دورية أكاديمية
Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.
العنوان: | Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors. |
---|---|
المؤلفون: | Conley AC; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Karayanidis F; Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science, University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Jolly TAD; Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science, University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Yang MH; Department of Psychology, National Cheng Kung University, Tainan, Taiwan.; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.; Department and Institute of Public health, National Cheng Kung University, Tainan, Taiwan., Hsieh S; Department of Psychology, National Cheng Kung University, Tainan, Taiwan.; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.; Department and Institute of Public health, National Cheng Kung University, Tainan, Taiwan. |
المصدر: | Frontiers in aging neuroscience [Front Aging Neurosci] 2020 Aug 07; Vol. 12, pp. 245. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | Aging is associated with an increased prevalence of vascular health conditions that are linked to a disruption in the cerebral vasculature and white matter microstructural organization. In people with cardiovascular risk factors, increased cerebral arterial pulsatility is associated with poorer white matter microstructural organization and cognitive functioning. This study examines the relationship among arterial pulsatility, white matter microstructural organization, and cognitive ability in a healthy adult lifespan sample. One hundred and eighty-nine adults were divided into a younger adult (<50 years, n = 97) and older adult (>50 years, n = 92). The latter were further subdivided into two subgroups with (CV+, n = 25) and without (CV-, n = 67) cardiovascular risk factors. Arterial pulsatility was measured using cardiac-gated phase-contrast flow quantification sequence and three indexes of whole-brain white matter microstructural organization [i.e., fractional anisotropy (FA), radial diffusivity (RaD), mean diffusivity (MD)] were derived from diffusion-weighted imaging (DWI). Cognitive ability was assessed using global cognitive functioning (MoCA) and a measure of working memory [sensitivity ( d' ) from a 2-back task]. Neither the whole group analysis nor the younger adult group showed an association between measures of arterial pulsatility, global white matter microstructural organization, and cognition. In older adults, higher MD and RaD were associated with increased arterial pulsatility and poorer working memory performance. The indirect pathway from arterial pulsatility to working memory performance via both MD and RaD measures was significant in this group. Interestingly, a comparison of CV+ and CV- subgroups showed that this mediating relationship was only evident in older adults with at least one CV risk factor. These findings are consistent with cardiovascular risk factors as underlying arterial, white matter, and cognitive decline in cognitively normal older adults. (Copyright © 2020 Conley, Karayanidis, Jolly, Yang and Hsieh.) |
References: | Drugs Aging. 2011 Oct 1;28(10):779-95. (PMID: 21970306) Neuroimage. 2016 May 1;131:91-101. (PMID: 26439513) Neurobiol Aging. 2019 Dec;84:200-207. (PMID: 31500910) J Am Geriatr Soc. 2005 Apr;53(4):695-9. (PMID: 15817019) J Int Neuropsychol Soc. 2014 Mar;20(3):262-7. (PMID: 24528516) Neuroradiology. 2002 Sep;44(9):740-8. (PMID: 12221445) Neuropsychology. 2011 Mar;25(2):237-48. (PMID: 21381828) AJNR Am J Neuroradiol. 2002 Sep;23(8):1327-33. (PMID: 12223373) Neuroimage. 2019 Aug 1;196:16-31. (PMID: 30954708) JAMA. 2019 Feb 12;321(6):553-561. (PMID: 30688979) Brain Struct Funct. 2016 May;221(4):2135-46. (PMID: 25833685) NMR Biomed. 2002 Nov-Dec;15(7-8):570-7. (PMID: 12489103) Hum Brain Mapp. 2017 Mar;38(3):1588-1603. (PMID: 27879030) Circ Cardiovasc Qual Outcomes. 2013 Jul;6(4):451-60. (PMID: 23838109) Hum Brain Mapp. 2010 Mar;31(3):378-90. (PMID: 19662658) Ageing Res Rev. 2017 Mar;34:15-29. (PMID: 27693240) J Neurosci. 2015 Jul 8;35(27):10015-24. (PMID: 26157001) Brain. 1991 Apr;114 ( Pt 2):761-74. (PMID: 2043948) Med Hypotheses. 2004;62(2):182-7. (PMID: 14962623) Radiology. 2000 Sep;216(3):672-82. (PMID: 10966694) Psychophysiology. 2014 Nov;51(11):1072-88. (PMID: 25100639) Neuroradiology. 2008 Jun;50(6):491-7. (PMID: 18379767) Front Hum Neurosci. 2013 Nov 18;7:782. (PMID: 24302906) BMC Med Imaging. 2010 Jan 11;10:1. (PMID: 20064248) Alzheimers Dement (Amst). 2018 Mar 05;10:278-284. (PMID: 29644327) Psychophysiology. 2016 Feb;53(2):258-67. (PMID: 26511789) Neuroimage. 2003 Nov;20(3):1714-22. (PMID: 14642481) Neuroimage. 2011 Mar 15;55(2):468-78. (PMID: 21167947) Neurology. 1994 Jul;44(7):1246-52. (PMID: 8035924) Front Aging Neurosci. 2013 Nov 12;5:75. (PMID: 24282403) Am J Prev Med. 2005 Oct;29(3):185-93. (PMID: 16168867) Psychol Sci. 2007 Jul;18(7):614-21. (PMID: 17614870) Brain Res. 2009 Nov 10;1297:41-56. (PMID: 19712671) Nat Rev Endocrinol. 2018 Oct;14(10):591-604. (PMID: 30022099) Proc Natl Acad Sci U S A. 2008 May 13;105(19):6829-33. (PMID: 18443283) Hum Brain Mapp. 2017 Jun;38(6):3249-3261. (PMID: 28370780) Cortex. 2015 May;66:115-33. (PMID: 25684445) Br J Psychiatry. 2020 Jan;216(1):16-28. (PMID: 31368428) Brain Behav Immun. 2004 May;18(3):214-20. (PMID: 15116743) Brain. 2011 Nov;134(Pt 11):3398-407. (PMID: 22075523) PLoS One. 2014 Sep 17;9(9):e107413. (PMID: 25229455) Neurobiol Aging. 2019 Feb;74:46-55. (PMID: 30415127) Med Image Anal. 2001 Jun;5(2):143-56. (PMID: 11516708) Hum Brain Mapp. 2002 Nov;17(3):143-55. (PMID: 12391568) Stroke. 2012 Oct;43(10):2631-6. (PMID: 22923446) J Hum Hypertens. 2014 Jul;28(7):444-9. (PMID: 24384629) Am J Hypertens. 2018 May 7;31(6):631-642. (PMID: 29481592) Neuroimage. 2011 Jun 1;56(3):1145-53. (PMID: 21385618) Neuroimage. 2006 Jul 15;31(4):1487-505. (PMID: 16624579) Neuroimage. 2012 Aug 15;62(2):782-90. (PMID: 21979382) Neuroimage. 2012 Jan 16;59(2):1514-23. (PMID: 21875674) Alzheimers Dement (Amst). 2019 Feb 22;11:170-179. (PMID: 30911598) Netw Neurosci. 2020 Feb 01;4(1):89-114. (PMID: 32043045) Neuroimage. 2004;23 Suppl 1:S208-19. (PMID: 15501092) Circulation. 2005 Dec 13;112(24):3722-8. (PMID: 16330686) Front Hum Neurosci. 2016 Jun 28;10:286. (PMID: 27445740) J Am Heart Assoc. 2016 Mar 16;5(3):e002731. (PMID: 26984255) Front Aging Neurosci. 2014 Apr 07;6:59. (PMID: 24778617) Magn Reson Med. 2004 Apr;51(4):736-43. (PMID: 15065246) J Neurol Sci. 2014 Aug 15;343(1-2):100-4. (PMID: 24916036) J Commun Disord. 2003 May-Jun;36(3):189-208. (PMID: 12742667) NMR Biomed. 2002 Nov-Dec;15(7-8):456-67. (PMID: 12489095) Biochim Biophys Acta. 2012 Mar;1822(3):386-400. (PMID: 21871957) |
فهرسة مساهمة: | Keywords: DWI; aging; arterial pulsatility; cardiovascular risk factors; working memory |
تواريخ الأحداث: | Date Created: 20200828 Latest Revision: 20200928 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7427001 |
DOI: | 10.3389/fnagi.2020.00245 |
PMID: | 32848715 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1663-4365 |
---|---|
DOI: | 10.3389/fnagi.2020.00245 |