دورية أكاديمية
Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2.
| العنوان: | Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2. |
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| المؤلفون: | Shahinshavali S; Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India., Hossain KA; Department of Physical Chemistry, Gdansk University of Technology, Gdańsk, Poland., Kumar AVDN; Department of Chemistry, GIS, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, INDIA, 530045., Reddy AG; Department of Pharmacy, Sana College of Pharmacy, Kodad 508 206, Telangana, India., Kolli D; Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram 522502, Andhra Pradesh, India., Nakhi A; Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India., Rao MVB; Department of Chemistry, Krishna University, Machilipatnam 521001, Andhra Pradesh, India., Pal M; Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India. |
| المصدر: | Tetrahedron letters [Tetrahedron Lett] 2020 Oct 01; Vol. 61 (40), pp. 152336. Date of Electronic Publication: 2020 Aug 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 2984819R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0040-4039 (Print) Linking ISSN: 00404039 NLM ISO Abbreviation: Tetrahedron Lett Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Original Publication: Oxford, New York, Pergamon Press. |
| مستخلص: | In view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their binding affinities via docking into the N-terminal RNA-binding domain (NTD) of N-protein of SARS-CoV-2 prompted further study of these molecules. Thus building of a small library of molecules based on the said template became essential for this purpose. Accordingly, a convenient and environmentally safer method has been developed for the rapid synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives under Cu-catalysis assisted by ultrasound. This simple and straightforward method involved the coupling of 2,3-dichloroquinoxaline with commercially available terminal alkynes in the presence of CuI, PPh Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2020 Elsevier Ltd. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Alkyne; COVID-19; Chloroquinoxaline; In silico study; Ultrasound |
| تواريخ الأحداث: | Date Created: 20200902 Latest Revision: 20200919 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7449981 |
| DOI: | 10.1016/j.tetlet.2020.152336 |
| PMID: | 32868957 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0040-4039 |
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| DOI: | 10.1016/j.tetlet.2020.152336 |