دورية أكاديمية
Simpson Grade Revisited - Intraoperative Estimation of the Extent of Resection in Meningiomas Versus Postoperative Somatostatin Receptor Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging.
| العنوان: | Simpson Grade Revisited - Intraoperative Estimation of the Extent of Resection in Meningiomas Versus Postoperative Somatostatin Receptor Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging. |
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| المؤلفون: | Ueberschaer M; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Vettermann FJ; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Forbrig R; Institute of Neuroradiology, University Hospital, Ludwig-Maximilians-University, Munich, Germany., Unterrainer M; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Siller S; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Biczok AM; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Thorsteinsdottir J; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Cyran CC; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Bartenstein P; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Tonn JC; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Albert NL; Department of Nuclear Medicine, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany., Schichor C; Department of Neurosurgery, University Hospital, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), partner site Munich, Germany. |
| المصدر: | Neurosurgery [Neurosurgery] 2020 Dec 15; Vol. 88 (1), pp. 140-146. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 7802914 Publication Model: Print Cited Medium: Internet ISSN: 1524-4040 (Electronic) Linking ISSN: 0148396X NLM ISO Abbreviation: Neurosurgery Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [Philadelphia] : Lippincott Williams & Wilkins, Inc. Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Meningeal Neoplasms/*diagnostic imaging , Meningeal Neoplasms/*surgery , Meningioma/*diagnostic imaging , Meningioma/*surgery , Neoplasm, Residual/*diagnostic imaging, Adult ; Aged ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neurosurgical Procedures ; Positron Emission Tomography Computed Tomography/methods ; Receptors, Somatostatin ; Retrospective Studies |
| مستخلص: | Background: Surgeon's intraoperative estimation of meningioma extent of resection (Simpson Grade, SG) is widely used as a prognostic factor for recurrence. However, the validity of SG is still a matter of debate. In preoperative imaging, 68Ga-DOTATATE/PET-CT has been shown to detect meningioma tissue even more sensitively than magnetic resonance imaging (MRI). Objective: To evaluate the Simpson grading within the framework of modern postoperative imaging techniques (MRI; PET-CT). Methods: At first, patients with WHO grade I meningioma, surgical resection, and postoperative 68Ga-DOTATATE/PET-CT within 6 mo after surgery were retrospectively analyzed. Second, an analogous prospective cohort of patients with WHO grade I meningioma was investigated by comparing SG after meningioma removal with postoperative MRI and 68Ga-DOTATATE/PET-CT within 6 mo after surgery. Results: A total of 37 patients were retrospectively analyzed. In total, 5/8 patients with SG-I and II resections showed tumor remnants according to postoperative PET-CT (SG 62.5% false negative). In the prospective cohort of 52 tumors, PET-CT displayed tracer uptake in 15/37 SG-I or II resections indicating unexpected tumor remnants (SG 40.5% false negative). MRI was false negative in 7 of these 15 cases (MRI 18.9% false negative) (P = .037). Discordant results according to PET-CT were more often found in convexity (40%) and falcine (46.7%) meningiomas than in skull base meningiomas (18.2%). Conclusion: Intraoperative Simpson grading is at risk to underestimate tumor remnants, predominantly in grade I and II resections. Postoperative PET-CT improves detection rates compared to MRI. Prognostic impact of postoperative meningioma remnants according to PET-CT needs to be investigated prospectively. (Copyright © 2020 by the Congress of Neurological Surgeons.) |
| فهرسة مساهمة: | Keywords: Extent of resection; MRI; Meningioma; PET; Simpson grade |
| المشرفين على المادة: | 0 (Receptors, Somatostatin) |
| تواريخ الأحداث: | Date Created: 20200823 Date Completed: 20210315 Latest Revision: 20210315 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/neuros/nyaa333 |
| PMID: | 32827256 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4040 |
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| DOI: | 10.1093/neuros/nyaa333 |