Brazil nut prevents oxidative DNA damage in type 2 diabetes patients.

التفاصيل البيبلوغرافية
العنوان:	Brazil nut prevents oxidative DNA damage in type 2 diabetes patients.
المؤلفون:	Macan TP; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil.; Department of Environmental Health, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal., de Amorim TA; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil., Damiani AP; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil., Beretta ÂCDL; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil., Magenis ML; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil., Vilela TC; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil., Teixeira JP; Department of Environmental Health, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal., Andrade VM; Translational Biomedicine Laboratory, Graduate Program of Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, Brazil.
المصدر:	Drug and chemical toxicology [Drug Chem Toxicol] 2022 May; Vol. 45 (3), pp. 1066-1072. Date of Electronic Publication: 2020 Aug 18.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE
أسماء مطبوعة:	Publication: [Philadelphia, PA] : Taylor & Francis Group Original Publication: New York, Dekker.
مواضيع طبية MeSH:	Bertholletia* , Diabetes Mellitus, Type 2* , Selenium*/pharmacology, Humans ; Hydrogen Peroxide/pharmacology ; Oxidative Stress
مستخلص:	The Brazil nut ( Bertholletia excelsa, H.B.K. ) originating from the Amazon region is one of the richest known sources of selenium (Se), a micronutrient that is essential and required for optimal physiological functioning. This mineral presents several health benefits, including improvement of the redox cellular status and maintenance of genomic stability. Knowing that type 2 diabetes mellitus (T2D) is strongly linked to oxidative stress and consequently DNA damage, the aim of this study was to assess the ex vivo antioxidative effects of Se through Brazil nut consumption and its potential in preventing oxidative DNA damage induced by H 2 O 2 . In order to accomplish this, the Comet assay (single-cell gel electrophoresis) was used to measure DNA damage in peripheral blood cells harvested before and after supplementation with Brazil nut. Comet assay was also applied ex vivo to measure the potential of Se to prevent oxidative damage to DNA induced by H 2 O 2 in blood of type 2 diabetes patients collected before and after six months of supplementation with Brazil nut. We found that supplementation with Brazil nuts significantly increased serum Se levels. Furthermore, we observed a significant increase in fasting blood glucose after six months of consuming Brazil nuts; however, no significant effect was observed on the levels of glycated hemoglobin. Finally, we noticed that the cells were more resistant to H 2 O 2 -induced DNA damage after six months of supplementation with Brazil nut. Thus, consumption of Brazil nuts could decrease oxidative DNA damage in T2D patients, probably through the antioxidative effects of Se.
فهرسة مساهمة:	Keywords: Brazil nut; DNA damage; H2O2; antioxidant; comet assay; hyperglycemia; overweight; selenium
المشرفين على المادة:	BBX060AN9V (Hydrogen Peroxide) H6241UJ22B (Selenium)
تواريخ الأحداث:	Date Created: 20200820 Date Completed: 20220408 Latest Revision: 20220408
رمز التحديث:	20221213
DOI:	10.1080/01480545.2020.1808667
PMID:	32811197
قاعدة البيانات:	MEDLINE

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تدمد:	1525-6014
DOI:	10.1080/01480545.2020.1808667