دورية أكاديمية
Differences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma.
| العنوان: | Differences in PET/CT standardized uptake values involvement and survival compared to histologic subtypes of lung adenocarcinoma. |
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| المؤلفون: | Ercelep O; Department of Medical Oncology, Pendik Education and Research Hospital, Marmara University, Istanbul, Turkey., Alan O; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Telli TA; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Tuylu TB; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Arıkan R; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Demircan NC; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Simsek ET; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Babacan NA; Department of Medical Oncology, Pendik Education and Research Hospital, Marmara University, Istanbul, Turkey., Kaya S; Department of Medical Oncology, Pendik Education and Research Hospital, Marmara University, Istanbul, Turkey., Dane F; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Bozkurtlar E; Department of Pathology, Faculty of Medicine, Marmara University, Istanbul, Turkey., Ones T; Department of Nuclear Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey., Lacin T; Department of Thoracic Surgery, Faculty of Medicine, Marmara University, Istanbul, Turkey., Yumuk PF; Department of Medical Oncology, Faculty of Medicine, Marmara University, Istanbul, Turkey. |
| المصدر: | Tumori [Tumori] 2021 Jun; Vol. 107 (3), pp. 231-237. Date of Electronic Publication: 2020 Sep 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 0111356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2038-2529 (Electronic) Linking ISSN: 03008916 NLM ISO Abbreviation: Tumori Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Thousand Oaks, CA : Sage Publications Original Publication: Milano : Istituto nazionale per lo studio e la cura dei tumori |
| مواضيع طبية MeSH: | Adenocarcinoma of Lung/*pathology , Lung Neoplasms/*pathology , Positron Emission Tomography Computed Tomography/*standards, Adult ; Aged ; Female ; Fluorodeoxyglucose F18/administration & dosage ; Humans ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography/methods ; Progression-Free Survival ; Radiopharmaceuticals/administration & dosage ; Retrospective Studies |
| مستخلص: | Purpose: Lung adenocarcinoma is histologically diverse but has distinct histologic growth patterns. There is no consensus on the clinical benefit of this histologic model. We aimed to evaluate the differences in the distribution of the preoperative primary tumor positron emission tomography (PET)/computed tomography (CT) standardized uptake values (SUVs) and survival in the lung adenocarcinoma subtypes. Methods: We retrospectively evaluated the data of 107 patients with resected lung adenocarcinoma who had preoperative PET/CT between 2005 and 2017 in a single center. Patients had lepidic, acinar, papillary, micropapillary, and solid histologic subtypes. We compared fluorodeoxyglucose SUVs and survival data of histologic subtypes. Results: The median age of the patients was 62 years (40-75), 76.4% were male, the median SUVmax was 9.4 (1-36.7), and the median follow-up time was 29 months (3-135 months). The median overall survival (OS) was 71 months and the median progression-free survival (PFS) was 33 months. SUVmax was significantly different in histologic subtypes: values for papillary, micropapillary, solid, acinar, and lepidic subtypes were 9.7, 8, 12, 9.1, and 3.9, respectively ( p = 0.000). Solid predominant adenocarcinoma had significantly higher SUVmax than the other subtypes ( p = 0.001). Lepidic predominant adenocarcinoma had significantly lower SUVmax than the other subtypes ( p = 0.000). There was no significant difference in OS between histologic subtypes ( p = 0.66), but PFS was significantly different between the groups ( p = 0.017), and the solid subtype had a shorter PFS than the other histologic subtypes. Conclusion: Lung adenocarcinoma consists of a diverse group of diseases. Different SUVmax values are seen in different histologic subtypes of nonmetastatic lung adenocarcinoma. Solid predominant types have high SUVmax values while lepidic predominant types have lower SUVmax values. The solid subtype had a shorter PFS than the other histologic subtypes. |
| فهرسة مساهمة: | Keywords: FDG/PET; Lung adenocarcinoma; SUVmax; histologic subtypes |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| تواريخ الأحداث: | Date Created: 20200904 Date Completed: 20210521 Latest Revision: 20220423 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/0300891620950475 |
| PMID: | 32878562 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2038-2529 |
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| DOI: | 10.1177/0300891620950475 |