دورية أكاديمية
Proton-pump-inhibitor use associated with lower short-term rebleeding and mortality in patients receiving esophageal variceal band ligation: a retrospective cohort study.
| العنوان: | Proton-pump-inhibitor use associated with lower short-term rebleeding and mortality in patients receiving esophageal variceal band ligation: a retrospective cohort study. |
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| المؤلفون: | Ghoz H; Division of Gastroenterology and Hepatology, Department of Medicine., Patel P; Division of Internal Medicine., Stancampiano F; Division of Internal Medicine., Patel S; Division of Internal Medicine., Fox EA; Clinical Research Internship Study Program (CRISP)., Yousaf MB; Clinical Research Internship Study Program (CRISP)., Omer M; Division of Infectious diseases, Clinical Studies Unit., Heckman MG; Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA., Spiegel MR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida, USA., Palmer WC; Division of Gastroenterology and Hepatology, Department of Medicine. |
| المصدر: | European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2020 Dec; Vol. 32 (12), pp. 1571-1578. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 9000874 Publication Model: Print Cited Medium: Internet ISSN: 1473-5687 (Electronic) Linking ISSN: 0954691X NLM ISO Abbreviation: Eur J Gastroenterol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Lippincott Williams And Wilkins Original Publication: [London, UK ; Philadelphia, PA, USA] : Current Science, c1989- |
| مواضيع طبية MeSH: | Esophageal and Gastric Varices*/etiology , Esophageal and Gastric Varices*/therapy , Portasystemic Shunt, Transjugular Intrahepatic*, Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Ligation ; Proton Pump Inhibitors/adverse effects ; Protons ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Background: The impact of proton-pump inhibitor (PPI) therapy on subsequent hemorrhage and mortality after variceal hemorrhage is unclear. Aim: Evaluate the associations of PPI use with upper gastrointestinal bleeding (UGIB) and death within 30 days of undergoing esophageal variceal band ligation (EBL) separately in inpatient and outpatient settings. Methods: Retrospective review of cirrhotic patients with variceal hemorrhage who underwent EBL between 2005 and 2018. Endoscopic findings, PPI use at admission (inpatients only), PPI use at discharge (inpatients and outpatients), and adverse outcomes data (liver transplant, UGIB, transjugular intrahepatic portosystemic shunt, and death within 30 days of discharge or death during hospitalization) were reviewed. Results: A total of 446 patients (164 inpatients, 282 outpatients) were included. The most commonly observed outcomes were death within 30 days of discharge in inpatients (12.8%), UGIB within 30 days of discharge in inpatients (21.3%), and UGIB within 30 days of discharge in outpatients (8.5%). For inpatients, prescription of PPI at discharge was associated with a lower risk of bleeding within 30 days (odds ratio: 0.30, P = 0.025) and death within 30 days (odds ratio = 0.16, P = 0.002). No other significant associations of PPI with death or UGIB were reported. Conclusion: Post-EBL PPI therapy is associated with reduced risk of bleeding and death within 30 days after variceal hemorrhage in hospitalized patients. |
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| المشرفين على المادة: | 0 (Proton Pump Inhibitors) 0 (Protons) |
| تواريخ الأحداث: | Date Created: 20200902 Date Completed: 20210728 Latest Revision: 20210728 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/MEG.0000000000001905 |
| PMID: | 32868651 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-5687 |
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| DOI: | 10.1097/MEG.0000000000001905 |