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أعرض في EDS

A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.

التفاصيل البيبلوغرافية
العنوان: A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.
المؤلفون: Schanin J; Allakos, Inc Redwood City, CA, 94065, USA., Gebremeskel S; Allakos, Inc Redwood City, CA, 94065, USA., Korver W; Allakos, Inc Redwood City, CA, 94065, USA., Falahati R; Allakos, Inc Redwood City, CA, 94065, USA., Butuci M; Allakos, Inc Redwood City, CA, 94065, USA., Haw TJ; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia., Nair PM; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia., Liu G; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia., Hansbro NG; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia., Hansbro PM; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW 2305 and The University of Newcastle, Callaghan, NSW, 2208, Australia.; Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, and University of Technology Sydney, School of Life Sciences, Faculty of Science, Ultimo, NSW, 2007, Australia., Evensen E; Basis Bioscience, LLC, Foster City, CA, 94065, USA., Brock EC; Allakos, Inc Redwood City, CA, 94065, USA., Xu A; Allakos, Inc Redwood City, CA, 94065, USA., Wong A; Allakos, Inc Redwood City, CA, 94065, USA., Leung J; Allakos, Inc Redwood City, CA, 94065, USA., Bebbington C; Allakos, Inc Redwood City, CA, 94065, USA., Tomasevic N; Allakos, Inc Redwood City, CA, 94065, USA., Youngblood BA; Allakos, Inc Redwood City, CA, 94065, USA. byoungblood@allakos.com.
المصدر: Mucosal immunology [Mucosal Immunol] 2021 Mar; Vol. 14 (2), pp. 366-376. Date of Electronic Publication: 2020 Aug 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: New York, NY : Nature Pub. Group, c2008-
مواضيع طبية MeSH: Antigens, CD/*metabolism , Antigens, Differentiation, B-Lymphocyte/*metabolism , Lectins/*metabolism , Mast Cells/*immunology , Pneumonia/*immunology , Pulmonary Disease, Chronic Obstructive/*metabolism , Respiratory System/*immunology, Animals ; Antibodies, Monoclonal/metabolism ; Antigens, CD/genetics ; Antigens, Differentiation, B-Lymphocyte/genetics ; Cell Degranulation ; Cigarette Smoking ; Disease Models, Animal ; Gene Expression Profiling ; Immunoglobulin E/metabolism ; Interleukin-33/metabolism ; Lectins/genetics ; Mice ; Mice, Transgenic ; NF-kappa B/metabolism ; Neutrophil Activation ; Signal Transduction
مستخلص: In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory diseases, whereby their activation is likely triggered by non-IgE stimuli (e.g., IL-33). Siglec-8 is an inhibitory receptor expressed on MCs and eosinophils that has been shown to inhibit IgE-mediated MC responses and reduce allergic inflammation upon ligation with a monoclonal antibody (mAb). Herein, we evaluated the effects of an anti-Siglec-8 mAb (anti-S8) in non-allergic disease models of experimental cigarette-smoke-induced chronic obstructive pulmonary disease and bleomycin-induced lung injury in Siglec-8 transgenic mice. Therapeutic treatment with anti-S8 inhibited MC activation and reduced recruitment of immune cells, airway inflammation, and lung fibrosis. Similarly, using a model of MC-dependent, IL-33-induced inflammation, anti-S8 treatment suppressed neutrophil influx, and cytokine production through MC inhibition. Transcriptomic profiling of MCs further demonstrated anti-S8-mediated downregulation of MC signaling pathways induced by IL-33, including TNF signaling via NF-κB. Collectively, these findings demonstrate that ligating Siglec-8 with an antibody reduces non-allergic inflammation and inhibits IgE-independent MC activation, supporting the evaluation of an anti-Siglec-8 mAb as a therapeutic approach in both allergic and non-allergic inflammatory diseases in which MCs play a role.
References: Galli, S. J. & Tsai, M. IgE and mast cells in allergic disease. Nat. Med. 18, 693–704 (2012). (PMID: 225618333597223)
Siebenhaar, F., Redegeld, F. A., Bischoff, S. C., Gibbs, B. F. & Maurer, M. Mast cells as drivers of disease and therapeutic targets. Trends Immunol. 39, 151–162 (2018). (PMID: 29196147)
Hansbro, P. M. et al. Importance of mast cell Prss31/transmembrane tryptase/tryptase-gamma in lung function and experimental chronic obstructive pulmonary disease and colitis. J. Biol. Chem. 289, 18214–18227 (2014). (PMID: 248217294140286)
Beckett, E. L. et al. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J. Allergy Clin. Immunol. 131, 752–762 (2013). (PMID: 233802204060894)
Yu, Y., Blokhuis, B. R., Garssen, J. & Redegeld, F. A. Non-IgE mediated mast cell activation. Eur. J. Pharmacol. 778, 33–43 (2016). (PMID: 26164792)
Enoksson, M. et al. Intraperitoneal influx of neutrophils in response to IL-33 is mast cell-dependent. Blood 121, 530–536 (2013). (PMID: 23093619)
Xia, J. et al. Increased IL-33 expression in chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 308, L619–L627 (2015). (PMID: 25595648)
Lee, J.-U. et al. Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis. BMC Pulm. Med. 17, 39 (2017). (PMID: 282020305312598)
Li, D. et al. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J. Allergy Clin. Immunol. 134, 1422–1432.e11 (2014). (PMID: 249853974258609)
Reber, L. L., Daubeuf, F., Pejler, G., Abrink, M. & Frossard, N. Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J. Immunol. 192, 1847–1854 (2014). (PMID: 24453258)
Youngblood, B. A. et al. AK002, a humanized sialic acid-binding immunoglobulin-like lectin-8 antibody that induces antibody-dependent cell-mediated cytotoxicity against human eosinophils and inhibits mast cell-mediated anaphylaxis in mice. Int. Arch. Allergy Immunol. 180, 91–102 (2019). (PMID: 314016306878738)
Bochner, B. S. ‘Siglec’ting the allergic response for therapeutic targeting. Glycobiology 26, 546–552 (2016). (PMID: 269112854847617)
Yokoi, H. et al. Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. J. Allergy Clin. Immunol. 121, 499–505 (2008). (PMID: 18036650)
O’Sullivan, J. A., Chang, A. T., Youngblood, B. A. & Bochner, B. S. Eosinophil and mast cell Siglecs: from biology to drug target. J. Leukoc. Biol. https://doi.org/10.1002/JLB.2MR0120-352RR (2020).
Youngblood, B. A. et al. Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis. JCI Insight 4, pii: 126219 (2019).
Maurer, M. Efficacy and safety data of AK002, an anti-Siglec-8 monoclonal antibody, in patients with multiple forms of uncontrolled chronic urticaria (CU): results from an open-label phase 2a study. in European Academy of Allergy and Clinical Immunology (EAACI) Annual Meeting LBOA1701 (EAACI, 2019).
Siebenhaar, F. et al. Safety and efficacy data of AK002, an anti-Siglec-8 monoclonal antibody, in patients with indolent systemic mastocytosis (ISM): results from a first-in-human, open-label phase 1 study. in European Academy of Allergy and Clinical Immunology (EAACI) Annual Meeting LBTP1937 (EAACI, 2019).
Tauber, J. et al. AK002, an anti-Siglec-8 monoclonal antibody, in severe allergic conjunctivitis: results from an open-label phase 1b study (KRONOS). in American Academy of Ophthalmology (AAO) Annual Conference P0067 (AAO, 2019).
Yoshizaki, A. et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol. 185, 2502–2515 (2010). (PMID: 206249493733122)
Shen, H., Xu, F., Zhang, G., Wang, S. & Xu, W. CCR3 monoclonal antibody inhibits airway eosinophilic inflammation and mucus overproduction in a mouse model of asthma. Acta Pharmacol. Sin. 27, 1594–1599 (2006). (PMID: 17112414)
Enoksson, M. et al. Mast cells as sensors of cell injury through IL-33 recognition. J. Immunol. 186, 2523–2528 (2011). (PMID: 21239713)
Dwyer, D. F., Barrett, N. A. & Austen, K. F. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat. Immunol. 17, 878–887 (2016). (PMID: 271356045045264)
Chhiba, K. D., Hsu, C.-L., Berdnikovs, S. & Bryce, P. J. Transcriptional heterogeneity of mast cells and basophils upon activation. J. Immunol. 198, 4868–4878 (2017). (PMID: 284769325862545)
Saito, H., Kato, A., Matsumoto, K. & Okayama, Y. Culture of human mast cells from peripheral blood progenitors. Nat. Protoc. 1, 2178–2183 (2006). (PMID: 17487210)
Esteban-Gorgojo, I., Antolin-Amerigo, D., Dominguez-Ortega, J. & Quirce, S. Non-eosinophilic asthma: current perspectives. J. Asthma Allergy 11, 267–281 (2018). (PMID: 304645376211579)
Gabryelska, A., Kuna, P., Antczak, A., Bialasiewicz, P. & Panek, M. IL-33 mediated inflammation in chronic respiratory diseases-understanding the role of the member of IL-1 superfamily. Front. Immunol. 10, 692 (2019). (PMID: 310575336477074)
Overed-Sayer, C., Rapley, L., Mustelin, T. & Clarke, D. L. Are mast cells instrumental for fibrotic diseases? Front. Pharmacol. 4, 174 (2013). (PMID: 24478701)
Huaux, F. et al. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Am. J. Pathol. 167, 1485–1496 (2005). (PMID: 163144641613185)
Huaux, F. et al. Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J. Immunol. 171, 5470–5481 (2003). (PMID: 14607953)
Hao, H., Cohen, D. A., Jennings, C. D., Bryson, J. S. & Kaplan, A. M. Bleomycin-induced pulmonary fibrosis is independent of eosinophils. J. Leukoc. Biol. 68, 515–521 (2000). (PMID: 11037973)
Duan, S. et al. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. J. Clin. Invest 129, 1387–1401 (2019). (PMID: 30645205)
Kraft, S. & Kinet, J.-P. New developments in FcepsilonRI regulation, function and inhibition. Nat. Rev. Immunol. 7, 365–378 (2007). (PMID: 17438574)
Bachelet, I., Munitz, A. & Levi-Schaffer, F. Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J. Allergy Clin. Immunol. 117, 1314–1320 (2006). (PMID: 16750992)
Zellweger, F. et al. A novel bispecific DARPin targeting FcgammaRIIB and FcepsilonRI-bound IgE inhibits allergic responses. Allergy 72, 1174–1183 (2017). (PMID: 27997998)
Boyd, C. R. et al. Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production. J. Immunol. 183, 7703–7709 (2009). (PMID: 199338515580793)
Pillai, S., Netravali, I. A., Cariappa, A. & Mattoo, H. Siglecs and immune regulation. Annu. Rev. Immunol. 30, 357–392 (2012). (PMID: 222247693781015)
Pinto, S. M. et al. A network map of IL-33 signaling pathway. J. Cell Commun. Signal. 12, 615–624 (2018). (PMID: 297059496039344)
Varney, M. E. et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J. Exp. Med. 212, 1967–1985 (2015). (PMID: 264587714612089)
Seya, T., Oshiumi, H., Sasai, M., Akazawa, T. & Matsumoto, M. TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons. Int. J. Biochem. Cell Biol. 37, 524–529 (2005).
Ortiz, M. et al. The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates. Genes Immun. 9, 483–492 (2008). (PMID: 185284032701223)
Majer, O., Liu, B., Kreuk, L. S. M., Krogan, N. & Barton, G. M. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature 575, 366–370 (2019). (PMID: 315462466856441)
Schleimer, R. P. et al. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J. Clin. Invest. 71, 1830–1835 (1983). (PMID: 6134755370388)
Cardet, J. C. & Casale, T. B. New insights into the utility of omalizumab. J. Allergy Clin. Immunol. 143, 923–926.e1 (2019). (PMID: 306900506939862)
Dellon, E. S. et al. Efficacy and safety of AK002 in adult patients with active eosinophilic gastritis and/or eosinophilic gastroenteritis: primary results from a randomized, double-blind placebo-controlled phase 2 trial (ENIGMA Study). in American College of Gastroenterology (ACG) Annual Scientific Meeting 36 (ACG, 2019).
Haw, T. J. et al. A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease. Mucosal Immunol. 9, 859–872 (2016). (PMID: 26555706)
Fricker, M. et al. Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction. JCI insight 3, e94040 (2018).
Horvat, J. C. et al. Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease. Am. J. Respir. Crit. Care Med. 176, 556–564 (2007). (PMID: 17600276)
المشرفين على المادة: 0 (Antibodies, Monoclonal)
0 (Antigens, CD)
0 (Antigens, Differentiation, B-Lymphocyte)
0 (Interleukin-33)
0 (Lectins)
0 (NF-kappa B)
0 (SIGLEC8 protein, human)
37341-29-0 (Immunoglobulin E)
تواريخ الأحداث: Date Created: 20200821 Date Completed: 20211129 Latest Revision: 20230203
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7946634
DOI: 10.1038/s41385-020-00336-9
PMID: 32814824
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-3456
DOI:10.1038/s41385-020-00336-9