دورية أكاديمية
أعرض في EDS

Serotonergic modulation of visual neurons in Drosophila melanogaster.

التفاصيل البيبلوغرافية
العنوان: Serotonergic modulation of visual neurons in Drosophila melanogaster.
المؤلفون: Sampson MM; UCLA, Hatos Center for Neuropharmacology, Los Angeles, CA, United States of America.; UCLA, Molecular Toxicology Interdepartmental Program, Los Angeles, CA, United States of America., Myers Gschweng KM; UCLA, Hatos Center for Neuropharmacology, Los Angeles, CA, United States of America.; UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States of America., Hardcastle BJ; UCLA, Department of Integrative Biology and Physiology, Los Angeles, CA, United States of America., Bonanno SL; UCLA, Hatos Center for Neuropharmacology, Los Angeles, CA, United States of America.; UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States of America., Sizemore TR; Department of Biology, West Virginia University, Morgantown, WV, United States of America., Arnold RC; UCLA, Hatos Center for Neuropharmacology, Los Angeles, CA, United States of America.; UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States of America., Gao F; UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States of America., Dacks AM; Department of Biology, West Virginia University, Morgantown, WV, United States of America., Frye MA; UCLA, Department of Integrative Biology and Physiology, Los Angeles, CA, United States of America., Krantz DE; UCLA, Hatos Center for Neuropharmacology, Los Angeles, CA, United States of America.; UCLA, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, United States of America.
المصدر: PLoS genetics [PLoS Genet] 2020 Aug 31; Vol. 16 (8), pp. e1009003. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Receptor, Serotonin, 5-HT1B/*genetics , Receptors, Serotonin, 5-HT1/*genetics , Receptors, Serotonin, 5-HT2/*genetics , Serotonergic Neurons/*metabolism , Serotonin/*metabolism, Animals ; Circadian Rhythm/genetics ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Gene Expression Regulation/genetics ; Interneurons/metabolism ; Membrane Proteins/genetics ; Nerve Tissue Proteins/genetics ; Neurotransmitter Agents/genetics ; Receptors, Serotonin/genetics ; Serotonin/genetics ; Visual Perception/genetics
مستخلص: Sensory systems rely on neuromodulators, such as serotonin, to provide flexibility for information processing as stimuli vary, such as light intensity throughout the day. Serotonergic neurons broadly innervate the optic ganglia of Drosophila melanogaster, a widely used model for studying vision. It remains unclear whether serotonin modulates the physiology of interneurons in the optic ganglia. To address this question, we first mapped the expression patterns of serotonin receptors in the visual system, focusing on a subset of cells with processes in the first optic ganglion, the lamina. Serotonin receptor expression was found in several types of columnar cells in the lamina including 5-HT2B in lamina monopolar cell L2, required for spatiotemporal luminance contrast, and both 5-HT1A and 5-HT1B in T1 cells, whose function is unknown. Subcellular mapping with GFP-tagged 5-HT2B and 5-HT1A constructs indicated that these receptors localize to layer M2 of the medulla, proximal to serotonergic boutons, suggesting that the medulla neuropil is the primary site of serotonergic regulation for these neurons. Exogenous serotonin increased basal intracellular calcium in L2 terminals in layer M2 and modestly decreased the duration of visually induced calcium transients in L2 neurons following repeated dark flashes, but otherwise did not alter the calcium transients. Flies without functional 5-HT2B failed to show an increase in basal calcium in response to serotonin. 5-HT2B mutants also failed to show a change in amplitude in their response to repeated light flashes but other calcium transient parameters were relatively unaffected. While we did not detect serotonin receptor expression in L1 neurons, they, like L2, underwent serotonin-induced changes in basal calcium, presumably via interactions with other cells. These data demonstrate that serotonin modulates the physiology of interneurons involved in early visual processing in Drosophila.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: R01 EY026031 United States EY NEI NIH HHS; R01 MH114017 United States MH NIMH NIH HHS; F99 NS113454 United States NS NINDS NIH HHS; R01 MH107390 United States MH NIMH NIH HHS; R01 DC016293 United States DC NIDCD NIH HHS; R03 DC013997 United States DC NIDCD NIH HHS
المشرفين على المادة: 0 (Drosophila Proteins)
0 (Membrane Proteins)
0 (Nerve Tissue Proteins)
0 (Neurotransmitter Agents)
0 (Receptor, Serotonin, 5-HT1B)
0 (Receptors, Serotonin)
0 (Receptors, Serotonin, 5-HT1)
0 (Receptors, Serotonin, 5-HT2)
0 (ogre protein, Drosophila)
333DO1RDJY (Serotonin)
تواريخ الأحداث: Date Created: 20200901 Date Completed: 20200923 Latest Revision: 20210507
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7485980
DOI: 10.1371/journal.pgen.1009003
PMID: 32866139
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7404
DOI:10.1371/journal.pgen.1009003