دورية أكاديمية
أعرض في EDS

Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro.

التفاصيل البيبلوغرافية
العنوان: Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro.
المؤلفون: Minori K; Department of Animal Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, 13083-862., Campinas, SP, Brazil., Rosa LB; Department of Animal Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, 13083-862., Campinas, SP, Brazil., Bonsignore R; Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstraße 4, 85748, Garching b. München, Germany., Casini A; Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstraße 4, 85748, Garching b. München, Germany., Miguel DC; Department of Animal Biology, Biology Institute, University of Campinas (UNICAMP), Rua Monteiro Lobato, 255, 13083-862., Campinas, SP, Brazil.
المصدر: ChemMedChem [ChemMedChem] 2020 Nov 18; Vol. 15 (22), pp. 2146-2150. Date of Electronic Publication: 2020 Sep 28.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Weinheim, Germany : Wiley-VCH, c2006-
مواضيع طبية MeSH: Antiprotozoal Agents/*pharmacology , Leishmania/*drug effects , Organogold Compounds/*pharmacology, Animals ; Antiprotozoal Agents/chemistry ; Cells, Cultured ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Organogold Compounds/chemistry ; Parasitic Sensitivity Tests
مستخلص: A series of mononuclear coordination or organometallic Au I /Au III complexes (1-9) have been comparatively studied in vitro for their antileishmanial activity against promastigotes and amastigotes, the clinically relevant parasite form, of Leishmania amazonensis and Leishmania braziliensis. One of the cationic Au I bis-N-heterocyclic carbenes (3) has low EC 50 values (ca. 4 μM) in promastigotes cells and no toxicity in host macrophages. Together with two other Au III complexes (6 and 7), the compound is also extremely effective in intracellular amastigotes from L. amazonensis. Initial mechanistic studies include an evaluation of the gold complexes' effect on L. amazonensis' plasma membrane integrity.
(© 2020 The Authors. Published by Wiley-VCH GmbH.)
References: Eur J Med Chem. 2017 Feb 15;127:727-739. (PMID: 27823888)
Chem Commun (Camb). 2017 Mar 30;53(27):3830-3833. (PMID: 28304043)
Biometals. 2017 Apr;30(2):313-320. (PMID: 28283781)
Chem Commun (Camb). 2018 Jan 16;54(6):611-614. (PMID: 29292454)
Arch Pharm (Weinheim). 2020 May;353(5):e1900363. (PMID: 32149417)
PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006052. (PMID: 29240765)
Dalton Trans. 2015 Jul 14;44(26):11911-8. (PMID: 26060937)
ChemMedChem. 2020 Nov 18;15(22):2146-2150. (PMID: 32830445)
Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):430-439. (PMID: 30293058)
J Med Chem. 2006 Nov 16;49(23):6811-8. (PMID: 17154511)
Dalton Trans. 2014 Mar 21;43(11):4209-19. (PMID: 24225667)
Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14524-14528. (PMID: 29972613)
Chemistry. 2017 Feb 3;23(8):1869-1880. (PMID: 27865002)
Eur J Med Chem. 2018 Jan 1;143:1635-1643. (PMID: 29133045)
Chem Soc Rev. 2019 Jan 21;48(2):447-462. (PMID: 30474097)
Inorg Chem. 2014 Feb 17;53(4):2296-303. (PMID: 24499428)
Inorg Chem. 2012 Mar 5;51(5):3161-71. (PMID: 22339487)
Chem Rev. 2013 May 8;113(5):3450-92. (PMID: 23425067)
Eur J Med Chem. 2015 Apr 13;94:22-9. (PMID: 25747497)
Chemistry. 2019 Jun 7;25(32):7628-7634. (PMID: 30990916)
PLoS One. 2012;7(5):e35671. (PMID: 22693548)
BMC Genomics. 2009 Aug 06;10:362. (PMID: 19660104)
Mol Biochem Parasitol. 1986 Jun;19(3):195-200. (PMID: 3736592)
Med Res Rev. 2010 May;30(3):550-80. (PMID: 19634148)
Chembiochem. 2020 Nov 2;21(21):3071-3076. (PMID: 32511840)
Amino Acids. 2012 Feb;42(2-3):803-11. (PMID: 21833767)
Trop Med Int Health. 2001 Nov;6(11):849-54. (PMID: 11703838)
Trop Med Int Health. 2010 Jan;15(1):68-76. (PMID: 19874570)
Chem Rev. 2019 Jan 23;119(2):730-796. (PMID: 30507157)
J Inorg Biochem. 2007 Jan;101(1):111-6. (PMID: 17055060)
Inorg Chem. 2019 Feb 4;58(3):2140-2148. (PMID: 30645101)
Comp Biochem Physiol C Toxicol Pharmacol. 2019 Dec;226:108612. (PMID: 31454702)
J Immunol Methods. 1990 Dec 5;134(2):201-5. (PMID: 2254666)
ACS Infect Dis. 2020 May 8;6(5):1121-1139. (PMID: 32283915)
FEMS Microbiol Lett. 2016 Jul;363(14):. (PMID: 27279627)
Angew Chem Int Ed Engl. 2020 Sep 14;59(38):16795-16800. (PMID: 32529715)
J Inorg Biochem. 2020 Jan;202:110844. (PMID: 31739113)
Chem Sci. 2020 Feb 12;11(10):2627-2639. (PMID: 32206266)
J Inorg Biochem. 2011 May;105(5):754-62. (PMID: 21481817)
FEBS Lett. 2008 Mar 19;582(6):844-7. (PMID: 18294965)
فهرسة مساهمة: Keywords: amastigotes; antiprotozoal agents; gold compounds; leishmaniasis; promastigotes
المشرفين على المادة: 0 (Antiprotozoal Agents)
0 (Organogold Compounds)
تواريخ الأحداث: Date Created: 20200825 Date Completed: 20210914 Latest Revision: 20231110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7756297
DOI: 10.1002/cmdc.202000536
PMID: 32830445
قاعدة البيانات: MEDLINE
الوصف
تدمد:1860-7187
DOI:10.1002/cmdc.202000536