دورية أكاديمية
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
العنوان: | Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma. |
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المؤلفون: | Gibson AE; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Yeung C; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Issaq SH; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Collins VJ; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gouzoulis M; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Zhang Y; National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Ji J; National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Mendoza A; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Heske CM; Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Christine.heske@nih.gov. |
المصدر: | Oncogenesis [Oncogenesis] 2020 Sep 10; Vol. 9 (9), pp. 80. Date of Electronic Publication: 2020 Sep 10. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101580004 Publication Model: Electronic Cited Medium: Print ISSN: 2157-9024 (Print) Linking ISSN: 21579024 NLM ISO Abbreviation: Oncogenesis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Group |
مستخلص: | NAMPT mediates the rate-limiting step of the NAD salvage pathway, which maintains cellular bioenergetics and provides a necessary substrate for functions essential to rapidly proliferating cancer cells. In this study, we evaluated the efficacy and mechanisms of action of OT-82, a novel, high-potency NAMPT inhibitor with a favorable toxicity profile, in preclinical models of Ewing sarcoma (EWS), an aggressive pediatric malignancy with previously reported selective sensitivity to NAMPT inhibition. We show that OT-82 decreased NAD concentration and impaired proliferation of EWS cells in a dose-dependent manner, with IC |
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تواريخ الأحداث: | Date Created: 20200910 Latest Revision: 20210910 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7481307 |
DOI: | 10.1038/s41389-020-00264-0 |
PMID: | 32908120 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2157-9024 |
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DOI: | 10.1038/s41389-020-00264-0 |