دورية أكاديمية
The Effects of Kefir on Kidney Tissues and Functions in Diabetic Rats.
| العنوان: | The Effects of Kefir on Kidney Tissues and Functions in Diabetic Rats. |
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| المؤلفون: | Kahraman M; Istanbul School of Medicine, Department of Physiology, Istanbul University, Istanbul, Turkey. mkahraman17@gmail.com., Ertekin YH; School of Medicine, Department of Family Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey., Satman İ; Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul University, Istanbul, Turkey. |
| المصدر: | Probiotics and antimicrobial proteins [Probiotics Antimicrob Proteins] 2021 Apr; Vol. 13 (2), pp. 375-382. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101484100 Publication Model: Print Cited Medium: Internet ISSN: 1867-1314 (Electronic) Linking ISSN: 18671306 NLM ISO Abbreviation: Probiotics Antimicrob Proteins Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY. : Springer |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental*/complications , Diabetes Mellitus, Experimental*/therapy , Kefir*, Kidney/*physiopathology , Kidney Diseases/*therapy, Animals ; Blood Glucose ; Creatinine ; Kidney Diseases/etiology ; Rats |
| مستخلص: | This study was designed to determine the protective effect of kefir on the oxidative damage, as well as histological and biochemical changes that occur in the kidney tissues of experimental diabetic rats. Forty rats were allocated into four groups as "healthy saline" (SF), "healthy kefir" (KF), and the same groups with experimentally induced diabetes (DSF and DKF). Diabetes was induced by administering 65 mg/kg single-dose streptozotocin. Oral kefir was given 10 ml/kg/day for 35 days to the rats in the groups KF and DKF. The same amount of saline was given to the groups SF and DSF. On the 36th day of the study, blood glucose, urea, and creatinine were measured besides glucose, creatinine, microalbuminuria, and sodium in the urine. Additionally, histological examination was performed on the kidney tissues. Blood glucose, creatinine, and urea levels were significantly lower in the DKF group compared with those of the DSF group (p < 0.001). Also, the creatinine level was significantly decreased (p < 0.001), and microalbuminuria was increased (p < 0.001) in the DKF group compared with that of the DSF group. Histologically, intermittent expansion in the renal glomeruli, reduction of cast formation in the tubules, and improvement in the renal epithelial tissues of the DKF group were observed. Kefir decreased the damage caused by diabetes. These results indicate that kefir supplementation may contribute to better control of oxidative stress, which is related to the improvement of renal functions, suggesting its use to slow down the progression of diabetic nephropathy. |
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| معلومات مُعتمدة: | 2014-TYL-183 Çanakkale Onsekiz Mart Üniversitesi |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; Diabetic nephropathy; In vivo experiment; Kefir; Rats; Reduction of oxidative stress; Streptozocin |
| المشرفين على المادة: | 0 (Blood Glucose) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20200822 Date Completed: 20220103 Latest Revision: 20220103 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s12602-020-09698-9 |
| PMID: | 32820468 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1867-1314 |
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| DOI: | 10.1007/s12602-020-09698-9 |