دورية أكاديمية
أعرض في EDS

A Higher Incidence of Isolated Biliary Atresia in Rural Areas: Results From an Epidemiological Study in The Netherlands.

التفاصيل البيبلوغرافية
العنوان: A Higher Incidence of Isolated Biliary Atresia in Rural Areas: Results From an Epidemiological Study in The Netherlands.
المؤلفون: Nomden M; Section of Paediatric Surgery, Department of Surgery, University Medical Centre Groningen., van Wessel DBE; Section of Paediatric Surgery, Department of Surgery, University Medical Centre Groningen., Ioannou S; Department of Epidemiology, University Medical Centre Groningen., Verkade HJ; Section of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen., de Kleine RH; Section of Hepato-pancreatic-biliary Surgery and Liver Transplantation, Department of Surgery, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Alizadeh BZ; Department of Epidemiology, University Medical Centre Groningen., Bruggink JLM; Section of Paediatric Surgery, Department of Surgery, University Medical Centre Groningen., Hulscher JBF; Section of Paediatric Surgery, Department of Surgery, University Medical Centre Groningen.
المصدر: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2021 Feb 01; Vol. 72 (2), pp. 202-209.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [Hoboken, New Jersey] : Wiley
Original Publication: [New York, N.Y.] : Raven Press, [c1982-
مواضيع طبية MeSH: Biliary Atresia*/epidemiology , Biliary Atresia*/etiology, Epidemiologic Studies ; Humans ; Incidence ; Netherlands/epidemiology ; Rural Population
مستخلص: Objectives: Environmental factors may be involved in the pathogenesis of biliary atresia (BA). This epidemiological study aimed to analyze the relationships between the incidence of BA, the incidence of confirmed viral or bacterial infections and population density, and geographical and temporal clustering of BA in the Netherlands.
Study Design: Correlations between the monthly incidence of BA and the number of confirmed infections were assessed. BA incidence per province was calculated and compared to the province with highest population density. Birthplaces were classified as rural or urban. Temporal clustering of month of birth and month of conception were analyzed. We performed analyses for isolated BA (IBA) and syndromic BA (SBA) separately. Chi2, logistic regression, and Walter and Elwood test were used.
Results: A total of 262 IBA and 49 SBA patients, born between 1987 and 2018, were included. IBA incidence correlated to the number of confirmed infections of, for example, Chlamydia trachomatis (R = 0.14; P = 0.02) and adenovirus (R = 0.22; P = 0.005). We observed a higher incidence of IBA (0.75/10,000; odds ratio [OR] = 1.86; P = 0.04) and SBA (0.27/10,000; OR = 6.91; P = 0.001) in Groningen and a higher incidence of SBA in Gelderland (0.13/10,000; OR = 3.35; P = 0.03). IBA incidence was 68% higher in rural (0.67/10,000) versus urban areas (0.40/10,000) (P = 0.02). The estimated month of conception of patients with SBA clustered in November (85% increase compared to average SBA incidence [0.09/10,000; P = 0.04]).
Conclusions: IBA incidence correlated weakly with national confirmed infections. IBA and SBA incidence varied geographically in the Netherlands. IBA incidence was higher in rural than in urban areas, which may be explained decreased exposure to pathogens. Our results provide support for a role of environmental factors in the pathogenesis of IBA.
Competing Interests: The authors report no conflicts of interest.
(Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
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تواريخ الأحداث: Date Created: 20200825 Date Completed: 20210618 Latest Revision: 20230822
رمز التحديث: 20230822
DOI: 10.1097/MPG.0000000000002916
PMID: 32833894
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-4801
DOI:10.1097/MPG.0000000000002916