tregs and was remarkably pronounced at the placental bed compared with uterine control site. In conclusion, human uTregs acquire a differentiated effector Treg profile similar to tumor-infiltrating Tregs, specifically at the materno-fetal interface. This introduces the concept of site-specific transcriptional adaptation of Tregs within 1 organ.
References: Nat Immunol. 2004 Mar;5(3):266-71. (PMID: 14758358)
J Exp Med. 2007 Jun 11;204(6):1335-47. (PMID: 17548521)
Immunol Cell Biol. 2011 Mar;89(3):417-25. (PMID: 20733594)
Cancer Immunol Res. 2016 Sep 2;4(9):721-5. (PMID: 27590281)
Mucosal Immunol. 2018 May;11(3):654-667. (PMID: 29139478)
Nat Rev Immunol. 2014 Mar;14(3):154-65. (PMID: 24481337)
Science. 2015 Aug 28;349(6251):989-93. (PMID: 26160380)
Sci Immunol. 2016 Aug 26;1(2):eaaf7471. (PMID: 28783695)
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7219-24. (PMID: 26015573)
Mucosal Immunol. 2016 Mar;9(2):444-57. (PMID: 26307665)
Nat Med. 2009 Aug;15(8):930-9. (PMID: 19633656)
Immunity. 2018 May 15;48(5):1046-1059.e6. (PMID: 29752063)
J Immunol. 2008 Apr 15;180(8):5737-45. (PMID: 18390759)
Nat Rev Immunol. 2016 May;16(5):295-309. (PMID: 27087661)
Am J Reprod Immunol. 2016 Jul;76(1):3-7. (PMID: 27293114)
Front Immunol. 2018 Oct 11;9:2165. (PMID: 30364244)
Am J Clin Exp Immunol. 2018 Oct 05;7(5):81-87. (PMID: 30498624)
Nature. 2009 Mar 19;458(7236):351-6. (PMID: 19182775)
Cell Rep. 2017 Sep 19;20(12):2921-2934. (PMID: 28930685)
Am J Reprod Immunol. 2011 Jul;66 Suppl 1:44-56. (PMID: 21726337)
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1111-20. (PMID: 24610777)
Nucleic Acids Res. 2002 Jan 1;30(1):207-10. (PMID: 11752295)
Leukemia. 2014 Oct;28(10):2016-27. (PMID: 24577531)
Adv Immunol. 2016;132:1-46. (PMID: 27769505)
Front Immunol. 2018 Aug 24;9:1934. (PMID: 30197648)
J Clin Invest. 2007 May;117(5):1175-83. (PMID: 17476347)
Sci Immunol. 2019 Mar 8;4(33):. (PMID: 30850393)
Nat Immunol. 2015 Mar;16(3):276-85. (PMID: 25599561)
Annu Rev Immunol. 2016 May 20;34:609-33. (PMID: 27168246)
Nat Med. 2016 Jan;22(1):72-7. (PMID: 26657141)
Bioinformatics. 2010 Mar 1;26(5):589-95. (PMID: 20080505)
Oncotarget. 2018 Nov 16;9(90):36166-36184. (PMID: 30546835)
J Immunol. 2010 Jul 15;185(2):1071-81. (PMID: 20554955)
J Clin Invest. 2011 Nov;121(11):4503-15. (PMID: 21965331)
Cell. 2018 Aug 23;174(5):1293-1308.e36. (PMID: 29961579)
Science. 2009 Nov 13;326(5955):986-91. (PMID: 19797626)
Cell Rep. 2017 Jul 18;20(3):757-770. (PMID: 28723576)
J Immunol. 2009 May 1;182(9):5488-97. (PMID: 19380797)
Am J Reprod Immunol. 2007 Jul;58(1):39-45. (PMID: 17565546)
Front Immunol. 2014 Jun 19;5:294. (PMID: 24995010)
Immunology. 2004 May;112(1):38-43. (PMID: 15096182)
J Autoimmun. 2018 Jul;91:73-82. (PMID: 29724515)
J Clin Invest. 2013 Mar;123(3):939-44. (PMID: 23454755)
J Clin Invest. 2009 Jul;119(7):2062-73. (PMID: 19546507)
Cell Rep. 2017 Sep 19;20(12):2906-2920. (PMID: 28889989)
Nat Rev Immunol. 2010 Jul;10(7):490-500. (PMID: 20559327)
Immunity. 2014 Apr 17;40(4):569-81. (PMID: 24745333)
Arthritis Rheumatol. 2016 Jan;68(1):229-36. (PMID: 26360332)
Diabetes. 2015 Jun;64(6):2172-83. (PMID: 25576057)
Nat Immunol. 2009 Aug;10(8):857-63. (PMID: 19578369)
J Immunol. 2017 Nov 15;199(10):3406-3417. (PMID: 28986438)
Mol Hum Reprod. 2006 May;12(5):301-8. (PMID: 16574699)
Immunity. 2016 Nov 15;45(5):1122-1134. (PMID: 27851913)
Nat Immunol. 2016 Dec;17(12):1467-1478. (PMID: 27776108)
Cell Physiol Biochem. 2008;21(5-6):463-72. (PMID: 18453754)
Immunity. 2009 Mar 20;30(3):458-69. (PMID: 19303390)
Clin Exp Immunol. 2007 Jul;149(1):139-45. (PMID: 17459078)
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10672-E10681. (PMID: 30348759)
Eur J Immunol. 2007 Apr;37(4):978-89. (PMID: 17345581)
Immunity. 2008 Jun;28(6):870-80. (PMID: 18513999)
Blood. 2005 Nov 1;106(9):3300-7. (PMID: 16002422)
Nat Rev Immunol. 2017 Aug;17(8):469-482. (PMID: 28627518)
Cell. 2014 Nov 6;159(4):814-28. (PMID: 25417158)
Nat Immunol. 2017 Oct;18(10):1160-1172. (PMID: 28783152)
J Immunol. 2013 Sep 1;191(5):2273-81. (PMID: 23913969)
Cold Spring Harb Perspect Biol. 2019 Mar 1;11(3):. (PMID: 29101106)
Immunity. 2017 Aug 15;47(2):268-283.e9. (PMID: 28778586)
Nat Immunol. 2017 Feb;18(2):173-183. (PMID: 27992401)
Nat Immunol. 2019 Apr;20(4):386-396. (PMID: 30890797)
Nat Immunol. 2015 Feb;16(2):197-206. (PMID: 25501630)
Front Immunol. 2018 Apr 25;9:883. (PMID: 29887862)
Immunity. 2019 Feb 19;50(2):493-504.e7. (PMID: 30737144)
Cell. 2015 Aug 27;162(5):1078-89. (PMID: 26317471)
Immunity. 2012 Sep 21;37(3):511-23. (PMID: 22981537)
Mayo Clin Proc. 2009 Nov;84(11):985-1000. (PMID: 19880689)
Immunity. 2016 Nov 15;45(5):1135-1147. (PMID: 27851914)
Nat Immunol. 2009 Jun;10(6):595-602. (PMID: 19412181)
Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):14103-14108. (PMID: 27872297)
Front Immunol. 2018 Jun 13;9:1344. (PMID: 29951069)
Sci Immunol. 2018 Sep 14;3(27):. (PMID: 30217811)
Nature. 2002 Nov 21;420(6913):265-6. (PMID: 12447413)
Nature. 2012 Jun 28;486(7404):549-53. (PMID: 22722857)
Nat Med. 2011 Jun;17(6):673-5. (PMID: 21540856)
PLoS One. 2011 Jan 26;6(1):e16245. (PMID: 21298112)
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517)
Immunity. 2013 Jan 24;38(1):187-97. (PMID: 23260195)
Clin Immunol. 2009 Dec;133(3):402-10. (PMID: 19766059)
J Immunol. 2009 Dec 1;183(11):7023-30. (PMID: 19915051)
Nature. 2012 Oct 4;490(7418):102-6. (PMID: 23023128)
Nat Methods. 2017 Sep 29;14(10):935-936. (PMID: 28960196)
Eur J Obstet Gynecol Reprod Biol. 2011 Mar;155(1):94-8. (PMID: 21130556)
J Immunol. 2008 Feb 15;180(4):2367-75. (PMID: 18250446)
Immunity. 2011 Sep 23;35(3):337-48. (PMID: 21924928)
J Reprod Immunol. 2009 Nov;82(2):148-57. (PMID: 19631389)
Trends Immunol. 2013 Feb;34(2):74-80. (PMID: 23219401)
J Reprod Immunol. 2015 Feb;107:10-9. (PMID: 25453751)
Nat Rev Immunol. 2013 Jan;13(1):23-33. (PMID: 23237963)
Nature. 2018 Dec;564(7735):268-272. (PMID: 30479382)
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6546-E6555. (PMID: 29941600)
Mol Hum Reprod. 2004 May;10(5):347-53. (PMID: 14997000)
Fertil Steril. 2008 Mar;89(3):656-61. (PMID: 17543960)
Toxicol Pathol. 2014;42(2):327-38. (PMID: 23531796)
Am J Reprod Immunol. 2016 Sep;76(3):199-204. (PMID: 27461940)
Clin Cancer Res. 2018 Nov 15;24(22):5685-5696. (PMID: 30065096)
Science. 2016 Apr 8;352(6282):189-96. (PMID: 27124452)
Sci Immunol. 2019 Apr 5;4(34):. (PMID: 30952804)
Am J Reprod Immunol. 2018 Jul;80(1):e12970. (PMID: 29756666)
Cell. 2013 Dec 5;155(6):1282-95. (PMID: 24315098)
Hepatology. 2014 Nov;60(5):1494-507. (PMID: 24756990)
Cell. 2017 Jun 15;169(7):1342-1356.e16. (PMID: 28622514)
J Exp Med. 2006 Oct 30;203(11):2451-60. (PMID: 17015634)
J Immunol. 2019 Mar 15;202(6):1871-1884. (PMID: 30728210)
Biol Reprod. 2010 Apr;82(4):698-705. (PMID: 20018909)
Genome Biol. 2016 Apr 28;17:77. (PMID: 27121950)
J Immunol. 2011 Apr 1;186(7):3918-26. (PMID: 21368230)
Blood. 2012 May 10;119(19):4430-40. (PMID: 22438251)
PLoS One. 2016 Jan 29;11(1):e0148351. (PMID: 26824609)
J Clin Invest. 2019 Apr 8;129(5):2014-2028. (PMID: 30958799)
Sci Rep. 2017 Jun 6;7(1):2884. (PMID: 28588205)
J Immunol. 2010 Apr 1;184(7):3570-81. (PMID: 20181891)
Sci Immunol. 2019 Jan 11;4(31):. (PMID: 30635355)
Science. 2015 Aug 28;349(6251):993-7. (PMID: 26272906)
Nat Immunol. 2011 Apr;12(4):304-11. (PMID: 21378976)
Nat Immunol. 2011 Aug 14;12(9):898-907. (PMID: 21841785)
Cell Rep. 2019 May 28;27(9):2537-2547.e5. (PMID: 31141680)
Immunity. 2009 Jun 19;30(6):899-911. (PMID: 19464196)
Clin Exp Immunol. 2004 May;136(2):373-8. (PMID: 15086404)
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W305-11. (PMID: 19465376)
Mol Syst Biol. 2012;8:624. (PMID: 23169000)
Am J Reprod Immunol. 2010 Jan;63(1):38-45. (PMID: 19912158)
J Hypertens. 2016 Aug;34(8):1570-7. (PMID: 27219485)
فهرسة مساهمة: Keywords: Adaptive immunity; Immunology; Obstetrics/gynecology; Reproductive Biology; T cells
تواريخ الأحداث: Date Created: 20200819 Date Completed: 20210531 Latest Revision: 20210531
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7526557
DOI: 10.1172/jci.insight.137926
PMID: 32809975
قاعدة البيانات: MEDLINE
الوصف
تدمد:2379-3708
DOI:10.1172/jci.insight.137926