دورية أكاديمية
أعرض في EDS

Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection.

التفاصيل البيبلوغرافية
العنوان: Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection.
المؤلفون: Weber EA; Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY., Singh MV; Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY., Singh VB; Department of Basic and Clinical Sciences Albany College of Pharmacy and Health Sciences Rochester NY., Jackson JW; Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY., Ture SK; Aab Cardiovascular Research Institute University of Rochester Medical Center Rochester NY., Suwunnakorn S; Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY., Morrell CN; Aab Cardiovascular Research Institute University of Rochester Medical Center Rochester NY., Maggirwar SB; Department of Microbiology & Immunology University of Rochester Medical Center Rochester NY.
المصدر: Journal of the American Heart Association [J Am Heart Assoc] 2020 Sep; Vol. 9 (17), pp. e015998. Date of Electronic Publication: 2020 Aug 21.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH: Antiviral Agents/*metabolism , Bone Marrow Stromal Antigen 2/*metabolism , Cell-Derived Microparticles/*genetics , HIV Infections/*metabolism, Adult ; Animals ; Blood Coagulation Factors/metabolism ; Bone Marrow Stromal Antigen 2/pharmacology ; Bone Marrow Stromal Antigen 2/ultrastructure ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cell Membrane/metabolism ; Cell-Derived Microparticles/pathology ; Cell-Derived Microparticles/virology ; Female ; HIV/drug effects ; HIV Infections/blood ; HIV Infections/complications ; HIV Infections/virology ; Humans ; Immunohistochemistry/methods ; Inflammation/metabolism ; Lipopolysaccharide Receptors/metabolism ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Monocytes/metabolism ; Prevalence ; Viral Regulatory and Accessory Proteins/metabolism
مستخلص: Background Microvesicles are cell membrane-derived vesicles that have been shown to augment inflammation. Specifically, monocyte-derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus formation and cardiovascular disease. People living with HIV experience higher prevalence of cardiovascular disease and also exhibit increased levels of plasma microvesicles. The process of microvesicle release has striking similarity to budding of enveloped viruses. The surface protein tetherin inhibits viral budding by physically tethering budding virus particles to cells. Hence, we investigated the role of tetherin in regulating the release of MDMVs during HIV infection. Methods and Results The plasma of aviremic HIV-infected individuals had increased levels of tissue factor + MDMVs, as measured by flow cytometry, and correlated to reduced tetherin expression on monocytes. Superresolution confocal and electron microscopy showed that tetherin localized at the site of budding MDMVs. Mechanistic studies revealed that the exposure of monocytes to HIV-encoded Tat triggered tetherin loss and subsequent rise in MDMV production. Overexpression of tetherin in monocytes led to morphologic changes in the pseudopodia directly underneath the MDMVs. Further, tetherin knockout mice demonstrated a higher number of circulating MDMVs and less time to bleeding cessation. Conclusions Our studies define a novel regulatory mechanism of MDMV release through tetherin and explore its contribution to the procoagulatory state that is frequently observed in people with HIV. Such insights could lead to improved therapies for individuals infected with HIV and also for those with cardiovascular disease.
References: JAMA Intern Med. 2013 Apr 22;173(8):614-22. (PMID: 23459863)
Blood. 2004 Nov 15;104(10):3190-7. (PMID: 15280200)
Nature. 2008 Jan 24;451(7177):425-30. (PMID: 18200009)
Cell. 2009 Oct 30;139(3):499-511. (PMID: 19879838)
Biochemistry (Mosc). 2016 Feb;81(2):114-21. (PMID: 27260391)
Sci Rep. 2016 Oct 27;6:35928. (PMID: 27786276)
Traffic. 2003 Oct;4(10):694-709. (PMID: 12956872)
Infect Disord Drug Targets. 2012 Feb;12(1):81-6. (PMID: 22280310)
J Virol. 2019 Dec 12;94(1):. (PMID: 31597764)
Nat Med. 2000 Jul;6(7):769-75. (PMID: 10888925)
AIDS Res Hum Retroviruses. 2016 Feb;32(2):144-7. (PMID: 26366931)
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11466-71. (PMID: 11027346)
Retrovirology. 2010 Dec 22;7:114. (PMID: 21176220)
PLoS Biol. 2019 Jul 18;17(7):e3000363. (PMID: 31318874)
Nat Rev Neurol. 2016 Apr;12(4):234-48. (PMID: 26965674)
Cell Host Microbe. 2012 Nov 15;12(5):633-44. (PMID: 23159053)
HIV Med. 2015 Oct;16(9):553-62. (PMID: 25944318)
J Clin Invest. 1997 May 1;99(9):2118-27. (PMID: 9151784)
J Infect Dis. 2011 Mar 15;203(6):780-90. (PMID: 21252259)
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51. (PMID: 22315426)
J Virol. 2016 Jun 10;90(13):5886-5898. (PMID: 27053552)
PLoS One. 2012;7(12):e51793. (PMID: 23251626)
Cancer Microenviron. 2010 Jul 13;4(1):93-103. (PMID: 21505564)
J Hepatol. 2012 Nov;57(5):1144-6. (PMID: 22878465)
Curr Biol. 2009 Dec 1;19(22):1875-85. (PMID: 19896381)
Elife. 2016 Sep 22;5:. (PMID: 27657169)
Blood. 2000 Jul 1;96(1):188-94. (PMID: 10891450)
PLoS One. 2014 Mar 19;9(3):e91597. (PMID: 24646764)
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13588-93. (PMID: 23898208)
PLoS One. 2016 Jun 29;11(6):e0158169. (PMID: 27355513)
Sci Rep. 2019 Feb 26;9(1):2781. (PMID: 30808933)
Clin Gastroenterol Hepatol. 2010 Dec;8(12):1002-12. (PMID: 20851211)
J Gen Virol. 2002 May;83(Pt 5):1173-1181. (PMID: 11961273)
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2886-91. (PMID: 19179289)
J Leukoc Biol. 2005 Dec;78(6):1318-26. (PMID: 16204641)
J Biol Chem. 2012 Apr 27;287(18):14837-50. (PMID: 22383521)
J Thromb Haemost. 2012 Dec;10(12):2563-72. (PMID: 23039852)
Blood. 2014 Oct 2;124(14):2173-83. (PMID: 25082876)
Blood. 2005 Sep 1;106(5):1604-11. (PMID: 15741221)
Coron Artery Dis. 2016 Aug;27(5):365-75. (PMID: 27058313)
Sci Rep. 2018 Jul 3;8(1):9987. (PMID: 29968812)
FEBS J. 2015 Feb;282(3):595-610. (PMID: 25472883)
Front Immunol. 2015 Jan 30;5:676. (PMID: 25688240)
J Leukoc Biol. 2017 Oct;102(4):953-964. (PMID: 28663244)
Oncotarget. 2017 Apr 18;8(16):27569-27581. (PMID: 28187438)
Biochem Res Int. 2011;2011:245090. (PMID: 22191032)
J Immunol. 1994 Oct 1;153(7):3245-55. (PMID: 7522256)
Eukaryot Cell. 2014 Dec;13(12):1484-93. (PMID: 24906412)
J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):506-12. (PMID: 12869840)
J Vet Intern Med. 2013 Sep-Oct;27(5):1020-33. (PMID: 23815149)
Clin Infect Dis. 2011 Dec;53(11):1120-6. (PMID: 21998278)
J Virol. 2013 Dec;87(24):13124-33. (PMID: 24067975)
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):15-26. (PMID: 21160064)
AIDS. 2013 Jun 1;27(9):1387-95. (PMID: 23435298)
J Infect Dis. 2016 Oct 15;214(8):1198-204. (PMID: 27354366)
Langmuir. 2018 Aug 14;34(32):9387-9393. (PMID: 29542322)
PLoS Pathog. 2013;9(7):e1003483. (PMID: 23874200)
J Virol. 2009 Oct;83(19):9672-81. (PMID: 19605472)
J Cell Sci. 2013 Apr 1;126(Pt 7):1553-64. (PMID: 23378022)
Thromb J. 2003 Oct 11;1(1):6. (PMID: 14613528)
J Am Heart Assoc. 2020 Sep;9(17):e015998. (PMID: 32819189)
Am J Physiol Regul Integr Comp Physiol. 2014 Jun 1;306(11):R814-22. (PMID: 24694382)
J Leukoc Biol. 2015 Feb;97(2):237-45. (PMID: 25473096)
AIDS. 2014 Apr 24;28(7):969-77. (PMID: 24691204)
Mol Ther. 2003 Jan;7(1):122-8. (PMID: 12573625)
PLoS Pathog. 2011 Nov;7(11):e1002332. (PMID: 22072961)
Blood. 2010 Jan 14;115(2):161-7. (PMID: 19828697)
J Thromb Haemost. 2017 Aug;15(8):1655-1667. (PMID: 28561434)
BMC Cell Biol. 2013 Apr 22;14:23. (PMID: 23607880)
J Clin Invest. 1991 Jan;87(1):27-30. (PMID: 1985101)
PLoS One. 2012;7(12):e51033. (PMID: 23236425)
Kidney Int. 2006 Apr;69(8):1416-23. (PMID: 16531979)
PLoS One. 2014 Mar 04;9(3):e90541. (PMID: 24594990)
Leukemia. 2006 May;20(5):847-56. (PMID: 16453000)
J Am Coll Cardiol. 2013 Oct 15;62(16):1436-41. (PMID: 23707318)
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18097-101. (PMID: 22025715)
Oncogene. 2012 Nov 8;31(45):4740-9. (PMID: 22266864)
Cell Signal. 2013 Dec;25(12):2752-61. (PMID: 24036213)
Sci Rep. 2016 May 31;6:26876. (PMID: 27241024)
Biochem Biophys Res Commun. 2013 Aug 9;437(4):591-6. (PMID: 23850678)
Blood. 2011 Aug 25;118(8):2366-74. (PMID: 21700772)
Anesth Analg. 2009 May;108(5):1447-52. (PMID: 19372318)
Analyst. 2015 Oct 7;140(19):6631-42. (PMID: 26332016)
J Cell Biol. 2009 Mar 9;184(5):721-36. (PMID: 19273615)
J Am Heart Assoc. 2019 Feb 19;8(4):e011134. (PMID: 30779672)
Circulation. 2002 Nov 5;106(19):2442-7. (PMID: 12417540)
J Acquir Immune Defic Syndr. 2012 Apr 1;59(4):340-6. (PMID: 22156911)
J Neurovirol. 2015 Apr;21(2):186-98. (PMID: 25636783)
Clin Infect Dis. 2014 Dec 15;59(12):1787-97. (PMID: 25182245)
PLoS Pathog. 2009 Dec;5(12):e1000700. (PMID: 20019814)
J Virol. 2000 Nov;74(22):10551-62. (PMID: 11044099)
Nat Protoc. 2009;4(4):495-505. (PMID: 19300443)
J Neurovirol. 2015 Aug;21(4):439-48. (PMID: 25776526)
معلومات مُعتمدة: R01 NS066801 United States NS NINDS NIH HHS; R01 HL128155 United States HL NHLBI NIH HHS; T32 AI049815 United States AI NIAID NIH HHS; R01 HL123346 United States HL NHLBI NIH HHS; P30 AI078498 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: human immunodeficiency virus; immunogold; microvesicles; monocytes; scanning electron microscopy; tetherin; tissue factor
المشرفين على المادة: 0 (Antiviral Agents)
0 (Blood Coagulation Factors)
0 (Bone Marrow Stromal Antigen 2)
0 (Lipopolysaccharide Receptors)
0 (Viral Regulatory and Accessory Proteins)
0 (leukocyte procoagulant activity)
تواريخ الأحداث: Date Created: 20200822 Date Completed: 20210309 Latest Revision: 20240430
رمز التحديث: 20240430
مُعرف محوري في PubMed: PMC7660781
DOI: 10.1161/JAHA.120.015998
PMID: 32819189
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-9980
DOI:10.1161/JAHA.120.015998