دورية أكاديمية
Application of microfluidic devices for glioblastoma study: current status and future directions.
| العنوان: | Application of microfluidic devices for glioblastoma study: current status and future directions. |
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| المؤلفون: | Cai X; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Briggs RG; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Homburg HB; Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Young IM; Cingulum Health, Sydney, Australia., Davis EJ; Cingulum Health, Sydney, Australia., Lin YH; Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Sydney, Australia., Battiste JD; Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA., Sughrue ME; Cingulum Health, Sydney, Australia. sughruevs@gmail.com.; Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, Suite 19, Level 7, Barker Street, Randwick, New South Wales, 2031, Australia. sughruevs@gmail.com. |
| المصدر: | Biomedical microdevices [Biomed Microdevices] 2020 Sep 01; Vol. 22 (3), pp. 60. Date of Electronic Publication: 2020 Sep 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer US Country of Publication: United States NLM ID: 100887374 Publication Model: Electronic Cited Medium: Internet ISSN: 1572-8781 (Electronic) Linking ISSN: 13872176 NLM ISO Abbreviation: Biomed Microdevices |
| أسماء مطبوعة: | Publication: New York : Springer US Original Publication: Boston : Kluwer Academic Publishers, 1998- |
| مواضيع طبية MeSH: | Glioblastoma*/pathology , Glioblastoma*/metabolism , Lab-On-A-Chip Devices* , Brain Neoplasms*/pathology , Brain Neoplasms*/therapy, Humans ; Tumor Microenvironment ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/metabolism ; Animals |
| مستخلص: | Glioblastoma (GBM) is one of the most malignant primary brain tumors. This neoplasm is the hardest to treat and has a bad prognosis. Because of the characteristics of genetic heterogeneity and frequent recurrence, a successful cure for the disease is unlikely. Increasing evidence has revealed that the GBM stem cell-like cells (GSCs) and microenvironment are key elements in GBM recurrence and treatment failure. To better understand the mechanisms underlying this disease and to develop more effective therapeutic strategies for treatment, suitable approaches, techniques, and model systems closely mimicking real GBM conditions are required. Microfluidic devices, a model system mimicking the in vivo brain microenvironment, provide a very useful tool to analyze GBM cell behavior, their correlation with tumor malignancy, and the efficacy of multiple drug treatment. This paper reviews the applications of microfluidic devices in GBM research and summarizes progress and perspectives in this field. |
| معلومات مُعتمدة: | P20 GM103639 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Cell migration; Glioblastoma; Microenvironment; Microfluidic device; Single cells |
| تواريخ الأحداث: | Date Created: 20200902 Date Completed: 20240724 Latest Revision: 20240724 |
| رمز التحديث: | 20240726 |
| DOI: | 10.1007/s10544-020-00516-1 |
| PMID: | 32870410 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1572-8781 |
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| DOI: | 10.1007/s10544-020-00516-1 |