دورية أكاديمية
أعرض في EDS

Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women.

التفاصيل البيبلوغرافية
العنوان: Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women.
المؤلفون: Magno FCCM; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil. fernandamattos.nut@gmail.com.; Department of Nutrology, Federal University of Rio de Janeiro, University Hospital Clementino Fraga Filho, Professor Rodolpho Paulo Rocco Street, 255, 9th Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-913, Brazil. fernandamattos.nut@gmail.com., Guaraná HC; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil., da Fonseca ACP; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Pavilion 108, Laboratory of Immunopharmacology, Room 44, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil., Pedrosa AP; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil., Zembrzuski VM; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil., Cabello PH; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil.; Human Genetics Laboratory, Professor José de Souza Herdy Street, 1160, Jardim Vinte E Cinco de Agosto, Duque de Caxias, RJ, 25071-202, Brazil., Cabello GMK; Oswaldo Cruz Foundation (FIOCRUZ), Oswaldo Cruz Institute (IOC), Brazil Avenue, 4365, Leônidas Deane Building, 6th Floor, Human Genetics Laboratory, Room 615, Manguinhos, Rio de Janeiro, RJ, 21040-900, Brazil., Carneiro JRI; Department of Nutrology, Federal University of Rio de Janeiro, University Hospital Clementino Fraga Filho, Professor Rodolpho Paulo Rocco Street, 255, 9th Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-913, Brazil., Rosado EL; Institute of Nutrition, Federal University of Rio de Janeiro, Carlos Chagas Filho Avenue, 373, CCS, Block J, 2nd Floor, University City, Fundão Island, Rio de Janeiro, RJ, 21941-590, Brazil.
المصدر: Eating and weight disorders : EWD [Eat Weight Disord] 2021 May; Vol. 26 (4), pp. 1079-1087. Date of Electronic Publication: 2020 Sep 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9707113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-1262 (Electronic) Linking ISSN: 11244909 NLM ISO Abbreviation: Eat Weight Disord Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Heidelberg : Springer
Original Publication: Milano, Italy : Editrice Kurtis, c1996-
مواضيع طبية MeSH: Leptin*/genetics , Obesity, Morbid*/genetics, Adult ; Body Mass Index ; Eating/genetics ; Feeding Behavior ; Female ; Ghrelin/genetics ; Humans ; Interleukin-6/genetics ; Polymorphism, Single Nucleotide ; Receptor, Melanocortin, Type 4/genetics ; Tumor Necrosis Factor-alpha
مستخلص: Purpose: The rs17782313 variant of the MC4R gene plays an important role in the obesity phenotype. Studies that evaluate environmental factors and genetic variants associated with obesity may represent a great advance in understanding the development of this disease. This work seeks to assess the association of the polymorphism of MC4R rs17782313 on plasma parameters, including leptin, ghrelin, tumor necrosis factor (TNFα) and interleukin 6 (IL6), and on the eating behaviors of morbidly obese women.
Methods: 70 adult women with BMI between 40 and 60 kg/m 2 were recruited. Laboratory and anthropometric data were recorded. Using a visual analog scale (VAS), the feelings of hunger and satiety were evaluated. The presence or absence of binge eating was evaluated through the Binge Eating Scale (BES) questionnaire. Habitual food intake was analyzed using 3-day dietary records. TaqMan ® assays were conducted using real-time PCR to assess genotype polymorphism variants from peripheral blood DNA.
Results: This study found that female patients with the MC4R rs17782313 polymorphism had high levels of ghrelin and reduced levels of IL6 in the postprandial period. We observed a higher prevalence of severe binge eating in more than 50% of women with at least one risk allele.
Conclusion: Our hypothesis is that the MC4R rs17782313 polymorphism may influence the release of ghrelin, even without being associated with feelings of hunger and satiety. More than half of women with this polymorphism exhibited severe binge eating.
Level of Evidence: Level III: case-control analytic study.
References: World Health Organization [WHO] (2016) Obesity and overweight. https://www.who.int/mediacentre/factsheets/fs311/en/ . Accessed 6 Jun 2018.
Faria AM, Mancini MC, Melo ME, Cercato C, Halpern A (2010) Recent progress and novel perspectives on obesity pharmacotherapy. Arq Bras Endocrinol Metabol 54:516–529. https://doi.org/10.1590/s0004-27302010000600003. (PMID: 10.1590/s0004-2730201000060000320857056)
Loos RJ, Bouchard C (2003) Obesity is it a genetic disorder? J Intern Med 254:401–425. https://doi.org/10.1007/bf03256449. (PMID: 10.1007/bf0325644914535962)
Ferguson LR (2006) Nutrigenomics: integrating genomic approaches into nutrition research. Mol Diagn Ther 10:101–108. https://doi.org/10.1007/bf03256449. (PMID: 10.1007/bf0325644916669608)
Marques-Lopes I, Marti A, Moreno-Aliaga MJ, Martínez A (2004) Aspectos genéticos da obesidade. Rev Nutr 17:327–338. https://doi.org/10.1590/S1415-52732004000300006. (PMID: 10.1590/S1415-52732004000300006)
Ochoa MDC, Marti A, Martinez JA (2004) Obesity studies in candidate genes. Med Clin (Barc) 122:542–551. https://doi.org/10.1016/s0025-7753(04)74300-6. (PMID: 10.1016/s0025-7753(04)74300-6)
Genbank (2018) MC4R–melanocortin 4 receptor. https://www.ncbi.nlm.nih.gov/gene . Accessed 29 Oct 2018.
Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M (2006) The MC4 receptor and control of appetite. Br J Pharmacol 149:815–827. https://doi.org/10.1038/sj.bjp.0706929. (PMID: 10.1038/sj.bjp.0706929170436702014686)
Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS et al (2015) A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci 18:863–871. https://doi.org/10.1038/nn.4011. (PMID: 10.1038/nn.4011259154764446192)
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I et al (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40:768–775. https://doi.org/10.1038/ng.140. (PMID: 10.1038/ng.140184541482669167)
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR et al (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131–141. https://doi.org/10.1016/s0092-8674(00)81865-6. (PMID: 10.1016/s0092-8674(00)81865-69019399)
Yeo GS, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S (1998) A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20:111–112. https://doi.org/10.1038/2404. (PMID: 10.1038/24049771698)
Ensembl (2017) Ensembl genome browser—MC4R rs17782313. https://www.ensembl.org/Homo_sapiens/Variation/Population?db=core . Accessed 12 Oct 2018.
Loos RJ (2011) The genetic epidemiology of melanocortin 4 receptor variants. Eur J Pharmacol 660:156–164. https://doi.org/10.1016/j.ejphar.2011.01.033. (PMID: 10.1016/j.ejphar.2011.01.03321295023)
Tschritter O, Haupt A, Preissl H, Ketterer C, Hennige AM, Sartorius T et al (2011) An obesity risk SNP (rs17782313) near the MC4R gene is associated with cerebrocortical insulin resistance in humans. J Obes 2011:283153. https://doi.org/10.1155/2011/283153. (PMID: 10.1155/2011/283153217730043136179)
Khalilitehrani A, Qorbani M, Hosseini S, Pishva H (2015) The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults. Gene 563:125–129. https://doi.org/10.1016/j.gene.2015.03.013. (PMID: 10.1016/j.gene.2015.03.01325769385)
Vega JA, Salazar G, Hodgson MI, Cataldo LR, Valladares M, Obregon AM et al (2016) Melanocortin-4 receptor gene variation is associated with eating behavior in chilean adults. Ann Nutr Metab 68:35–41. https://doi.org/10.1159/000439092. (PMID: 10.1159/00043909226588347)
World Health Organization (2011) Waist circumference and waist-hip ratio, https://apps.who.int/iris/bitstream/10665/44583/1/9789241501491_eng.pdf . Accessed 6 Jun 2018.
Kostner GM, Avogaro P, Bon GB, Cazzolato G, Quinci GB (1979) Determination of high-density lipoproteins: screening methods compared. Clin Chem 25:939–942. (PMID: 10.1093/clinchem/25.6.939)
Lott JA, Turner K (1975) Evaluation of trinder's glucose oxidase method for measuring glucose in serum and urine. Clin Chem 21:1754–1760. (PMID: 10.1093/clinchem/21.12.1754)
McGowan MW, Artiss JD, Strandbergh DR, Zak B (1983) A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin Chem 29:538–542. (PMID: 10.1093/clinchem/29.3.538)
Richmond W (1973) Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 19:1350–1356. (PMID: 10.1093/clinchem/19.12.1350)
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502. (PMID: 10.1093/clinchem/18.6.499)
Sampaio LR, Silva MdCMd, Roriz AKC, Leite VR (2012) Food Inquiry, In: Sampaio, L.R. Nutrition Assessment, vol 1 (EDUFBA2012).
Casas-Agustench P, Lopez-Uriarte P, Bullo M, Ros E, Gomez-Flores A, Salas-Salvado J (2009) Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Clin Nutr 28:39–45. https://doi.org/10.1016/j.clnu.2008.10.008. (PMID: 10.1016/j.clnu.2008.10.00819010571)
FAO/WHO/UNU (2001) Human energy requirements. Joint FAO/WHO/UNU expert consultation, Roma. https://www.fao.org/3/a-y5686e.pdf . Accessed 12 Nov 2018.
Freitas S, Lopes CS, Coutinho W, Appolinario JC (2001) Tradução e adaptação para o Português da escala de compulsão alimentar periódica. Rev Bras Psiquiatr 23:215–220. https://doi.org/10.1590/S1516-44462001000400008. (PMID: 10.1590/S1516-44462001000400008)
Flint A, Raben A, Blundell JE, Astrup A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24:38–48. https://doi.org/10.1038/sj.ijo.0801083. (PMID: 10.1038/sj.ijo.080108310702749)
Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415–445. https://doi.org/10.1146/annurev-immunol-031210-101322. (PMID: 10.1146/annurev-immunol-031210-101322)
Geraldo JM, Alfenas RC (2008) Role of diet on chronic inflammation prevention and control–current evidences. Arq Bras Endocrinol Metabol 52:951–967. https://doi.org/10.1590/s0004-27302008000600006. (PMID: 10.1590/s0004-2730200800060000618820806)
Yeung AY, Tadi P (2020) Physiology, obesity neurohormonal appetite and satiety control. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL) (updated 2020 Mar 14).
De Santis S, Cambi J, Tatti P, Bellussi L, Passali D (2015) Changes in ghrelin, leptin and pro-inflammatory cytokines after therapy in obstructive sleep apnea syndrome (OSAS) patients. Otolaryngol Pol 69:1–8. https://doi.org/10.5604/00306657.1147029. (PMID: 10.5604/00306657.114702926224223)
Iikuni N, Lam QL, Lu L, Matarese G, La Cava A (2008) Leptin and inflammation. Curr Immunol Rev 4:70–79. https://doi.org/10.2174/157339508784325046. (PMID: 10.2174/157339508784325046201981222829991)
Dixit VD, Taub DD (2005) Ghrelin and immunity: a young player in an old field. Exp Gerontol 40:900–910. https://doi.org/10.1016/j.exger.2005.09.003. (PMID: 10.1016/j.exger.2005.09.00316233968)
Lao K-M, Lim W-S, Ng D-L, Tengku-Muhammad T-S, Choo Q-C, Chew C (2013) Molecular regulation of ghrelin expression by pro-inflammatory cytokines TNF-α and IL-6 in rat pancreatic AR42J cell line. J Biol Life Sci 4:32–40. https://doi.org/10.5296/jbls.v4i1.2306. (PMID: 10.5296/jbls.v4i1.2306)
Iwakura H, Bando M, Ueda Y, Akamizu T (2017) The effects of inflammatory cytokines on the expression of ghrelin. Endocr J 64:S25–S26. https://doi.org/10.1507/endocrj.64.S25. (PMID: 10.1507/endocrj.64.S2528652539)
Arrizabalaga M, Larrarte E, Margareto J, Maldonado-Martín S, Barrenechea L, Labayen I (2014) Preliminary findings on the influence of FTO rs9939609 and MC4R rs17782313 polymorphisms on resting energy expenditure, leptin and thyrotropin levels in obese non-morbid premenopausal women. J Physiol Biochem 70(1):255–262. https://doi.org/10.1007/s13105-013-0300-5. (PMID: 10.1007/s13105-013-0300-524307561)
Krashes MJ, Lowell BB, Garfield AS (2016) Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci 19:206–219. https://doi.org/10.1038/nn.4202. (PMID: 10.1038/nn.4202268145905244821)
Srivastava A, Mittal B, Prakash J, Narain VS, Natu SM, Srivastava N (2014) Evaluation of MC4R [rs17782313, rs17700633], AGRP [rs3412352] and POMC [rs1042571] polymorphisms with obesity in Northern India. Oman Med J 29:114–118. https://doi.org/10.5001/omj.2014.28. (PMID: 10.5001/omj.2014.28247159383976726)
Stutzmann F, Cauchi S, Durand E et al (2009) Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. Int J Obes. 33(1):373–378. https://doi.org/10.1038/ijo.2008.279. (PMID: 10.1038/ijo.2008.279)
Yilmaz Z, Davis C, Loxton NJ, Kaplan AS, Levitan RD, Carter JC et al (2015) Association between MC4R rs17782313 polymorphism and overeating behaviors. Int J Obes (Lond) 39:114–120. https://doi.org/10.1038/ijo.2014.79. (PMID: 10.1038/ijo.2014.79)
Raymond NC, Peterson RE, Bartholome LT, Raatz SK, Jensen MD, Levine JA (2012) Comparisons of energy intake and energy expenditure in overweight and obese women with and without binge eating disorder. Obesity (Silver Spring) 20(4):765–772. https://doi.org/10.1038/oby.2011.312. (PMID: 10.1038/oby.2011.312)
Valette M, Bellisle F, Carette C, Poitou C, Dubern B, Paradis G et al (2013) Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review. Int J Obes (Lond) 37:1027–1035. https://doi.org/10.1038/ijo.2012.169. (PMID: 10.1038/ijo.2012.169)
Drabsch T, Gatzemeier J, Pfadenhauer L, Hauner H, Holzapfel C (2018) Associations between single nucleotide polymorphisms and total energy, carbohydrate, and fat intakes: a systematic review. Adv Nutr. 9(4):425–453. https://doi.org/10.1093/advances/nmy024. (PMID: 10.1093/advances/nmy024300322286054249)
Abeso (2016) Diretrizes Brasileiras de obesidade. https://www.abeso.org.br/uploads/downloads/92/57fccc403e5da.pdf . Accessed 2 Nov 2018.
Malachias MVB, Souza WKSB, Plavnik FL, Rodrigues CIS, Brandão AA, Neves MFT et al (2017) 7ª diretriz Brasileira de hipertensão arterial. https://publicacoes.cardiol.br/2014/diretrizes/2016/05_HIPERTENSAO_ARTERIAL.pdf . Accessed 4 Nov 2018.
United States Department of Agriculture (2003) Dietary reference intakes, https://www.nationalacademies.org/hmd/~/media/Files/Activity%2520Files/Nutrition/DRI-Tables/5Summary%2520TableTables%252014.pdf?la=en . Accessed 3 Nov 2018.
Wehling H, Lusher J (2019) People with a body mass index ≥ 30 under-report their dietary intake: a systematic review. J Health Psychol 24(14):2042–2059. https://doi.org/10.1177/1359105317714318. (PMID: 10.1177/135910531771431828810493)
فهرسة مساهمة: Keywords: Eating behavior; Ghrelin; Leptin; Morbid obesity; rs17782313
المشرفين على المادة: 0 (Ghrelin)
0 (Interleukin-6)
0 (Leptin)
0 (MC4R protein, human)
0 (Receptor, Melanocortin, Type 4)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20200912 Date Completed: 20210623 Latest Revision: 20220531
رمز التحديث: 20231215
DOI: 10.1007/s40519-020-01003-5
PMID: 32918257
قاعدة البيانات: MEDLINE
الوصف
تدمد:1590-1262
DOI:10.1007/s40519-020-01003-5