دورية أكاديمية
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Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration.

التفاصيل البيبلوغرافية
العنوان: Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration.
المؤلفون: Mahendra CK; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia., Tan LTH; Novel Bacteria and Drug Discovery Research Group, Microbiome and Bioresource Research Strength Jeffrey Cheah School of Medicine and Health Sciences, Monash University, 47500 Bandar Sunway, Malaysia., Pusparajah P; Medical Health and Translational Research Group, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia., Htar TT; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia., Chuah LH; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.; Advanced Engineering Platform, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia., Lee VS; Department of Chemistry, Drug Design and Development Research Group (DDDRG), Centre for Theoretical and Computational Physics, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia., Low LE; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310058, China., Tang SY; Advanced Engineering Platform, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia.; Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia., Chan KG; Division of Genetics and Molecular Biology, Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia.; International Genome Centre, Jiangsu University, Zhenjiang, China., Goh BH; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.; Health and Well-Being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway 47500, Malaysia.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2020 Aug 12; Vol. 2020, pp. 1904178. Date of Electronic Publication: 2020 Aug 12 (Print Publication: 2020).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Ultraviolet Rays*, Epithelial Cells/*radiation effects , Macular Degeneration/*pathology , Retinal Pigment Epithelium/*radiation effects, Apoptosis/radiation effects ; Epithelial Cells/pathology ; Humans ; Inflammasomes/metabolism ; Retinal Pigment Epithelium/pathology
مستخلص: Retinal pigment epithelial (RPE) cells are an essential part of the human eye because they not only mediate and control the transfer of fluids and solutes but also protect the retina against photooxidative damage and renew photoreceptor cells through phagocytosis. However, their function necessitates cumulative exposure to the sun resulting in UV damage, which may lead to the development of age-related macular degeneration (AMD). Several studies have shown that UVB induces direct DNA damage and oxidative stress in RPE cells by increasing ROS and dysregulating endogenous antioxidants. Activation of different signaling pathways connected to inflammation, cell cycle arrest, and intrinsic apoptosis was reported as well. Besides that, essential functions like phagocytosis, osmoregulation, and water permeability of RPE cells were also affected. Although the melanin within RPE cells can act as a photoprotectant, this photoprotection decreases with age. Nevertheless, the changes in lens epithelium-derived growth factor (LEDGF) and autophagic activity or application of bioactive compounds from natural products can reverse the detrimental effect of UVB. Additionally, in vivo studies on the whole retina demonstrated that UVB irradiation induces gene and protein level dysregulation, indicating cellular stress and aberrations in the chromosome level. Morphological changes like retinal depigmentation and drusen formation were noted as well which is similar to the etiology of AMD, suggesting the connection of UVB damage with AMD. Therefore, future studies, which include mechanism studies via in vitro or in vivo and other potential bioactive compounds, should be pursued for a better understanding of the involvement of UVB in AMD.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2020 Camille Keisha Mahendra et al.)
References: FEBS Lett. 2008 Sep 3;582(20):3097-102. (PMID: 18703055)
Cancer Res. 1998 Dec 1;58(23):5315-20. (PMID: 9850056)
Dermatoendocrinol. 2012 Jan 1;4(1):44-52. (PMID: 22870352)
Nat Protoc. 2016 Jul;11(7):1206-18. (PMID: 27281648)
Science. 2004 Oct 29;306(5697):885-8. (PMID: 15514162)
EMBO J. 2008 Apr 23;27(8):1243-54. (PMID: 18388864)
Invest Ophthalmol Vis Sci. 2004 Feb;45(2):668-74. (PMID: 14744913)
Neurochem Res. 2009 Nov;34(11):1924-34. (PMID: 19408115)
J Biol Chem. 2001 Nov 30;276(48):44688-94. (PMID: 11572873)
Cell Tissue Res. 2010 Mar;339(3):551-60. (PMID: 20140456)
Int J Mol Med. 2009 Jun;23(6):771-7. (PMID: 19424603)
Oxid Med Cell Longev. 2018 Nov 7;2018:4814928. (PMID: 30524656)
Biomed Res Int. 2017;2017:3681707. (PMID: 28321407)
Expert Opin Ther Targets. 2006 Dec;10(6):889-909. (PMID: 17105375)
Mol Cell Proteomics. 2004 Nov;3(11):1119-27. (PMID: 15367653)
Immunol Lett. 2012 Sep;147(1-2):29-33. (PMID: 22698681)
FEBS J. 2014 Dec;281(23):5251-64. (PMID: 25251993)
Free Radic Biol Med. 2001 Jul 15;31(2):256-65. (PMID: 11440838)
Exp Eye Res. 1996 Apr;62(4):399-408. (PMID: 8795458)
Pigment Cell Res. 1999 Feb;12(1):22-35. (PMID: 10193679)
Curr Mol Med. 2014 May;14(4):523-34. (PMID: 24694299)
Biochim Biophys Acta. 2015 Sep;1852(9):1833-45. (PMID: 26071645)
J Phys Chem B. 2007 Jul 19;111(28):7938-47. (PMID: 17580858)
J Mol Neurosci. 2012 Jan;46(1):122-37. (PMID: 21603979)
ISRN Ophthalmol. 2013 Jul 24;2013:632302. (PMID: 24558602)
Protein Cell. 2016 Mar;7(3):159-74. (PMID: 26936847)
J Photochem Photobiol B. 2013 Jul 5;124:34-41. (PMID: 23651647)
Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2988-95. (PMID: 10549662)
Biochem Biophys Res Commun. 2015 Dec 25;468(4):541-7. (PMID: 26505797)
Oncogene. 2011 Jan 20;30(3):313-22. (PMID: 20856205)
J Biol Chem. 2003 Jun 20;278(25):22432-6. (PMID: 12730222)
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2803-8. (PMID: 12766090)
Nat Genet. 2000 Jul;25(3):257-8. (PMID: 10888868)
Clin Ophthalmol. 2010 Feb 02;4:33-9. (PMID: 20169047)
Rev Physiol Biochem Pharmacol. 2003;148:1-80. (PMID: 12687402)
J Biol Chem. 2011 May 13;286(19):17248-58. (PMID: 21454509)
Cell Death Differ. 2004 Aug;11(8):915-23. (PMID: 15118763)
J Cell Biol. 1998 Jun 1;141(5):1277-86. (PMID: 9606218)
Photochem Photobiol. 2008 Sep-Oct;84(5):1294-7. (PMID: 18673326)
J Photochem Photobiol B. 2001 Nov 15;64(2-3):136-43. (PMID: 11744400)
Invest Ophthalmol Vis Sci. 2001 Nov;42(12):3041-6. (PMID: 11687553)
Mol Vis. 2017 Mar 05;23:60-89. (PMID: 28356702)
Exp Eye Res. 2001 Oct;73(4):479-91. (PMID: 11825020)
Nat Rev Mol Cell Biol. 2016 May;17(5):280-92. (PMID: 27033256)
Acta Ophthalmol. 2013 Sep;91(6):557-63. (PMID: 22974000)
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6665-70. (PMID: 20702817)
Int J Mol Sci. 2017 Mar 29;18(4):. (PMID: 28353645)
Free Radic Res. 2017 Oct;51(9-10):799-811. (PMID: 28969450)
Immunity. 2013 Jun 27;38(6):1142-53. (PMID: 23809161)
Biochemistry. 2001 Jan 30;40(4):1117-23. (PMID: 11170436)
Exp Eye Res. 2003 Jan;76(1):89-98. (PMID: 12589778)
Ageing Res Rev. 2015 Nov;24(Pt B):286-98. (PMID: 26369358)
Trends Biochem Sci. 2016 Dec;41(12):1012-1021. (PMID: 27669650)
ScientificWorldJournal. 2013 Dec 25;2013:178708. (PMID: 24453806)
Arch Ophthalmol. 2004 Apr;122(4):598-614. (PMID: 15078679)
Curr Eye Res. 2006 Sep;31(9):739-48. (PMID: 16966147)
Exp Eye Res. 1996 Feb;62(2):155-69. (PMID: 8698076)
Invest Ophthalmol Vis Sci. 2011 Nov 21;52(12):9047. (PMID: 22104197)
Carcinogenesis. 2001 Feb;22(2):287-94. (PMID: 11181450)
Dev Growth Differ. 2007 Feb;49(2):109-20. (PMID: 17335432)
Ophthalmol Retina. 2020 Jan;4(1):31-40. (PMID: 31649003)
Adv Clin Exp Med. 2015 Nov-Dec;24(6):1099-104. (PMID: 26771984)
Biochem Biophys Res Commun. 2001 May 18;283(4):943-55. (PMID: 11350077)
Photochem Photobiol. 2019 Jan;95(1):183-191. (PMID: 29752877)
Ophthalmologica. 2005 Jul-Aug;219(4):214-21. (PMID: 16088240)
Mol Med Rep. 2012 Jan;5(1):54-9. (PMID: 21909619)
J Photochem Photobiol B. 2007 Jul 27;88(1):21-8. (PMID: 17566755)
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2422-32. (PMID: 12766039)
Biochem Biophys Res Commun. 2013 Sep 6;438(4):739-45. (PMID: 23916613)
Exp Eye Res. 2007 Apr;84(4):772-80. (PMID: 17313944)
Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3268-75. (PMID: 10586952)
Photochem Photobiol. 2006 Jul-Aug;82(4):1024-9. (PMID: 17205626)
Biochemistry (Mosc). 2017 Aug;82(8):916-924. (PMID: 28941459)
Nat Immunol. 2012 Mar 19;13(4):333-42. (PMID: 22430786)
Front Pharmacol. 2018 Feb 19;9:102. (PMID: 29515440)
Cell Mol Immunol. 2016 Mar;13(2):148-59. (PMID: 26549800)
J Biol Chem. 2006 Jun 30;281(26):17999-8007. (PMID: 16644728)
Front Microbiol. 2015 Nov 26;6:1316. (PMID: 26635777)
Free Radic Biol Med. 1999 Mar;26(5-6):518-25. (PMID: 10218640)
Oncotarget. 2015 Mar 10;6(7):5072-87. (PMID: 25669984)
J Tissue Eng. 2016 Jul 12;7:2041731416650838. (PMID: 27493715)
Metabolism. 2001 Jan;50(1):60-4. (PMID: 11172476)
Curr Eye Res. 1998 Aug;17(8):851-7. (PMID: 9724002)
Invest Ophthalmol Vis Sci. 1986 Jul;27(7):1063-7. (PMID: 3721785)
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E2950-7. (PMID: 23878245)
J Photochem Photobiol B. 1993 Aug;19(3):201-4. (PMID: 8229462)
Mol Med Rep. 2017 Jul;16(1):730-736. (PMID: 28560393)
Pigment Cell Melanoma Res. 2011 Feb;24(1):21-34. (PMID: 20846177)
J Biol Chem. 2000 Dec 15;275(50):39625-30. (PMID: 11006290)
J Proteome Res. 2006 Oct;5(10):2599-610. (PMID: 17022631)
Sci Rep. 2016 May 06;6:25525. (PMID: 27151674)
Eye Contact Lens. 2011 Jul;37(4):206-13. (PMID: 21670692)
J Cell Biol. 2013 Nov 25;203(4):563-74. (PMID: 24385483)
Nat Rev Mol Cell Biol. 2007 Sep;8(9):741-52. (PMID: 17717517)
PLoS One. 2013 Dec 27;8(12):e84171. (PMID: 24386346)
J Photochem Photobiol B. 2018 Sep;186:9-16. (PMID: 29982095)
J Neurosci. 1997 Feb 15;17(4):1425-34. (PMID: 9006984)
Nutr Neurosci. 2016;19(3):95-101. (PMID: 25752849)
J Cataract Refract Surg. 2008 Jul;34(7):1161-6. (PMID: 18571086)
Toxicol In Vitro. 2013 Sep;27(6):1728-36. (PMID: 23673314)
J Natl Cancer Inst. 1982 Jul;69(1):287-302. (PMID: 6285062)
Int J Mol Sci. 2016 Jan 08;17(1):. (PMID: 26760997)
Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1945-52. (PMID: 10845621)
Photochem Photobiol. 2002 Feb;75(2):184-90. (PMID: 11883606)
Graefes Arch Clin Exp Ophthalmol. 2001 Jul;239(7):501-8. (PMID: 11521694)
Exp Eye Res. 2014 Sep;126:51-60. (PMID: 24780752)
Invest Ophthalmol Vis Sci. 2002 Jul;43(7):2165-8. (PMID: 12091412)
Exp Eye Res. 2002 Apr;74(4):513-22. (PMID: 12076095)
Dermatol Online J. 2017 Nov 15;23(11):. (PMID: 29447629)
N Engl J Med. 1995 Nov 9;333(19):1260-6. (PMID: 7566004)
PLoS One. 2009;4(1):e4160. (PMID: 19129916)
Ann N Y Acad Sci. 2006 Dec;1091:17-33. (PMID: 17341599)
Invest Ophthalmol Vis Sci. 2011 Nov 04;52(12):8614-20. (PMID: 21960553)
Int J Pharm. 2009 Mar 31;370(1-2):87-92. (PMID: 19084584)
J Immunol. 2012 Dec 15;189(12):5508-12. (PMID: 23144495)
Graefes Arch Clin Exp Ophthalmol. 2001 Apr;239(4):302-9. (PMID: 11450495)
Invest Ophthalmol Vis Sci. 1978 Jul;17(7):601-7. (PMID: 669891)
Eye (Lond). 2001 Jun;15(Pt 3):384-9. (PMID: 11450762)
Cancer Lett. 2006 Apr 28;235(2):248-59. (PMID: 15975709)
Exp Eye Res. 2011 Jul;93(1):29-39. (PMID: 21524648)
Glycoconj J. 2002 May-Jun;19(4-5):275-85. (PMID: 12975606)
Oncogene. 2013 Oct 10;32(41):4892-902. (PMID: 23178494)
Invest Ophthalmol Vis Sci. 2001 Apr;42(5):1087-95. (PMID: 11274090)
J Clin Invest. 2015 Jan;125(1):25-32. (PMID: 25654547)
Int J Mol Sci. 2015 Mar 12;16(3):5789-802. (PMID: 25775159)
Autophagy. 2014;10(11):1989-2005. (PMID: 25484094)
J Transl Med. 2018 Mar 13;16(1):63. (PMID: 29534722)
J Biomed Biotechnol. 2010;2010:190724. (PMID: 20182540)
Invest Ophthalmol Vis Sci. 2004 Feb;45(2):694-701. (PMID: 14744916)
F1000Prime Rep. 2014 May 06;6:29. (PMID: 24860651)
Redox Biol. 2013 Jan 18;1:45-9. (PMID: 24024136)
Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1342-7. (PMID: 17325182)
Cutan Ocul Toxicol. 2015;34(3):189-94. (PMID: 25198400)
Evid Based Complement Alternat Med. 2015;2015:896314. (PMID: 26294929)
Zebrafish. 2015 Feb;12(1):21-32. (PMID: 25517103)
Mol Aspects Med. 2012 Aug;33(4):399-417. (PMID: 22510306)
J Agric Food Chem. 2016 Jan 20;64(2):416-24. (PMID: 26708928)
Eur J Ophthalmol. 2011;21 Suppl 6:S3-9. (PMID: 23264323)
Autophagy. 2008 Oct;4(7):969-71. (PMID: 18758234)
Mol Vis. 2007 Mar 01;13:318-29. (PMID: 17392682)
FASEB J. 2020 May;34(5):6437-6448. (PMID: 32190930)
Food Funct. 2016 Feb;7(2):1067-76. (PMID: 26781209)
Invest Ophthalmol Vis Sci. 2011 May 02;52(6):2868-78. (PMID: 21228388)
Mol Aspects Med. 2012 Aug;33(4):295-317. (PMID: 22542780)
Cell Immunol. 2012;273(1):79-84. (PMID: 22169226)
Free Radic Biol Med. 2014 Apr;69:219-28. (PMID: 24486344)
Curr Mol Med. 2010 Dec;10(9):802-23. (PMID: 21091424)
J Appl Toxicol. 1992 Jun;12(3):191-2. (PMID: 1629514)
Free Radic Biol Med. 2018 Mar;117:238-246. (PMID: 29427790)
Br J Dermatol. 2001 Oct;145(4):535-45. (PMID: 11703278)
PLoS One. 2014 Jul 25;9(7):e103364. (PMID: 25062253)
Immunity. 2017 Apr 18;46(4):649-659. (PMID: 28410991)
Nature. 2011 Jan 13;469(7329):221-5. (PMID: 21124315)
Autophagy. 2005 Jul;1(2):84-91. (PMID: 16874052)
Exp Eye Res. 2006 May;82(5):741-52. (PMID: 16325179)
Prog Retin Eye Res. 2007 May;26(3):263-301. (PMID: 17258931)
Cancer Gene Ther. 2008 Apr;15(4):241-51. (PMID: 18202716)
Environ Toxicol. 2018 Jan;33(1):52-62. (PMID: 29044990)
Nat Med. 2012 May;18(5):791-8. (PMID: 22484808)
Exp Cell Res. 1993 Feb;204(2):311-20. (PMID: 7679997)
Invest Ophthalmol Vis Sci. 1995 Apr;36(5):955-64. (PMID: 7706045)
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3644-55. (PMID: 16877439)
Biochim Biophys Acta. 2015 Feb;1853(2):396-408. (PMID: 25450976)
المشرفين على المادة: 0 (Inflammasomes)
تواريخ الأحداث: Date Created: 20200829 Date Completed: 20210514 Latest Revision: 20210514
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7443017
DOI: 10.1155/2020/1904178
PMID: 32855763
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2020/1904178