دورية أكاديمية
Metabolic profiling reveals alterations in the erythrocyte response to fava bean ingestion in G6PD-deficient mice.
| العنوان: | Metabolic profiling reveals alterations in the erythrocyte response to fava bean ingestion in G6PD-deficient mice. |
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| المؤلفون: | Du G; Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China.; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, China., Xiao M; Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China., Chen B; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, China., Wang A; Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China., Zhu Q; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, China., Cai W; Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, China.; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, China. |
| المصدر: | Journal of the science of food and agriculture [J Sci Food Agric] 2021 Mar 15; Vol. 101 (4), pp. 1562-1571. Date of Electronic Publication: 2020 Sep 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons Original Publication: London, Society of Chemical Industry. |
| مواضيع طبية MeSH: | Erythrocytes/*metabolism , Favism/*metabolism , Glucosephosphate Dehydrogenase Deficiency/*metabolism , Vicia faba/*metabolism, Animals ; Erythrocytes/enzymology ; Fatty Acids, Unsaturated/metabolism ; Favism/enzymology ; Favism/genetics ; Glucosephosphate Dehydrogenase Deficiency/enzymology ; Glucosephosphate Dehydrogenase Deficiency/genetics ; Glycerophospholipids/metabolism ; Humans ; Male ; Metabolomics ; Mice ; Mice, Inbred C3H ; Mice, Knockout |
| مستخلص: | Background: Favism is an acute hemolytic syndrome caused by fava bean (FB) ingestion. The purpose of this study was to investigate the possible influences of FB on the metabonomic profile of erythrocytes in glucose-6-phosphate dehydrogenase (G6PD)-deficient (G6PDx) and wild-type (WT) mice. Results: Ninety-two metabolites were identified in the comparison of the G6PDx and WT groups. Eighty-seven metabolites were identified in the erythrocytes of WT and G6PDx mice after FB ingestion. Thirty-eight metabolites were identified in the comparison of the FB-treated G6PDx and the FB-treated WT mouse groups. Among them, the number of glycerophospholipids (GPLs) and polyunsaturated fatty acids (PUFAs) changed significantly, which suggests that GPLs and PUFAs may be responsible for FB stress. Conclusion: This study demonstrates that G6PD deficiency might affect the metabonomic profile of erythrocytes in response to FB. © 2020 Society of Chemical Industry. (© 2020 Society of Chemical Industry.) |
| References: | Luzzatto L and Favism AP, Glucose-6-phosphate dehydrogenase deficiency. N Engl J Med 378:1068-1069 (2018). Nkhoma ET, Poole C, Vannappagari V, Hall SA and Beutler E, The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 42:267-278 (2009). Luzzatto L and Favism AP, Glucose-6-phosphate dehydrogenase deficiency. N Engl J Med 378:60-71 (2018). Yang HC, Wu YH, Yen WC, Liu HY, Hwang TL, Stern A et al., The redox role of G6PD in cell growth, cell death, and cancer. Cells 8:1055 (2019). Tang BL, Neuroprotection by glucose-6-phosphate dehydrogenase and the pentose phosphate pathway. J Cell Biochem 120:14285-14295 (2019). Zam W and Belal L, Ex vivo study of Laban's role in decreasing hemolysis crisis in G6PD-deficient patients. J Nutri Metab 2020:8034672 (2020). Multari S, Stewart D and Russell WR, Potential of fava bean as future protein supply to partially replace meat intake in the human diet. Comprehen Rev Food Sci Food Saf 14:511-522 (2015). McMillan DC, Bolchoz LJ and Jollow DJ, Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins. Toxicol Sci 62:353-359 (2001). McMillan DC, Schey KL, Meier GP and Jollow DJ, Chemical analysis and hemolytic activity of the fava bean aglycon divicine. Chem Res Toxicol 6:439-444 (1993). Fornaini G, Leoncini G, Luzzatto L and Segni G, Glucose metabolism in human erythrocytes from normal and fava bean-sensitive subjects. J Clin Invest 41:1446-1453 (1962). Turrini F, Naitana A, Mannuzzu L, Pescarmona G and Arese P, Increased red cell calcium, decreased calcium adenosine triphosphatase, and altered membrane proteins during fava bean hemolysis in glucose-6-phosphate dehydrogenase-deficient (Mediterranean variant) individuals. Blood 66:302-305 (1985). van Wijk R and van Solinge WW, The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis. Blood 106:4034-4042 (2005). Holz GG Jr, Lipids and the malarial parasite. Bull World Health Organ 55:237 (1977). Reed CF, Phospholipid exchange between plasma and erythrocytes in man and the dog. J Clin Investig 47:749-760 (1968). Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL et al., Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Investig 101:1458-1467 (1998). Sengupta A and Ghosh M, Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. J Oleo Sci 63:439-447 (2014). Van Deenen L and De Gier J, Lipids of the red cell membrane. Red Blood Cell 1:147-211 (1974). Sleep J, Wilson D, Simmons R and Gratzer W, Elasticity of the red cell membrane and its relation to hemolytic disorders: an optical tweezers study. Biophys J 77:3085-3095 (1999). Valentine WN, Tanaka KR and Paglia DE, Hemolytic anemias and erythrocyte enzymopathies. Ann Intern Med 103:245-257 (1985). Ziboh VA, Dreize M and Hsia S, Inhibition of lipid synthesis and glucose-6-phosphate dehydrogenase in rat skin by dehydroepiandrosterone. J Lipid Res 11:346-354 (1970). Xiao M, Du G, Zhong G, Yan D, Zeng H and Cai W, Gas chromatography/mass spectrometry-based Metabolomic profiling reveals alterations in mouse plasma and liver in response to fava beans. PloS One 11:e0151103 (2016). Bird SS, Marur VR, Sniatynski MJ, Greenberg HK, Kristal BS. Lipidomics profiling by high-resolution LC-MS and high-energy collisional dissociation fragmentation: focus on characterization of mitochondrial cardiolipins and monolysocardiolipins. Analytical Chemistry 83:940-949 (2011). Luzzatto L, Ally M and Notaro R, Glucose-6-phosphate dehydrogenase deficiency. Blood (2020). published online ahead of print. Xia J, Sinelnikov IV, Han B and Wishart DS, MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Res 43:W251-W257 (2015). McMillan DC and Jollow DJ, Favism: divicine hemotoxicity in the rat. Toxicol Sci 51:310-316 (1999). D'Aquino M, Gaetani S and Spadoni MA, Effect of factors of favism on the protein and lipid components of rat erythrocyte membrane. Biochim Biophys Acta 731:161-167 (1983). Du G, Xiao M, Wei X, Zhou C, Li S and Cai W, Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice. Gene 652:66-77 (2018). Farooqui AA, Horrocks LA and Farooqui T, Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem Phys Lipids 106:1-29 (2000). Han X and Gross RW, Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc Natl Acad Sci U S A 91:10635-10639 (1994). Hermansson M, Hokynar K and Somerharju P, Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog Lipid Res 50:240-257 (2011). Jacob HS, Membrane lipid depletion in hyperpermeable red blood cells: its role in the genesis of spherocytes in hereditary spherocytosis. J Clin Invest 46:2083-2094 (1967). Marzouki ZM and Khoja SM, Plasma and red blood cells membrane lipid concentration of sickle cell disease patients. Saudi Med J 24:376-379 (2003). Sugihara T, Otsuka A and Yawata Y, Contribution of the spleen to the lipid metabolism in plasma and red cells. On hereditary spherocytosis and hereditary high red cell membrane phosphatidylcholine hemolytic anemia. Japan J Clin Hematol 30:1248-1255 (1989). Tamai H, Miki M and Mino M, Hemolysis and membrane lipid changes induced by xanthine oxidase in vitamin E deficient red cells. J Free Radic Biol Med 2:49-56 (1986). Lyles DS and Landsberger FR, Sendai virus-induced hemolysis: reduction in heterogeneity of erythrocyte lipid bilayer fluidity. Proc Natl Acad Sci U S A 74:1918-1922 (1977). Chen T, Yang HC, Hung CY, Ou MH, Pan YY, Cheng ML, Stern A, Lo SJ, Daniel Tsun Yee C et al., Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Cell Death Dis 8:e2545 (2018). Wiktorowska-Owczarek A, Berezińska M and Nowak JZ, PUFAs: structures, metabolism and functions. Adv Clin Exp Med 24:931-941 (2015). Losano JDA, Angrimani DSR, Dalmazzo A, Rocha CC, Brito MM, Perez EGA et al., Effect of vitamin E and polyunsaturated fatty acids on cryopreserved sperm quality in Bos taurus bulls under testicular heat stress. Anim Biotechnol 29:100-109 (2018). Galvan I, Evidence of evolutionary optimization of fatty acid length and unsaturation. J Evol Biol 31:172-176 (2018). Clemens MR, Einsele H and Waller HD, The fatty acid composition of red cells deficient in glucose-6-phosphate dehydrogenase and their susceptibility to lipid peroxidation. Klin Wochenschr 63:578-582 (1985). Gossai D and Lau-Cam CA, The effects of taurine, hypotaurine, and taurine homologs on erythrocyte morphology, membrane fluidity and cytoskeletal spectrin alterations due to diabetes, alcoholism and diabetes-alcoholism in the rat. Adv Exp Med Biol 643:369-379 (2009). Khot V, Chavan-Gautam P and Joshi S, Proposing interactions between maternal phospholipids and the one carbon cycle: a novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life. Life Sci 129:16-21 (2015). Murphy MM and Gueant JL, B vitamins and one carbon metabolism micronutrients in health and disease. Biochimie 173:1-2 (2020). Steele JW, Kim SE and Finnell RH, One-carbon metabolism and folate transporter genes: do they factor prominently in the genetic etiology of neural tube defects? Biochimie 173:27-32 (2020). Das U, Folic acid says NO to vascular diseases. Nutrition 19:686-692 (2003). Cabrini L, Bochicchio D, Bordoni A, Sassi S and Maranesi M, Correlation between dietary polyunsaturated fatty acids and plasma homocysteine concentration in vitamin B6-deficient rats. Nutri Metab Cardiovasc Dis 15:94-99 (2005). |
| معلومات مُعتمدة: | 2012CB526600 National Key Basic Research Program of China; 81260092 National Natural Science Foundation of China; 81641010 National Natural Science Foundation of China; 30960171 National Natural Science Foundation of China |
| فهرسة مساهمة: | Keywords: Favism; G6PD; erythrocytes; fava beans; membrane; metabonomic profile |
| المشرفين على المادة: | 0 (Fatty Acids, Unsaturated) 0 (Glycerophospholipids) |
| تواريخ الأحداث: | Date Created: 20200902 Date Completed: 20210402 Latest Revision: 20210402 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jsfa.10775 |
| PMID: | 32869306 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0010 |
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| DOI: | 10.1002/jsfa.10775 |