دورية أكاديمية
Mammalian stress granules and P bodies at a glance.
العنوان: | Mammalian stress granules and P bodies at a glance. |
---|---|
المؤلفون: | Riggs CL; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA., Kedersha N; Brigham and Woman's Hospital/Harvard Medical School, Harvard University, Boston, MA 02115, USA., Ivanov P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA pivanov@rics.bwh.harvard.edu panderson@bwh.harvard.edu., Anderson P; Division of Rheumatology, Immunity, and Inflammation, Brigham and Women's Hospital, Harvard University, Boston, MA 02115, USA pivanov@rics.bwh.harvard.edu panderson@bwh.harvard.edu. |
المصدر: | Journal of cell science [J Cell Sci] 2020 Sep 01; Vol. 133 (16). Date of Electronic Publication: 2020 Sep 01. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge : Company of Biologists Original Publication: London. |
مواضيع طبية MeSH: | Cytoplasmic Granules* , Organelles*, Animals ; Mammals ; RNA Stability ; RNA, Messenger/genetics ; Ribonucleoproteins/genetics ; Stress, Physiological |
مستخلص: | Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-based cellular compartments that assemble in response to stress. SGs and PBs form through liquid-liquid phase separation that is driven by high local concentrations of key proteins and RNAs, both of which dynamically shuttle between the granules and the cytoplasm. SGs uniquely contain certain translation initiation factors and PBs are uniquely enriched with factors related to mRNA degradation and decay, although recent analyses reveal much broader protein commonality between these granules. Despite detailed knowledge of their composition and dynamics, the function of SGs and PBs remains poorly understood. Both, however, contain mRNAs, implicating their assembly in the regulation of RNA metabolism. SGs may also serve as hubs that rewire signaling events during stress. By contrast, PBs may constitute RNA storage centers, independent of mRNA decay. The aberrant assembly or disassembly of these granules has pathological implications in cancer, viral infection and neurodegeneration. Here, we review the current concepts regarding the formation, composition, dynamics, function and involvement in disease of SGs and PBs. (© 2020. Published by The Company of Biologists Ltd.) |
References: | J Cell Biol. 2003 Mar 17;160(6):823-31. (PMID: 12642610) Cell. 2015 Sep 24;163(1):123-33. (PMID: 26406374) J Gen Virol. 2019 Oct;100(10):1375-1389. (PMID: 31418676) Cell Res. 2019 Mar;29(3):233-247. (PMID: 30728452) Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):2734-2739. (PMID: 29483269) J Clin Invest. 2008 Jul;118(7):2651-60. (PMID: 18551192) J Cell Biol. 1997 Feb 24;136(4):761-73. (PMID: 9049243) J Cell Biol. 1999 Dec 27;147(7):1431-42. (PMID: 10613902) Virology. 2013 Feb 5;436(1):1-7. (PMID: 23102969) Mol Biol Cell. 2009 May;20(9):2464-72. (PMID: 19297524) PLoS One. 2014 Nov 19;9(11):e112742. (PMID: 25409157) Mol Biol Cell. 2015 Jul 15;26(14):2579-95. (PMID: 25995375) Cell Death Dis. 2018 Nov 13;9(11):1129. (PMID: 30425239) Mol Cell. 2017 Nov 16;68(4):808-820.e5. (PMID: 29129640) J Biol Chem. 2005 Apr 29;280(17):16925-33. (PMID: 15684421) Mol Biol Cell. 2009 Jan;20(1):428-37. (PMID: 19005212) Nat Cell Biol. 2008 Oct;10(10):1224-31. (PMID: 18794846) RNA. 2005 May;11(5):717-27. (PMID: 15840819) Am J Hum Genet. 2019 Sep 5;105(3):509-525. (PMID: 31422817) Mol Cancer Ther. 2009 May;8(5):1250-60. (PMID: 19417157) Mol Biol Cell. 2008 Oct;19(10):4469-79. (PMID: 18632980) EMBO J. 2007 Dec 12;26(24):5020-32. (PMID: 18034160) Clin Cancer Res. 2009 Sep 1;15(17):5414-25. (PMID: 19690198) J Cell Sci. 2016 Jun 15;129(12):2407-15. (PMID: 27160682) Annu Rev Cell Dev Biol. 1998;14:399-458. (PMID: 9891789) Nat Cell Biol. 2005 Jul;7(7):719-23. (PMID: 15937477) J Virol. 2010 Dec;84(23):12274-84. (PMID: 20844027) Mol Biol Cell. 2006 Mar;17(3):1388-98. (PMID: 16407409) Cell. 2016 Apr 7;165(2):488-96. (PMID: 26997482) RNA Biol. 2014;11(8):1019-30. (PMID: 25531407) Mol Cell Biol. 2004 Dec;24(24):10718-32. (PMID: 15572676) Exp Mol Med. 2019 Apr 26;51(4):1-12. (PMID: 31028247) Cell. 2016 Jan 28;164(3):487-98. (PMID: 26777405) Immunity. 2000 Jul;13(1):129-41. (PMID: 10933401) Annu Rev Virol. 2014 Nov;1(1):147-70. (PMID: 26958719) J Cell Biol. 2004 Apr;165(1):31-40. (PMID: 15067023) Nat Commun. 2016 Jul 06;7:12125. (PMID: 27381497) J Cell Biol. 2016 Nov 7;215(3):313-323. (PMID: 27821493) Nucleic Acids Res. 2017 Jun 20;45(11):6911-6922. (PMID: 28472520) J Biol Chem. 2010 Apr 2;285(14):10959-68. (PMID: 20129916) Mol Cell Biol. 2006 Dec;26(23):8803-13. (PMID: 16982678) Trends Biochem Sci. 2013 Oct;38(10):494-506. (PMID: 24029419) Mol Cell. 2018 Feb 1;69(3):517-532.e11. (PMID: 29395067) EMBO J. 2004 Mar 24;23(6):1313-24. (PMID: 15014438) Mol Biol Cell. 2012 Dec;23(24):4701-12. (PMID: 23087212) J Cell Biol. 2006 Nov 20;175(4):527-34. (PMID: 17101699) Mol Cell Biol. 2007 Sep;27(18):6469-83. (PMID: 17562864) Mol Biol Cell. 2004 Dec;15(12):5383-98. (PMID: 15371533) Adv Exp Med Biol. 2013;768:197-211. (PMID: 23224972) Neuron. 2008 Oct 23;60(2):201-14. (PMID: 18957214) J Cell Biol. 2016 Sep 12;214(6):769-81. (PMID: 27597760) Cold Spring Harb Perspect Biol. 2019 May 1;11(5):. (PMID: 30082464) Mol Cell. 2007 Mar 9;25(5):765-78. (PMID: 17349961) Cell. 2018 Jan 25;172(3):590-604.e13. (PMID: 29373831) Cell. 2006 Jun 16;125(6):1111-24. (PMID: 16777601) Biochem Soc Trans. 2002 Nov;30(Pt 6):963-9. (PMID: 12440955) J Biol Chem. 1998 Jan 23;273(4):2416-23. (PMID: 9442091) Science. 2017 Sep 22;357(6357):. (PMID: 28935776) Nat Rev Neurosci. 2019 Nov;20(11):649-666. (PMID: 31582840) Mol Cell Biol. 2019 Nov 25;39(24):. (PMID: 31591142) Cell. 2009 Feb 20;136(4):731-45. (PMID: 19239892) Mol Cell. 2011 Aug 19;43(4):613-23. (PMID: 21855800) Cell Host Microbe. 2007 Nov 15;2(5):295-305. (PMID: 18005751) Wiley Interdiscip Rev RNA. 2019 May;10(3):e1524. (PMID: 30793528) Mol Cell Biol. 1995 Aug;15(8):4497-506. (PMID: 7623840) Mol Cell. 2015 Oct 15;60(2):208-19. (PMID: 26412307) Curr Opin Struct Biol. 2017 Jun;44:18-30. (PMID: 27838525) Cold Spring Harb Symp Quant Biol. 2006;71:29-38. (PMID: 17381277) Science. 2003 May 2;300(5620):805-8. (PMID: 12730603) Elife. 2019 Dec 19;8:. (PMID: 31855182) Mol Cell. 2017 Nov 2;68(3):615-625.e9. (PMID: 29056324) Mol Biol Cell. 2002 Jan;13(1):195-210. (PMID: 11809833) FASEB J. 2012 Apr;26(4):1629-39. (PMID: 22202676) Nat Cell Biol. 2008 Nov;10(11):1324-32. (PMID: 18836437) Cell. 2020 Apr 16;181(2):306-324.e28. (PMID: 32302570) Cell. 2012 May 11;149(4):753-67. (PMID: 22579281) Biochem Pharmacol. 2011 Mar 15;81(6):713-22. (PMID: 21219881) Clin Immunol. 2007 Dec;125(3):247-56. (PMID: 17870671) Brain Res. 2014 Oct 10;1584:52-8. (PMID: 25108040) Trends Cell Biol. 2014 Aug;24(8):472-8. (PMID: 24985940) J Cell Biol. 2016 Mar 28;212(7):845-60. (PMID: 27022092) Cell Death Differ. 2020 Jan;27(1):227-241. (PMID: 31114027) PLoS One. 2010 Oct 11;5(10):e13250. (PMID: 20948999) J Biol Chem. 2012 Jan 20;287(4):2446-58. (PMID: 22147700) Biochim Biophys Acta. 2015 Jul;1849(7):861-70. (PMID: 25482014) Cancer Cell. 2004 May;5(5):429-41. (PMID: 15144951) Biochem Biophys Res Commun. 2012 Jul 13;423(4):763-9. (PMID: 22705549) J Cell Sci. 2009 Oct 15;122(Pt 20):3619-26. (PMID: 19812307) Mol Cell. 2019 May 2;74(3):521-533.e6. (PMID: 30952514) J Neurosci. 2012 Jun 13;32(24):8270-83. (PMID: 22699908) J Virol. 2007 Mar;81(5):2165-78. (PMID: 17166910) Mol Cell Biol. 2012 Nov;32(22):4572-84. (PMID: 22966201) Cell Stem Cell. 2019 Nov 7;25(5):622-638.e13. (PMID: 31588046) J Cell Biol. 2005 Jun 20;169(6):871-84. (PMID: 15967811) J Biol Chem. 2006 Oct 27;281(43):32870-8. (PMID: 16951406) Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3073-8. (PMID: 10737787) Nucleic Acids Res. 2015 Feb 27;43(4):e26. (PMID: 25488811) Nature. 2016 Nov 10;539(7628):197-206. (PMID: 27830784) Trends Biochem Sci. 2008 Mar;33(3):141-50. (PMID: 18291657) Nat Cell Biol. 2005 Jun;7(6):633-6. (PMID: 15908945) Cell Host Microbe. 2012 Jun 14;11(6):563-75. (PMID: 22704617) J Cell Sci. 2005 Mar 1;118(Pt 5):981-92. (PMID: 15731006) Methods Enzymol. 2007;431:61-81. (PMID: 17923231) Proc Natl Acad Sci U S A. 2007 May 22;104(21):9041-6. (PMID: 17502609) PLoS One. 2011 Mar 01;6(3):e17296. (PMID: 21390246) Genes Dev. 2007 Dec 15;21(24):3381-94. (PMID: 18079183) Neuron. 2017 Aug 16;95(4):808-816.e9. (PMID: 28817800) Nucleic Acids Res. 2012 Sep;40(16):8099-110. (PMID: 22718973) J Biol Chem. 2016 Oct 21;291(43):22671-22685. (PMID: 27601476) Mol Cell Biol. 2007 Mar;27(6):2324-42. (PMID: 17210633) Hum Mol Genet. 2002 Nov 15;11(24):3007-17. (PMID: 12417522) Science. 2005 Oct 21;310(5747):486-9. (PMID: 16141371) Bioessays. 2019 May;41(5):e1900009. (PMID: 31026340) Methods Enzymol. 2008;448:521-52. (PMID: 19111193) Mol Biol Cell. 2005 Aug;16(8):3753-63. (PMID: 15930128) Wiley Interdiscip Rev RNA. 2013 May-Jun;4(3):317-31. (PMID: 23554219) Arthritis Res Ther. 2016 Jan 22;18:27. (PMID: 26801089) J Cell Biol. 2005 Sep 12;170(6):913-24. (PMID: 16157702) Cell. 2016 Jun 16;165(7):1686-1697. (PMID: 27212236) Mol Cell. 2017 Oct 5;68(1):144-157.e5. (PMID: 28965817) Mol Cell. 2000 May;5(5):897-904. (PMID: 10882126) J Cell Biol. 2015 Mar 30;208(7):913-29. (PMID: 25800057) Mol Cell Biol. 2007 Jun;27(11):3970-81. (PMID: 17403906) Genes Dev. 2013 Dec 15;27(24):2628-41. (PMID: 24352420) J Cell Biol. 2000 Dec 11;151(6):1257-68. (PMID: 11121440) J Cell Biol. 2011 Aug 22;194(4):581-96. (PMID: 21859862) RNA Biol. 2012 May;9(5):610-23. (PMID: 22614839) |
معلومات مُعتمدة: | R01 GM126150 United States GM NIGMS NIH HHS; R35 GM126901 United States GM NIGMS NIH HHS |
فهرسة مساهمة: | Keywords: Cell stress; P bodies; Protein synthesis; RNA metabolism; Stress Granules |
المشرفين على المادة: | 0 (RNA, Messenger) 0 (Ribonucleoproteins) |
تواريخ الأحداث: | Date Created: 20200903 Date Completed: 20210618 Latest Revision: 20231129 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10679417 |
DOI: | 10.1242/jcs.242487 |
PMID: | 32873715 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1477-9137 |
---|---|
DOI: | 10.1242/jcs.242487 |