دورية أكاديمية
أعرض في EDS

A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS.

التفاصيل البيبلوغرافية
العنوان: A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS.
المؤلفون: Haliloglu M; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey., Bilgili B; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey., Bilginer H; Department of Infectious Disease, School of Medicine, Marmara University, Istanbul, Turkey., Kasapoglu US; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey., Sayan I; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey., Aslan MS; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey., Durmusoglu LM; Department of Infectious Disease, School of Medicine, Marmara University, Istanbul, Turkey., Cinel I; Department of Anesthesiology and Intensive Care, School of Medicine, Marmara University, Istanbul, Turkey.
المصدر: Archives of medical science : AMS [Arch Med Sci] 2020 Aug 10; Vol. 16 (5), pp. 1040-1048. Date of Electronic Publication: 2020 Aug 10 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Termedia Pub. House Country of Publication: Poland NLM ID: 101258257 Publication Model: eCollection Cited Medium: Print ISSN: 1734-1922 (Print) Linking ISSN: 17341922 NLM ISO Abbreviation: Arch Med Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Poznań, Poland] : Termedia Pub. House, [2005]-
مستخلص: Introduction: The Clinical Pulmonary Infection Score (CPIS) based on chest X-ray has been developed to facilitate clinical diagnosis of ventilator-associated pneumonia (VAP); however, this scoring system has a low diagnostic performance. We developed the Lung Ultrasound and Pentraxin-3 Pulmonary Infection Score (LUPPIS) for early diagnosis of VAP and evaluated the performance of this new scoring system.
Material and Methods: In a prospective study of 78 patients with suspected VAP, we assessed the detection accuracy of LUPPIS for pneumonia in adult patients. We also evaluated the diagnostic performance of pentraxin-3 (PTX-3) findings of infection. On the day of the study, lung ultrasound was performed, PTX-3 levels were determined, and an endotracheal aspirate was obtained for Gram staining and culture.
Results: No significant differences were found between groups with respect to age, mechanical ventilation time, APACHE II score, or SOFA score ( p > 0.05). Procalcitonin and PTX-3 levels were significantly higher in the VAP (+) group ( p < 0.001 and p < 0.001, respectively). The threshold for LUPPIS in differentiating VAP (+) patients from VAP (-) patients was > 7. In predicting VAP, LUPPIS > 7 (sensitivity of 84%, specificity of 87.7%) was superior to CPIS > 6 (sensitivity of 40.1%, specificity of 84.5%).
Conclusions: LUPPIS appears to provide better results in the prediction of VAP compared to CPIS, and the importance of lung ultrasound and PTX-3 is emphasized, which is a distinctive property of LUPPIS.
Competing Interests: The authors declare no conflict of interest.
(Copyright: © 2020 Termedia & Banach.)
References: BMC Med Educ. 2009 Jan 12;9:3. (PMID: 19138397)
Clin Infect Dis. 2016 Sep 1;63(5):e61-e111. (PMID: 27418577)
J Immunol. 2011 May 1;186(9):5425-34. (PMID: 21441447)
Minerva Anestesiol. 2014 May;80(5):517-25. (PMID: 24299918)
Annu Rev Immunol. 2003;21:547-78. (PMID: 12524383)
Curr Opin Crit Care. 2008 Feb;14(1):70-4. (PMID: 18195629)
Antimicrob Agents Chemother. 2010 Oct;54(10):4513-5. (PMID: 20625145)
Chest. 2002 Dec;122(6):2115-21. (PMID: 12475855)
Intensive Care Med. 2015 Sep;41(9):1638-47. (PMID: 26160727)
Intensive Care Med. 2008 Jan;34(1):17-60. (PMID: 18058085)
Anesthesiology. 2008 Jan;108(1):40-5. (PMID: 18156880)
Chest. 1992 Feb;101(2):458-63. (PMID: 1735272)
Crit Care. 2006 Feb;10(1):R11. (PMID: 16420655)
Adv Exp Med Biol. 2012;946:1-20. (PMID: 21948359)
Am J Respir Crit Care Med. 2012 Sep 15;186(6):546-52. (PMID: 22822025)
N Engl J Med. 2008 Feb 14;358(7):716-27. (PMID: 18272895)
Clin Chem Lab Med. 2013 Apr;51(4):907-13. (PMID: 23152412)
Lancet Infect Dis. 2013 Aug;13(8):665-71. (PMID: 23622939)
Intensive Care Med. 2012 Apr;38(4):577-91. (PMID: 22392031)
Heart Lung. 2011 Jul-Aug;40(4):293-8. (PMID: 21419491)
PLoS One. 2013 Sep 09;8(9):e73119. (PMID: 24039869)
Intensive Care Med. 2007 Apr;33(4):639-44. (PMID: 17333118)
PLoS One. 2013;8(1):e53661. (PMID: 23341967)
Crit Care. 2008;12(3):R62. (PMID: 18454864)
Crit Care Med. 2012 Jul;40(7):2064-72. (PMID: 22584759)
Thorax. 1999 Oct;54(10):867-73. (PMID: 10491448)
Crit Care. 2014 Oct 15;18(5):562. (PMID: 25314919)
Chest. 1994 Mar;105(3):885-7. (PMID: 8131557)
Am J Respir Crit Care Med. 1998 Feb;157(2):531-9. (PMID: 9476869)
J Immunol. 2008 Mar 1;180(5):3391-8. (PMID: 18292565)
Am J Respir Crit Care Med. 2011 Nov 15;184(10):1133-9. (PMID: 21852541)
Chest. 2014 Dec;146(6):1578-1585. (PMID: 25144666)
J Crit Care. 2006 Mar;21(1):56-65. (PMID: 16616625)
Chest. 2000 Jul;118(1):146-55. (PMID: 10893372)
Heart Lung. 2013 Mar-Apr;42(2):139-45. (PMID: 23273657)
J Immunol. 2005 Dec 15;175(12):8303-11. (PMID: 16339571)
Adv Intern Med. 1982;27:345-72. (PMID: 7041546)
Ann Intern Med. 2003 Jan 7;138(1):W1-12. (PMID: 12513067)
J Biol Chem. 1992 Nov 5;267(31):22190-7. (PMID: 1429570)
Nat Immunol. 2010 Apr;11(4):328-34. (PMID: 20208538)
Chest. 2016 Apr;149(4):969-80. (PMID: 26836896)
Am J Respir Crit Care Med. 2003 Jul 15;168(2):173-9. (PMID: 12738607)
J Biol Chem. 1997 Dec 26;272(52):32817-23. (PMID: 9407058)
Crit Care. 2007;11(1):205. (PMID: 17316468)
Anesthesiology. 2004 Jan;100(1):9-15. (PMID: 14695718)
N Engl J Med. 2014 Jan 23;370(4):341-51. (PMID: 24450892)
Intensive Care Med. 2004 May;30(5):735-8. (PMID: 14991088)
Am J Respir Crit Care Med. 2011 Feb 1;183(3):341-7. (PMID: 20851923)
Am Rev Respir Dis. 1991 May;143(5 Pt 1):1121-9. (PMID: 2024824)
Crit Care Med. 2011 Dec;39(12):2736-42. (PMID: 21765351)
فهرسة مساهمة: Keywords: Clinical Pulmonary Infection Score; lung ultrasound; pentraxin-3; ventilator-associated pneumonia
تواريخ الأحداث: Date Created: 20200901 Latest Revision: 20220416
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7444718
DOI: 10.5114/aoms.2020.97965
PMID: 32863992
قاعدة البيانات: MEDLINE
الوصف
تدمد:1734-1922
DOI:10.5114/aoms.2020.97965