التفاصيل البيبلوغرافية
| العنوان: |
Colloidal Stability and Redispersibility of Mesoporous Silica Nanoparticles in Biological Media. |
| المؤلفون: |
Schneid ADC, Silveira CP, Galdino FE; Instituto de Quı́mica (IQ), Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6154, CEP 13083-970 Campinas, São Paulo, Brasil., Ferreira LF; Pós Graduação em Biotecnociência, Universidade Federal do ABC, CEP 09210-580 Santo André, Brasil., Bouchmella K; Institut Charles Gerhardt Montpellier, UMR-5253 Univ Montpellier, CNRS, ENSCM, cc 1701, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France., Cardoso MB; Instituto de Quı́mica (IQ), Universidade Estadual de Campinas (UNICAMP), Caixa Postal 6154, CEP 13083-970 Campinas, São Paulo, Brasil.; Pós Graduação em Biotecnociência, Universidade Federal do ABC, CEP 09210-580 Santo André, Brasil. |
| المصدر: |
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2020 Oct 06; Vol. 36 (39), pp. 11442-11449. Date of Electronic Publication: 2020 Sep 22. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Chemical Society Country of Publication: United States NLM ID: 9882736 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5827 (Electronic) Linking ISSN: 07437463 NLM ISO Abbreviation: Langmuir Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington, DC : American Chemical Society, c1985- |
| مستخلص: |
The outreach of nanoparticle-based medical treatments has been severely hampered due to the imbalance between the efforts in designing extremely complex materials and the general lack of studies devoted to understanding their colloidal stability in biological environments. Over the years, the scientific community has neglected the relevance related to the nanoparticles' colloidal state, which consequently resulted in very poor bench-to-clinic translation. In this work, we show how mesoporous silica nanoparticles (MSNs, one of the most promising and tested drug delivery platforms) can be efficiently synthesized and prepared, resulting in a colloidally stable system. We first compared three distinct methods of template removal of MSNs and evaluated their ultimate colloidal stability. Then, we also proposed a simple way to prevent aggregation during the drying step by adsorbing BSA onto MSNs. The surface modification resulted in colloidally stable particles that are successfully redispersed in biologically relevant medium while retaining high hemocompatibility and low cytotoxicity. |
| تواريخ الأحداث: |
Date Created: 20200904 Date Completed: 20201020 Latest Revision: 20201020 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1021/acs.langmuir.0c01571 |
| PMID: |
32880180 |
| قاعدة البيانات: |
MEDLINE |
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