دورية أكاديمية
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Distinct Effects of Milk-Derived and Fermented Dairy Protein on Gut Microbiota and Cardiometabolic Markers in Diet-Induced Obese Mice.

التفاصيل البيبلوغرافية
العنوان: Distinct Effects of Milk-Derived and Fermented Dairy Protein on Gut Microbiota and Cardiometabolic Markers in Diet-Induced Obese Mice.
المؤلفون: Perazza LR; Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Daniel N; Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Dubois MJ; Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Pilon G; Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Varin TV; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Blais M; Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada., Martinez Gonzales JL; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Bouchard M; Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada., Asselin C; Faculty of Medicine and Health Sciences, Sherbrooke University, Sherbrooke, Quebec, Canada., Lessard M; Sherbrooke R & D Center, Agriculture and Agri-Food Canada, Sherbrooke, Quebec, Canada., Pouliot Y; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Roy D; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada., Marette A; Faculty of Medicine, Laval University, Quebec City, Quebec, Canada.; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
المصدر: The Journal of nutrition [J Nutr] 2020 Oct 12; Vol. 150 (10), pp. 2673-2686.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0404243 Publication Model: Print Cited Medium: Internet ISSN: 1541-6100 (Electronic) Linking ISSN: 00223166 NLM ISO Abbreviation: J Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: 1928-1933 : Springfield, Ill. : C. C. Thomas
مواضيع طبية MeSH: Cardiovascular Diseases/*prevention & control , Cultured Milk Products/*analysis , Gastrointestinal Microbiome/*drug effects , Metabolic Diseases/*prevention & control , Milk Proteins/*pharmacology , Obesity/*chemically induced, Animals ; Apolipoproteins B/genetics ; Apolipoproteins B/metabolism ; Bacteria/classification ; Bacteria/drug effects ; Biomarkers/blood ; Diet ; Diet, High-Fat ; Dietary Sucrose/administration & dosage ; Gene Expression Regulation/drug effects ; Male ; Mice ; Mice, Knockout ; Milk/chemistry ; Milk Proteins/chemistry ; Receptors, LDL/genetics ; Receptors, LDL/metabolism
مستخلص: Background: Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear.
Objective: We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models of diet-induced obesity and CVD.
Methods: Eight-week-old C57BL/6J wild-type (WT) and LDLr-/-ApoB100/100 (LRKO) male mice were fed for 12 and 24 wk, respectively, with a high-fat/high-sucrose diet [66% kcal lipids, 22% kcal carbohydrates (100% sucrose), 12% kcal proteins]. The protein sources of the 4 diets were 100% nondairy protein (NDP), or 50% of the NDP energy replaced by milk (MP), milk fermented by Lactobacillus helveticus (FMP), or Greek-style yogurt (YP) protein. Fecal 16S rRNA gene-based amplicon sequencing, intestinal gene expression, and glucose tolerance test were conducted. Hepatic inflammation and circulating adhesion molecules were measured by multiplex assays.
Results: Feeding WT mice for 12 wk led to a 74% increase in body weight, whereas after 24 wk the LRKO mice had a 101.5% increase compared with initial body weight. Compared with NDP and MP, the consumption of FMP and YP modulated the gut microbiota composition in a similar clustering pattern, upregulating the Streptococcus genus in both genotypes. In WT mice, feeding YP compared with NDP increased the expression of genes involved in jejunal (Reg3b, 7.3-fold, P = 0.049) and ileal (Ocln, 1.7-fold, P = 0.047; Il1-β,1.7-fold, P = 0.038; Nos2, 3.8-fold, P = 0.018) immunity and integrity. In LRKO mice, feeding YP compared with MP improved insulin sensitivity by 65% (P = 0.039). In LRKO mice, feeding with FMP versus NDP attenuated hepatic inflammation (monocyte chemoattractant protein 1, 2.1-fold, P ˂ 0.0001; IL1-β, 5.7-fold, P = 0.0003; INF-γ, 1.7-fold, P = 0.002) whereas both FMP [vascular adhesion molecule 1 (VCAM1), 1.3-fold, P = 0.0003] and YP (VCAM1, 1.04-fold, P = 0.013; intracellular adhesion molecule 1, 1.4-fold, P = 0.028) decreased circulating adhesion molecules.
Conclusion: Both fermented dairy protein products reduce cardiometabolic risk factors in diet-induced obese mice, possibly by modulating the gut microbiota.
(Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.)
References: Am J Clin Nutr. 2019 Nov 1;110(5):1201-1212. (PMID: 31504094)
Br J Nutr. 2016 Feb 28;115(4):737-50. (PMID: 26786887)
Int J Food Microbiol. 2011 Nov 1;150(2-3):81-94. (PMID: 21868118)
Int J Food Microbiol. 2003 Aug 15;85(1-2):11-21. (PMID: 12810267)
Diabetes. 2015 Jul;64(7):2398-408. (PMID: 25695945)
Adv Nutr. 2016 Nov 15;7(6):1026-1040. (PMID: 28140321)
J Vis Exp. 2017 May 19;(123):. (PMID: 28570508)
Eur J Nutr. 2018 Dec;57(8):2869-2876. (PMID: 29080977)
Physiol Behav. 2014 Sep;136:74-8. (PMID: 24704111)
Circ Res. 2018 Jan 19;122(2):369-384. (PMID: 29348256)
Diabetes. 2008 Jun;57(6):1470-81. (PMID: 18305141)
N Engl J Med. 2011 Jun 23;364(25):2392-404. (PMID: 21696306)
Peptides. 2011 Apr;32(4):835-8. (PMID: 21256171)
Int J Food Sci Nutr. 1996 Sep;47(5):391-8. (PMID: 8889624)
Food Funct. 2013 Feb;4(2):185-99. (PMID: 23111492)
Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
PLoS One. 2011;6(8):e23384. (PMID: 21858094)
Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2292-301. (PMID: 17673705)
PLoS One. 2010 Aug 16;5(8):e12191. (PMID: 20808947)
FASEB J. 2019 Apr;33(4):4921-4935. (PMID: 30596521)
Am J Clin Nutr. 2008 Jan;87(1):91-6. (PMID: 18175741)
Circulation. 2016 Jan 12;133(2):187-225. (PMID: 26746178)
FEMS Immunol Med Microbiol. 1994 Nov;10(1):55-63. (PMID: 7874079)
Front Microbiol. 2019 May 24;10:1046. (PMID: 31191465)
Pharmaceuticals (Basel). 2010 Jan 19;3(1):251-272. (PMID: 27713251)
Nutr Rev. 2018 Dec 1;76(Suppl 1):16-28. (PMID: 30452697)
Hypertension. 2012 Nov;60(5):1131-7. (PMID: 22987924)
Adv Nutr. 2018 May 1;10(suppl_2):S154-S163. (PMID: 31089734)
Appl Environ Microbiol. 2007 Aug;73(16):5261-7. (PMID: 17586664)
Gut. 2019 Mar;68(3):453-464. (PMID: 30064988)
J Biol Chem. 1957 May;226(1):497-509. (PMID: 13428781)
Nutr Rev. 2010 May;68(5):270-9. (PMID: 20500788)
Cell Host Microbe. 2016 Feb 10;19(2):227-39. (PMID: 26867181)
World J Gastroenterol. 2010 Oct 14;16(38):4773-83. (PMID: 20939105)
J Endocrinol. 2013 Aug 28;218(3):R25-36. (PMID: 23833274)
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
Nutr J. 2011 Dec 23;10:138. (PMID: 22196482)
Nutr Res. 2016 Apr;36(4):337-348. (PMID: 27001279)
Lancet. 2018 Nov 24;392(10161):2288-2297. (PMID: 30217460)
Crit Rev Anal Chem. 2015;45(2):106-11. (PMID: 25558772)
Crit Rev Food Sci Nutr. 2018 Jan 2;58(1):105-115. (PMID: 26852912)
Can J Diet Pract Res. 2006 Spring;67(1):7-13. (PMID: 16515742)
Curr Nutr Rep. 2018 Dec;7(4):171-182. (PMID: 30406514)
Diabetes Care. 1999 Sep;22(9):1462-70. (PMID: 10480510)
Microorganisms. 2016 Dec 23;5(1):. (PMID: 28025548)
Diabetes. 2007 Jul;56(7):1761-72. (PMID: 17456850)
Genome Biol. 2011 Jun 24;12(6):R60. (PMID: 21702898)
J Food Prot. 2011 May;74(5):801-11. (PMID: 21549052)
Atherosclerosis. 2003 Oct;170(2):191-203. (PMID: 14612198)
ISME J. 2014 Feb;8(2):295-308. (PMID: 24030595)
Br J Nutr. 2007 Jan;97(1):126-33. (PMID: 17217568)
Gastroenterology. 2020 Feb;158(3):652-663.e6. (PMID: 31711923)
Exp Ther Med. 2015 Mar;9(3):707-716. (PMID: 25667617)
Nutrients. 2019 Mar 04;11(3):. (PMID: 30836671)
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14. (PMID: 24912386)
Nat Rev Endocrinol. 2015 Oct;11(10):577-91. (PMID: 26260141)
Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9274-9. (PMID: 16754859)
معلومات مُعتمدة: FDN143247 Canada CIHR
فهرسة مساهمة: Keywords: bacteria; dairy products; fermentation; gut inflammation; peptides
المشرفين على المادة: 0 (Apolipoproteins B)
0 (Biomarkers)
0 (Dietary Sucrose)
0 (Milk Proteins)
0 (Receptors, LDL)
تواريخ الأحداث: Date Created: 20200905 Date Completed: 20210105 Latest Revision: 20230216
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7549311
DOI: 10.1093/jn/nxaa217
PMID: 32886125
قاعدة البيانات: MEDLINE
الوصف
تدمد:1541-6100
DOI:10.1093/jn/nxaa217