دورية أكاديمية
أعرض في EDS

Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection.

التفاصيل البيبلوغرافية
العنوان: Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection.
المؤلفون: Algassim AA; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia. A.Algassim@ksmc.med.sa.; Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. A.Algassim@ksmc.med.sa., Elghazaly AA; Department of Hematology and Oncology, King Saud Medical City, Riyadh, Saudi Arabia., Alnahdi AS; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia., Mohammed-Rahim OM; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia., Alanazi AG; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia.; Department of Medicine, Prince Sultan Military Medical City, Riyadh, Saudi Arabia., Aldhuwayhi NA; Department of Medicine, King Saud Medical City, Riyadh, Saudi Arabia.; Department of Medicine, Prince Mohammed Medical City, Sakaka, Al-Jouf, Saudi Arabia., Alanazi MM; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Almutairi MF; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Aldeailej IM; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Kamli NA; Regional Laboratory and Blood Bank, Ministry of Health, Riyadh, Saudi Arabia., Aljurf MD; Oncology Center, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
المصدر: Annals of hematology [Ann Hematol] 2021 Jan; Vol. 100 (1), pp. 37-43. Date of Electronic Publication: 2020 Sep 12.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Verlag
Original Publication: Berlin ; New York : Springer International, c1991-
مواضيع طبية MeSH: Anemia, Hemolytic, Autoimmune*/blood , Anemia, Hemolytic, Autoimmune*/mortality , Anemia, Hemolytic, Autoimmune*/virology , COVID-19*/blood , COVID-19*/mortality , SARS-CoV-2*, Hemoglobins/*metabolism, Adult ; Aged ; Cross-Sectional Studies ; Disease-Free Survival ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Survival Rate
مستخلص: Higher levels of D-dimer, LDH, and ferritin, all have been associated with the poor prognosis of COVID-19. In a disease where there are acute inflammation and compromised oxygenation, we investigated the impact of initial hemoglobin (Hgb) levels at Emergency Department (ED) triage on the severity and the clinical course of COVID-19. We conducted a cross-sectional study on 601 COVID-19 patients in a COVID-19 national referral center between 13 and 27 June 2020. All adult patients presented at our hospital that required admission or hotel isolation were included in this study. Patients admitted to the intensive care unit (ICU) had a lower initial Hgb than those admitted outside the ICU (12.84 g/dL vs. 13.31 g/dL, p = 0.026) and over the course of admission; the prevalence of anemia (Hgb < 12.5 g/dL) was 65% in patients admitted to ICU, whereas it was only 43% in non-ICU patients (odds ratio of 2.464, 95% CI 1.71-3.52). Anemic ICU patients had a higher mortality compared with non-anemic ICU patients (hazard ratio = 1.88, log-rank p = 0.0104). A direct agglutination test (DAT) for all anemic patients showed that 14.7% of ICU patients and 9% of non-ICU patients had autoimmune hemolytic anemia (AIHA). AIHA patients had significantly longer length of hospital stay compared with anemic patients without AIHA (17.1 days vs. 14.08 days, p = 0.034). Lower Hgb level at hospital presentation could be a potential surrogate for COVID-19 severity.
References: J Am Coll Cardiol. 2004 Sep 1;44(5):959-66. (PMID: 15337204)
Transfus Med Hemother. 2015 Sep;42(5):294-301. (PMID: 26696797)
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):625-631. (PMID: 27913538)
J Thromb Haemost. 2020 Jun;18(6):1469-1472. (PMID: 32302435)
Lancet Infect Dis. 2020 Oct;20(10):1135-1140. (PMID: 32526193)
J Pediatr. 1995 Dec;127(6):901-4. (PMID: 8523186)
Am J Med. 2013 Sep;126(9):789-97. (PMID: 23856021)
Am J Hematol. 2020 Jun;95(6):E131-E134. (PMID: 32129508)
Cell Stress Chaperones. 2020 May;25(3):381-382. (PMID: 32314313)
Br J Haematol. 2020 Jul;190(2):e61-e64. (PMID: 32420612)
Ann Hematol. 2020 Jul;99(7):1679-1680. (PMID: 32542444)
Blood. 2019 Jan 3;133(1):40-50. (PMID: 30401705)
Circulation. 2019 Nov 12;140(20):1661-1678. (PMID: 31416350)
JAMA. 2020 Apr 28;323(16):1574-1581. (PMID: 32250385)
Br J Haematol. 2020 Jul;190(1):31-32. (PMID: 32369626)
Lancet Haematol. 2020 Aug;7(8):e575-e582. (PMID: 32619411)
JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570)
BMC Med. 2020 Jun 3;18(1):168. (PMID: 32493370)
Am J Hematol. 2002 Apr;69(4):258-71. (PMID: 11921020)
J Thromb Haemost. 2020 Apr;18(4):844-847. (PMID: 32073213)
Circulation. 2005 Apr 26;111(16):2042-9. (PMID: 15824203)
Br J Haematol. 2020 Aug;190(4):e183-e184. (PMID: 32460350)
N Engl J Med. 2020 Jun 25;382(26):2574-2576. (PMID: 32302082)
Lancet. 2020 Feb 15;395(10223):497-506. (PMID: 31986264)
Am Heart J. 2013 Jun;165(6):964-971.e1. (PMID: 23708168)
Pediatr Blood Cancer. 2020 Sep;67(9):e28503. (PMID: 32564495)
Blood. 2006 May 15;107(10):4142-8. (PMID: 16434484)
Haematologica. 2014 Oct;99(10):1547-54. (PMID: 25271314)
Nat Med. 2020 Jul;26(7):1017-1032. (PMID: 32651579)
J Thromb Haemost. 2020 May;18(5):1094-1099. (PMID: 32220112)
JAMA. 2020 Jul 21;324(3):294-296. (PMID: 32511676)
Lancet. 2020 Mar 28;395(10229):1033-1034. (PMID: 32192578)
N Engl J Med. 1999 Feb 11;340(6):409-17. (PMID: 9971864)
Br J Haematol. 2020 Jul;190(2):e92-e93. (PMID: 32453861)
Br J Haematol. 2020 Jul;190(1):29-31. (PMID: 32374906)
Resuscitation. 2014 May;85(5):587-94. (PMID: 24467882)
Nat Rev Immunol. 2020 Jun;20(6):363-374. (PMID: 32346093)
Blood. 1997 Mar 1;89(5):1787-92. (PMID: 9057664)
فهرسة مساهمة: Keywords: AIHA; Anemia; COVID-19; Hemolysis; Prognosis
المشرفين على المادة: 0 (Hemoglobins)
تواريخ الأحداث: Date Created: 20200912 Date Completed: 20210111 Latest Revision: 20220218
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7486165
DOI: 10.1007/s00277-020-04256-3
PMID: 32918594
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0584
DOI:10.1007/s00277-020-04256-3