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Neuroprotective effect of resveratrol against radiation after surgically induced brain injury by reducing oxidative stress, inflammation, and apoptosis through NRf2/HO-1/NF-κB signaling pathway.

التفاصيل البيبلوغرافية
العنوان: Neuroprotective effect of resveratrol against radiation after surgically induced brain injury by reducing oxidative stress, inflammation, and apoptosis through NRf2/HO-1/NF-κB signaling pathway.
المؤلفون: Zhang Y; Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China., Zhu XB; Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China., Zhao JC; Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China., Gao XF; Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China., Zhang XN; Department of Anesthesiology, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China., Hou K; Department of Neurosurgery, The First Affiliated Hospital of Jilin University, Changchun, Jilin, China.
المصدر: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2020 Dec; Vol. 34 (12), pp. e22600. Date of Electronic Publication: 2020 Aug 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley, c1998-
مواضيع طبية MeSH: Apoptosis/*drug effects , Brain Injuries/*etiology , Neuroprotective Agents/*pharmacology , Oxidative Stress/*drug effects , Resveratrol/*pharmacology , Signal Transduction/*drug effects, Animals ; Brain Injuries/metabolism ; Heme Oxygenase (Decyclizing)/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Rats ; Rats, Wistar
مستخلص: The impact of resveratrol (RSV) on radiation (RAD)-induced brain injury in rats' brains was investigated. A total of 40 male Wistar Albino rats were randomly divided into four groups (control, RAD, RAD + RSV, and RSV groups, with 10 rats in each group). The results revealed a significant decrease in catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, as well as glutathione (GSH) content. Further, a significant elevation in malondialdehyde, nitric oxide, interleukin-1-beta (IL-1β), IL-6, and transforming growth factor-β1 levels were observed. Furthermore, decreased B-cell lymphoma 2 (Bcl-2), increased Bcl-2-associated X, and tumor necrosis factor-α genes expression, decreased nuclear factor erythroid-related factor 2, heme oxygenase-1, and increased nuclear factor-κB protein levels were noticed. Also, an apoptosis marker, caspase-3-positive cells, was seen in the hippocampus. Those effects were observed in the RAD group of rats. The treatment of RSV displayed a significant amendment of the studied parameters in the brain tissues of the RAD group of animals. This effect is interrelated to the ability of RSV to scavenge the free radicals, enhance the activity of the antioxidant enzymes, increase GSH contents, and downregulate the inflammatory responses and apoptosis markers in the brain tissues of RAD animals. In conclusion, this study demonstrated that the potent antioxidant, anti-inflammatory, and antiapoptotic activities of RSV can improve the antioxidant status and suppress the inflammatory responses and apoptosis in the brain tissues of RAD animals.
(© 2020 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: Bcl-2; NF-κB; Nrf2; caspase-3; neurosurgery; radiation; resveratrol
المشرفين على المادة: 0 (NF-E2-Related Factor 2)
0 (NF-kappa B)
0 (Neuroprotective Agents)
0 (Nfe2l2 protein, rat)
EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
EC 1.14.14.18 (Hmox1 protein, rat)
Q369O8926L (Resveratrol)
تواريخ الأحداث: Date Created: 20200821 Date Completed: 20210702 Latest Revision: 20210702
رمز التحديث: 20231215
DOI: 10.1002/jbt.22600
PMID: 32815255
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-0461
DOI:10.1002/jbt.22600