دورية أكاديمية
أعرض في EDS

Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein.

التفاصيل البيبلوغرافية
العنوان: Short-term effect of low-dose colchicine on inflammatory biomarkers, lipids, blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein.
المؤلفون: Fiolet ATL; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.; Dutch Network for Cardiovascular Research, Utrecht, The Netherlands.; The Netherlands Heart Institute, Utrecht, The Netherlands., Silvis MJM; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., Opstal TSJ; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands., Bax WA; Department of Internal Medicine, Northwest Clinics, Alkmaar, The Netherlands., van der Horst FAL; Department of Clinical Chemistry, Haga Zorggroep, Delft, The Netherlands., Mosterd A; Dutch Network for Cardiovascular Research, Utrecht, The Netherlands.; Department of Cardiology, Meander Medisch Centrum, Amersfoort, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., de Kleijn D; Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands., Cornel JH; Dutch Network for Cardiovascular Research, Utrecht, The Netherlands.; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands.; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
المصدر: PloS one [PLoS One] 2020 Aug 31; Vol. 15 (8), pp. e0237665. Date of Electronic Publication: 2020 Aug 31 (Print Publication: 2020).
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: C-Reactive Protein/*analysis , Colchicine/*administration & dosage , Coronary Artery Disease/*drug therapy , Inflammation/*drug therapy, Aged ; Biomarkers/blood ; Chronic Disease/drug therapy ; Colchicine/adverse effects ; Coronary Artery Disease/blood ; Coronary Artery Disease/immunology ; Drug Administration Schedule ; Female ; Glomerular Filtration Rate/drug effects ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/immunology ; Leukocyte Count ; Lipid Metabolism/drug effects ; Male ; Middle Aged ; Platelet Count ; Prospective Studies ; Treatment Outcome
مستخلص: Aims: Inflammation plays a pivotal role in atherothrombosis. Colchicine is an anti-inflammatory drug that may attenuate this process. Cardiovascular protective effects of anti-inflammatory drugs, however, seem to be limited to patients with a biochemical response. We therefore investigated whether short-term exposure to colchicine reduced inflammatory markers and whether additional laboratory changes occur in patients with chronic coronary artery disease.
Methods & Results: In 138 consecutive patients with chronic coronary artery disease and a high sensitivity C-reactive Protein (hs-CRP) ≥ 2 mg/L, inflammatory markers, lipids, haematologic parameters and renal function were measured at baseline and after 30 days exposure to colchicine 0.5mg once daily. Hs-CRP decreased from baseline 4.40 mg/L (interquartile range [IQR] 2.83-6.99 mg/L) to 2.33 mg/L (IQR 1.41-4.17, median of the differences -1.66 mg/L, 95% confidence interval [CI] -2.17 - -1.22 mg/L, p-value <0.01), corresponding to a median change from baseline of -40%. Interleukin-6 decreased from 2.51 ng/L (IQR 1.59-4.32 ng/L) to 2.22 ng/L (median of the differences -0.36 ng/L, 95%CI -0.70 - -0.01 ng/L, p-value 0.04), corresponding to a median change from baseline of -16%. No clinically relevant changes in lipid fractions were observed. Both leukocyte and thrombocyte count decreased (median change from baseline -7% and -4% respectively). Estimated glomerular filtration rate decreased with a mean change from baseline of -2%.
Conclusion: In patients with chronic coronary artery disease and elevated hs-CRP, one-month exposure to colchicine 0.5 mg once daily was associated with a reduction of inflammatory markers. A small effect was seen on white blood cell count and platelet count, as well as a small decrease in estimated glomerular filtration rate.
Competing Interests: None of the authors has any financial or non-financial competing interest in relation to the research currently provided. The authors are all employed by local and academic hospitals. Additional funding for the research was provided by means of a governmental grant (The Netherlands Organisation for Health Research and Development [grant number 848015014]) and in-kind contributions from the research personnel from the participating sites. The authors received the drugs free-of-charge by TioPharma (Oud-Beijerland, the Netherlands). This commercial funder had no role in design of the study, accruement of the data, analysis of the data, drafting or reviewing of the manuscript or submission of the manuscript. There were no restrictions in interpretation or publication of the data instituted by the supplier of the drug or the governmental grant. None of the authors has financial ties with the supplier of the drugs. None of the authors has paid endorsements with the funder of the drug for consultative or marketing purposes. There are no authors with (pending) patents, stocks or shares related to the mechanisms or compounds described in the manuscript. No reimbursements for travel or educational purposes were provided by the funder of the drug. None of the authors serves or has served on the Editorial Board of PLOS ONE. None of the authors have acted as an expert witness in relevant legal proceedings. None of the authors sits or sat on a committee for an organization that may benefit from publication of the paper. None of the authors is employed as lobbyist or within advocacy companies.
References: BMJ. 2011 Feb 15;342:d548. (PMID: 21325005)
Eur Heart J. 2018 Oct 7;39(38):3499-3507. (PMID: 30165610)
Circulation. 2005 Nov 22;112(21):3272-9. (PMID: 16286589)
Semin Arthritis Rheum. 1998 Aug;28(1):48-59. (PMID: 9726336)
Semin Arthritis Rheum. 2009 Jun;38(6):411-9. (PMID: 18973929)
J Thromb Thrombolysis. 2012 Jan;33(1):88-94. (PMID: 21918905)
Am J Physiol. 1999 Jul;277(1):H100-6. (PMID: 10409187)
J Rheumatol. 2012 Jul;39(7):1458-64. (PMID: 22660810)
Lancet. 2012 Mar 31;379(9822):1214-24. (PMID: 22421340)
JACC Heart Fail. 2014 Apr;2(2):131-7. (PMID: 24720919)
Arthritis Rheum. 1970 Jan-Feb;13(1):1-9. (PMID: 5439313)
Eur Heart J. 2016 Jul 01;37(25):1959-67. (PMID: 26705388)
Nat Rev Immunol. 2016 Jul;16(7):407-20. (PMID: 27291964)
J Am Coll Cardiol. 2013 Jan 29;61(4):404-410. (PMID: 23265346)
Scand J Gastroenterol. 1994 Apr;29(4):346-51. (PMID: 8047810)
J Am Heart Assoc. 2015 Aug 24;4(8):e002128. (PMID: 26304941)
Am Heart J. 2019 Sep;215:62-69. (PMID: 31284074)
N Engl J Med. 2019 Dec 26;381(26):2497-2505. (PMID: 31733140)
Joint Bone Spine. 2006 Dec;73(6):672-8. (PMID: 17067838)
Diabetes Obes Metab. 2019 Jul;21(7):1642-1651. (PMID: 30869182)
Am J Physiol Renal Physiol. 2013 Nov 15;305(10):F1466-76. (PMID: 23946291)
J Clin Epidemiol. 2014 Mar;67(3):267-77. (PMID: 24275499)
J Clin Lipidol. 2010 May-Jun;4(3):156-64. (PMID: 21122648)
JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):305-316. (PMID: 29055633)
Ann Rheum Dis. 2016 Sep;75(9):1674-9. (PMID: 26582823)
J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38. (PMID: 19942084)
N Engl J Med. 1999 Jan 14;340(2):115-26. (PMID: 9887164)
Clin Ther. 2019 Jan;41(1):30-40. (PMID: 30396516)
J Am Coll Cardiol. 2014 Mar 4;63(8):834-5. (PMID: 24315901)
Am J Ther. 2014 Nov-Dec;21(6):e189-95. (PMID: 22874645)
Eur Heart J. 2009 May;30(10):1180-6. (PMID: 19299430)
Nature. 2010 Apr 29;464(7293):1357-61. (PMID: 20428172)
N Engl J Med. 2017 Sep 21;377(12):1119-1131. (PMID: 28845751)
J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2889-934. (PMID: 24239923)
Lancet Diabetes Endocrinol. 2015 Apr;3(4):243-53. (PMID: 25726324)
Curr Rheumatol Rep. 2008 Jul;10(3):218-27. (PMID: 18638431)
Br Med J. 1977 Sep 24;2(6090):808. (PMID: 912334)
J Am Coll Cardiol. 2017 Oct 31;70(18):2278-2289. (PMID: 29073957)
N Engl J Med. 2019 Feb 21;380(8):752-762. (PMID: 30415610)
المشرفين على المادة: 0 (Biomarkers)
9007-41-4 (C-Reactive Protein)
SML2Y3J35T (Colchicine)
تواريخ الأحداث: Date Created: 20200901 Date Completed: 20201014 Latest Revision: 20201014
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7458326
DOI: 10.1371/journal.pone.0237665
PMID: 32866166
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0237665