دورية أكاديمية
Mammalian stress granules and P bodies at a glance.
| العنوان: | Mammalian stress granules and P bodies at a glance. |
|---|---|
| المؤلفون: | Riggs CL; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA., Kedersha N; Brigham and Woman's Hospital/Harvard Medical School, Harvard University, Boston, MA 02115, USA., Ivanov P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA pivanov@rics.bwh.harvard.edu panderson@bwh.harvard.edu., Anderson P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA pivanov@rics.bwh.harvard.edu panderson@bwh.harvard.edu. |
| المصدر: | Journal of cell science [J Cell Sci] 2020 Sep 01; Vol. 133 (16). Date of Electronic Publication: 2020 Sep 01. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Company of Biologists Original Publication: London. |
| مواضيع طبية MeSH: | Cytoplasmic Granules* , Organelles*, Animals ; Mammals ; RNA Stability ; RNA, Messenger/genetics ; Ribonucleoproteins/genetics ; Stress, Physiological |
| مستخلص: | Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and PBs form through liquid-liquid phase separation that is driven by high local concentrations of key proteins and RNAs, both of which dynamically shuttle between the granules and the cytoplasm. SGs uniquely contain certain translation initiation factors and PBs are uniquely enriched with factors related to mRNA degradation and decay, although recent analyses reveal much broader protein commonality between these granules. Despite detailed knowledge of their composition and dynamics, the function of SGs and PBs remains poorly understood. Both, however, contain mRNAs, implicating their assembly in the regulation of RNA metabolism. SGs may also serve as hubs that rewire signaling events during stress. By contrast, PBs may constitute RNA storage centers, independent of mRNA decay. The aberrant assembly or disassembly of these granules has pathological implications in cancer, viral infection and neurodegeneration. Here, we review the current concepts regarding the formation, composition, dynamics, function and involvement in disease of SGs and PBs. (© 2020. Published by The Company of Biologists Ltd.) |
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| معلومات مُعتمدة: | R01 GM126150 United States GM NIGMS NIH HHS; R35 GM126901 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Cell stress; P bodies; Protein synthesis; RNA metabolism; Stress Granules |
| المشرفين على المادة: | 0 (RNA, Messenger) 0 (Ribonucleoproteins) |
| تواريخ الأحداث: | Date Created: 20200903 Date Completed: 20210618 Latest Revision: 20231129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10679417 |
| DOI: | 10.1242/jcs.242487 |
| PMID: | 32873715 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1477-9137 |
|---|---|
| DOI: | 10.1242/jcs.242487 |