دورية أكاديمية
Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy.
| العنوان: | Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. |
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| المؤلفون: | Sperry J; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Condro MC; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA., Guo L; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.; Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Braas D; UCLA Metabolomics Center, UCLA, Los Angeles, CA, USA., Vanderveer-Harris N; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA., Kim KKO; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Pope WB; Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Divakaruni AS; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA., Lai A; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Department of Neurology, UCLA, Los Angeles, CA, USA., Christofk H; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Department of Biological Chemistry, UCLA, Los Angeles, CA, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA., Castro MG; Department of Neurosurgery, Department of Cell and Developmental Biology, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Lowenstein PR; Department of Neurosurgery, Department of Cell and Developmental Biology, Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Le Belle JE; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA., Kornblum HI; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.; Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA. |
| المصدر: | IScience [iScience] 2020 Aug 13; Vol. 23 (9), pp. 101453. Date of Electronic Publication: 2020 Aug 13 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
| مستخلص: | Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in GBM and assessed the role of fatty acid oxidation (FAO) in promoting GBM propagation. In vitro assays revealed FA utilization throughout the GBM metabolome and growth inhibition in nearly every cell line in a broad spectrum of patient-derived glioma cells treated with FAO inhibitors. In vivo assessments revealed that knockdown of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme for FAO, reduced the rate of tumor growth and increased survival. However, the unrestricted ketogenic diet did not reduce tumor growth and for some models significantly reduced survival. Altogether, these data highlight important roles for FA and ketone body metabolism that could serve to improve targeted therapies in GBM. Competing Interests: The authors declare no competing interests. (© 2020 The Authors.) |
| معلومات مُعتمدة: | P50 CA211015 United States CA NCI NIH HHS; R01 AR070245 United States AR NIAMS NIH HHS; R01 CA215185 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Cancer; Diet; Pathophysiology |
| تواريخ الأحداث: | Date Created: 20200830 Latest Revision: 20230816 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7471621 |
| DOI: | 10.1016/j.isci.2020.101453 |
| PMID: | 32861192 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2589-0042 |
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| DOI: | 10.1016/j.isci.2020.101453 |