دورية أكاديمية
Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection.
العنوان: | Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection. |
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المؤلفون: | Algassim AA; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia. A.Algassim@ksmc.med.sa.; Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. A.Algassim@ksmc.med.sa., Elghazaly AA; Department of Hematology and Oncology, King Saud Medical City, Riyadh, Saudi Arabia., Alnahdi AS; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia., Mohammed-Rahim OM; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia., Alanazi AG; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia.; Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Aldhuwayhi NA; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia.; Department of Medicine, Prince Mohammed Medical City, Sakaka, Al-Jouf, Saudi Arabia., Alanazi MM; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Almutairi MF; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Aldeailej IM; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Kamli NA; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Aljurf MD; Oncology Center, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. |
المصدر: | Annals of hematology [Ann Hematol] 2021 Jan; Vol. 100 (1), pp. 37-43. Date of Electronic Publication: 2020 Sep 12. |
نوع المنشور: | Comparative Study; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York : Springer International, c1991- |
مواضيع طبية MeSH: | Anemia, Hemolytic, Autoimmune*/blood , Anemia, Hemolytic, Autoimmune*/mortality , Anemia, Hemolytic, Autoimmune*/virology , COVID-19*/blood , COVID-19*/mortality , SARS-CoV-2*, Hemoglobins/*metabolism, Adult ; Aged ; Cross-Sectional Studies ; Disease-Free Survival ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Survival Rate |
مستخلص: | Higher levels of D-dimer, LDH, and ferritin, all have been associated with the poor prognosis of COVID-19. In a disease where there are acute inflammation and compromised oxygenation, we investigated the impact of initial hemoglobin (Hgb) levels at Emergency Department (ED) triage on the severity and the clinical course of COVID-19. We conducted a cross-sectional study on 601 COVID-19 patients in a COVID-19 national referral center between 13 and 27 June 2020. All adult patients presented at our hospital that required admission or hotel isolation were included in this study. Patients admitted to the intensive care unit (ICU) had a lower initial Hgb than those admitted outside the ICU (12.84 g/dL vs. 13.31 g/dL, p = 0.026) and over the course of admission; the prevalence of anemia (Hgb < 12.5 g/dL) was 65% in patients admitted to ICU, whereas it was only 43% in non-ICU patients (odds ratio of 2.464, 95% CI 1.71-3.52). Anemic ICU patients had a higher mortality compared with non-anemic ICU patients (hazard ratio = 1.88, log-rank p = 0.0104). A direct agglutination test (DAT) for all anemic patients showed that 14.7% of ICU patients and 9% of non-ICU patients had autoimmune hemolytic anemia (AIHA). AIHA patients had significantly longer length of hospital stay compared with anemic patients without AIHA (17.1 days vs. 14.08 days, p = 0.034). Lower Hgb level at hospital presentation could be a potential surrogate for COVID-19 severity. |
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فهرسة مساهمة: | Keywords: AIHA; Anemia; COVID-19; Hemolysis; Prognosis |
المشرفين على المادة: | 0 (Hemoglobins) |
تواريخ الأحداث: | Date Created: 20200912 Date Completed: 20210111 Latest Revision: 20220218 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7486165 |
DOI: | 10.1007/s00277-020-04256-3 |
PMID: | 32918594 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-0584 |
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DOI: | 10.1007/s00277-020-04256-3 |