دورية أكاديمية
أعرض في EDS

Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.

التفاصيل البيبلوغرافية
العنوان: Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.
المؤلفون: Conley AC; Department of Psychiatry, Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Karayanidis F; Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science, University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Jolly TAD; Functional Neuroimaging Laboratory, School of Psychology, Faculty of Science, University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia.; Hunter Medical Research Institute, Newcastle, NSW, Australia., Yang MH; Department of Psychology, National Cheng Kung University, Tainan, Taiwan.; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.; Department and Institute of Public health, National Cheng Kung University, Tainan, Taiwan., Hsieh S; Department of Psychology, National Cheng Kung University, Tainan, Taiwan.; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.; Department and Institute of Public health, National Cheng Kung University, Tainan, Taiwan.
المصدر: Frontiers in aging neuroscience [Front Aging Neurosci] 2020 Aug 07; Vol. 12, pp. 245. Date of Electronic Publication: 2020 Aug 07 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Aging is associated with an increased prevalence of vascular health conditions that are linked to a disruption in the cerebral vasculature and white matter microstructural organization. In people with cardiovascular risk factors, increased cerebral arterial pulsatility is associated with poorer white matter microstructural organization and cognitive functioning. This study examines the relationship among arterial pulsatility, white matter microstructural organization, and cognitive ability in a healthy adult lifespan sample. One hundred and eighty-nine adults were divided into a younger adult (<50 years, n = 97) and older adult (>50 years, n = 92). The latter were further subdivided into two subgroups with (CV+, n = 25) and without (CV-, n = 67) cardiovascular risk factors. Arterial pulsatility was measured using cardiac-gated phase-contrast flow quantification sequence and three indexes of whole-brain white matter microstructural organization [i.e., fractional anisotropy (FA), radial diffusivity (RaD), mean diffusivity (MD)] were derived from diffusion-weighted imaging (DWI). Cognitive ability was assessed using global cognitive functioning (MoCA) and a measure of working memory [sensitivity ( d' ) from a 2-back task]. Neither the whole group analysis nor the younger adult group showed an association between measures of arterial pulsatility, global white matter microstructural organization, and cognition. In older adults, higher MD and RaD were associated with increased arterial pulsatility and poorer working memory performance. The indirect pathway from arterial pulsatility to working memory performance via both MD and RaD measures was significant in this group. Interestingly, a comparison of CV+ and CV- subgroups showed that this mediating relationship was only evident in older adults with at least one CV risk factor. These findings are consistent with cardiovascular risk factors as underlying arterial, white matter, and cognitive decline in cognitively normal older adults.
(Copyright © 2020 Conley, Karayanidis, Jolly, Yang and Hsieh.)
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فهرسة مساهمة: Keywords: DWI; aging; arterial pulsatility; cardiovascular risk factors; working memory
تواريخ الأحداث: Date Created: 20200828 Latest Revision: 20200928
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7427001
DOI: 10.3389/fnagi.2020.00245
PMID: 32848715
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-4365
DOI:10.3389/fnagi.2020.00245