دورية أكاديمية
أعرض في EDS

Intracranial artery calcifications: Risk factors and association with cardiovascular disease and cognitive function.

التفاصيل البيبلوغرافية
العنوان: Intracranial artery calcifications: Risk factors and association with cardiovascular disease and cognitive function.
المؤلفون: Golüke NMS; University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, The Netherlands; Tergooi Hospital, Department of Geriatrics, Blaricum, The Netherlands. Electronic address: n.m.s.goluke-2@umcutrecht.nl., de Brouwer EJM; University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, The Netherlands; Tergooi Hospital, Department of Geriatrics, Blaricum, The Netherlands., de Jonghe A; Tergooi Hospital, Department of Geriatrics, Blaricum, The Netherlands., Claus JJ; Tergooi Hospital, Department of Neurology, Blaricum, The Netherlands., Staekenborg SS; Tergooi Hospital, Department of Neurology, Blaricum, The Netherlands., Emmelot-Vonk MH; University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, The Netherlands., de Jong PA; University Medical Center Utrecht, Utrecht University, Department of Radiology, Utrecht, The Netherlands., Koek HL; University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, The Netherlands.
المصدر: Journal of neuroradiology = Journal de neuroradiologie [J Neuroradiol] 2022 May; Vol. 49 (3), pp. 281-287. Date of Electronic Publication: 2020 Aug 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Masson Country of Publication: France NLM ID: 7705086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0150-9861 (Print) Linking ISSN: 01509861 NLM ISO Abbreviation: J Neuroradiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Paris, New York, Masson.
مواضيع طبية MeSH: Cardiovascular Diseases*/complications , Cardiovascular Diseases*/diagnostic imaging , Cardiovascular Diseases*/epidemiology , Carotid Artery Diseases*/complications , Myocardial Infarction*/complications , Stroke*/complications , Vascular Calcification*/complications , Vascular Calcification*/diagnostic imaging , Vascular Calcification*/epidemiology, Aged ; Carotid Artery, Internal ; Cognition ; Female ; Humans ; Male ; Risk Factors
مستخلص: Background and Aims: we know little about clinical outcomes of arterial calcifications. This study investigates the risk factors of intracranial artery calcifications and its association with cardiovascular disease and cognitive function.
Methods: patients were recruited from a Dutch memory clinic, between April 2009 and April 2015. The intracranial internal carotid artery (iICA) and basilar artery were analysed on the presence of calcifications. Calcifications in the iICA were also assessed on severity and location in the tunica intima or tunica media. Using logistic regression, risk factors of intracranial artery calcifications were analysed, as well as the association of these calcifications with cardiovascular disease, cognitive function and type of cognitive disorder (including subjective cognitive impairment, mild cognitive impairment and dementia). Cognitive function was assessed with the Cambridge Cognitive Examination.
Results: 1992 patients were included (median age: 78.2 years, ±40% male). The majority of patients had calcifications in the iICA (±95%). Basilar artery calcifications were less prevalent (±8%). Risk factors for cerebral intracranial calcifications were age (p < 0.001), diabetes mellitus (medial iICA, p = 0.004), hypertension (intimal iICA, p < 0.001) and basilar artery, p = 0.019) and smoking (intimal iICA, p = 0.008). iICA calcifications were associated with stroke and intimal calcifications also with myocardial infarction. Intracranial artery calcifications were not associated with cognitive function or type of cognitive disorder.
Conclusion: the majority of memory clinic patients had intracranial artery calcifications. Cardiovascular risk factors are differentially related to medial or intimal iICA calcifications. iICA calcifications were associated with myocardial infarction and stroke, but not with cognitive outcomes.
(Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Arterial calcifications; Cardiovascular disease; Kockelkoren score; Risk factors; iICA
تواريخ الأحداث: Date Created: 20200830 Date Completed: 20220517 Latest Revision: 20220517
رمز التحديث: 20231215
DOI: 10.1016/j.neurad.2020.08.001
PMID: 32860807
قاعدة البيانات: MEDLINE
الوصف
تدمد:0150-9861
DOI:10.1016/j.neurad.2020.08.001