دورية أكاديمية
Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study.
العنوان: | Prognostic role of pre-sarcopenia and body composition with long-term outcomes in obstructive colorectal cancer: a retrospective cohort study. |
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المؤلفون: | Lee CS; Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Graduate School of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Won DD; Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Oh SN; Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.; Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Lee YS; Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Lee IK; Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Kim IH; Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Choi MH; Department of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea., Oh ST; Department of Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271, Cheonbo-Ro, Uijeongbu-si, Gyeonggi-do, 11765, Seoul, Republic of Korea. stoh@catholic.ac.kr. |
المصدر: | World journal of surgical oncology [World J Surg Oncol] 2020 Aug 28; Vol. 18 (1), pp. 230. Date of Electronic Publication: 2020 Aug 28. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101170544 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7819 (Electronic) Linking ISSN: 14777819 NLM ISO Abbreviation: World J Surg Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, 2003- |
مواضيع طبية MeSH: | Colonic Neoplasms*/pathology , Colorectal Neoplasms*/complications , Colorectal Neoplasms*/pathology , Sarcopenia*/diagnosis , Sarcopenia*/diagnostic imaging, Body Composition ; Humans ; Muscle, Skeletal/pathology ; Prognosis ; Prospective Studies ; Retrospective Studies |
مستخلص: | Background: The clinical significance of pre-sarcopenia in colorectal cancer obstruction has not yet been described. The present study aimed to determine the short- and long-term oncologic impacts of pre-sarcopenia in obstructive colorectal cancer. Methods: We retrospectively analyzed 214 patients with obstructive colon cancer between January 2004 and December 2013. Initial staging computed tomography (CT) scans identified pre-sarcopenia and visceral obesity by measuring the muscle and visceral fat areas at the third lumbar vertebra level. Both short-term postoperative and long-term oncologic outcomes were analyzed. Results: Among all 214 patients, 71 (33.2%) were diagnosed with pre-sarcopenia. Pre-sarcopenia had a negative oncologic impact in both disease-free survival (DFS) and overall survival (OS), (hazard ratio [HR] = 1.86, 95% confidence interval [CI] 1.04-3.13, p = 0.037, and HR = 1.92, CI 1.02-3.60, p = 0.043, respectively). Visceral adiposity, body mass index (BMI), and neutrophil-lymphocyte ratio (NLR) did not significantly impact DFS and OS. Conclusion: Pre-sarcopenia is a clinical factor significantly associated with OS and DFS but not with short-term complications in obstructive colorectal cancer. In future, prospective studies should incorporate body composition data in patient risk assessments and oncologic prediction tools. |
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فهرسة مساهمة: | Keywords: Body composition; Colorectal neoplasms; Sarcopenia; Self-expandable metallic stents |
تواريخ الأحداث: | Date Created: 20200830 Date Completed: 20210514 Latest Revision: 20210514 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7456379 |
DOI: | 10.1186/s12957-020-02006-3 |
PMID: | 32859211 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1477-7819 |
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DOI: | 10.1186/s12957-020-02006-3 |