دورية أكاديمية
أعرض في EDS

Cell polarity (the 'four lines') distinguishes gastric dysplasia from epithelial changes in reactive gastropathy.

التفاصيل البيبلوغرافية
العنوان: Cell polarity (the 'four lines') distinguishes gastric dysplasia from epithelial changes in reactive gastropathy.
المؤلفون: Waters KM; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Salimian KJ; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Assarzadegan N; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Hutchings D; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Makhoul EP; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Windon AL; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Wong MT; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Voltaggio L; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA., Montgomery EA; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, USA.
المصدر: Histopathology [Histopathology] 2021 Feb; Vol. 78 (3), pp. 453-458. Date of Electronic Publication: 2020 Oct 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Blackwell Scientific Publications.
مواضيع طبية MeSH: Cell Polarity*, Gastric Mucosa/*pathology, Adult ; Barrett Esophagus/diagnosis ; Barrett Esophagus/pathology ; Biopsy ; Female ; Gastritis/diagnosis ; Gastritis/pathology ; Humans ; Male ; Middle Aged ; Precancerous Conditions/diagnosis ; Precancerous Conditions/pathology
مستخلص: Aims: Gastric dysplasia is a risk factor for synchronous and subsequent gastric carcinoma. Distinguishing gastric dysplasia from reactive changes is subject to interobserver disagreement and is a frequent reason for expert consultation. We previously used assessment of surface cell polarity (the 'four lines') as a key feature to decrease equivocal diagnoses in Barrett oesophagus. In the current study, we examined for the presence or absence of the four lines in gastric dysplasia and reactive gastropathy.
Materials and Methods: The study includes all (n = 91) in-house biopsies with at least gastric dysplasia from the surgical pathology archives of two academic institutions during a 5-year period from 2008 to 2012. A reactive gastropathy group (n = 60) was created for comparison.
Results: The dysplasia/neoplasia group was comprised of 14 biopsies of gastric foveolar-type dysplasia, 59 of intestinal-type dysplasia, 14 with dysplasia in fundic gland polyps, three pyloric gland adenomas and one oxyntic gland adenoma. Loss of surface cell polarity was seen in all 88 dysplasia cases with evaluable surface epithelium. All 57 reactive gastropathy cases with evaluable surface epithelium showed intact surface cell polarity except in focal areas directly adjacent to erosions in 17 cases, where the thin wisp of residual surface mucin could not be appreciated on haematoxylin and eosin.
Conclusion: Surface cell polarity (the four lines) was lost in all gastric dysplasia biopsies with evaluable surface epithelium and maintained in all biopsies of reactive gastropathy. Caution should be taken in using this feature adjacent to erosions in reactive gastropathy.
(© 2020 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: T32 CA193145 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: gastric dysplasia; precursor; reactive gastropathy
تواريخ الأحداث: Date Created: 20200826 Date Completed: 20211102 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9281539
DOI: 10.1111/his.14242
PMID: 32841414
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2559
DOI:10.1111/his.14242