دورية أكاديمية
Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management.
| العنوان: | Gastro-entero-pancreatic neuroendocrine neoplasia: The rules for non-operative management. |
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| المؤلفون: | Panzuto F; Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy. Electronic address: fpanzuto@ospedalesantandrea.it., Massironi S; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Partelli S; Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute - Vita-Salute San Raffaele University, Milan, Italy., Campana D; Division of Oncology, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Rinzivillo M; Digestive Disease Unit, Sant'Andrea University Hospital, ENETS Center of Excellence, Rome, Italy., Invernizzi P; Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Andreasi V; Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute - Vita-Salute San Raffaele University, Milan, Italy., Lamberti G; Division of Oncology, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Falconi M; Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, ENETS Center of Excellence, IRCCS San Raffaele Scientific Institute - Vita-Salute San Raffaele University, Milan, Italy. |
| المصدر: | Surgical oncology [Surg Oncol] 2020 Dec; Vol. 35, pp. 141-148. Date of Electronic Publication: 2020 Aug 20. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9208188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3320 (Electronic) Linking ISSN: 09607404 NLM ISO Abbreviation: Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Oxford ; Boston : Blackwell Scientific Publications, c1992- |
| مواضيع طبية MeSH: | Endoscopy/*methods , Intestinal Neoplasms/*therapy , Neuroendocrine Tumors/*therapy , Pancreatic Neoplasms/*therapy , Stomach Neoplasms/*therapy, Disease Management ; Humans ; Intestinal Neoplasms/pathology ; Neuroendocrine Tumors/pathology ; Pancreatic Neoplasms/pathology ; Prognosis ; Stomach Neoplasms/pathology |
| مستخلص: | Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) with favorable pathological and clinical features may be considered as indolent lesions, and therefore be amenable to conservative management. According to the primary tumor site, different non-aggressive approaches, based on endoscopic resection or simple active surveillance, can be proposed to selected patients fulfilling specific criteria. Tumor size, Ki67 proliferative index and depth of invasion are markers that can be used in order to identify these subjects. Patients with type I gastric NENs <1 cm as well as those with non-ampullary duodenal NENs <1 cm with no associated syndrome can be safely managed by endoscopic resection. On the other hand, an active surveillance approach is preferred over surgery for patients with asymptomatic, non-functioning pancreatic NENs ≤2 cm without dilation of the main pancreatic duct or bile duct. As far as NENs of the appendix are concerned, appendectomy should be considered as curative when a R0 resection has been achieved in the presence of a tumor ≤1.5 cm, graded as G1 and without lymphovascular invasion. Finally, G1 rectal NENs ≤1 cm without invasion of the muscular layer can be safely treated by endoscopic resection. Therefore, surgeons should be aware of the existence of indolent GEP-NENs, in order to avoid unnecessary operations with associated postoperative complications. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Active surveillance; Carcinoids; Endoscopic resection; Follow-up; Indolent; Neuroendocrine neoplasms; Surgery |
| SCR Disease Name: | Gastro-enteropancreatic neuroendocrine tumor |
| تواريخ الأحداث: | Date Created: 20200903 Date Completed: 20211008 Latest Revision: 20211008 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.suronc.2020.08.015 |
| PMID: | 32877883 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-3320 |
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| DOI: | 10.1016/j.suronc.2020.08.015 |