دورية أكاديمية
Pehuén (Araucaria araucana) seed residues are a valuable source of natural antioxidants with nutraceutical, chemoprotective and metal corrosion-inhibiting properties.
| العنوان: | Pehuén (Araucaria araucana) seed residues are a valuable source of natural antioxidants with nutraceutical, chemoprotective and metal corrosion-inhibiting properties. |
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| المؤلفون: | Gallia MC; Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN, CONICET-UNCo), Neuquén, Argentina; School of Medicine, Comahue National University, Argentina., Bachmeier E; School of Odontology, Córdoba National University, Córdoba, Argentina., Ferrari A; Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN, CONICET-UNCo), Neuquén, Argentina; School of Medicine, Comahue National University, Argentina., Queralt I; Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain., Mazzeo MA; School of Odontology, Córdoba National University, Córdoba, Argentina., Bongiovanni GA; Institute of Research and Development in Process Engineering, Biotechnology and Alternative Energies (PROBIEN, CONICET-UNCo), Neuquén, Argentina; School of Agricultural Sciences, Comahue National University, Argentina. Electronic address: guillermina.bongiovanni@probien.gob.ar. |
| المصدر: | Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104175. Date of Electronic Publication: 2020 Aug 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Dietary Supplements*, Antioxidants/*pharmacology , Araucaria araucana/*chemistry , Biological Products/*pharmacology , Protective Agents/*pharmacology , Seeds/*chemistry, Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Biological Products/chemistry ; Biological Products/isolation & purification ; Biphenyl Compounds/antagonists & inhibitors ; Chlorocebus aethiops ; Corrosion ; Dose-Response Relationship, Drug ; Male ; Molecular Structure ; Picrates/antagonists & inhibitors ; Protective Agents/chemistry ; Protective Agents/isolation & purification ; Rats ; Rats, Wistar ; Structure-Activity Relationship ; Vero Cells |
| مستخلص: | In the last decade, green chemistry has been attracting great interest in many contexts, including, among others, natural antioxidants. However, only a few works deal with natural residue extracts and biowaste, which could be an efficient, economical and environmentally friendly source for the production of useful compounds. In this study, we look for antioxidant activity in Araucaria araucana seeds, an iconic pine species of the Argentine and Chilean Patagonia commonly known as "pehuén". Piñones are the edible pehuén seeds, and it is estimated that approximately 40 tons of piñones are harvested annually in Argentina and Chile. The chemical composition, antioxidants, metal corrosion-inhibiting properties and biological activity of edible and discarded piñón tissues were determined. Acute toxicity was discarded by in vitro testing and double fluorescent staining. Biological activity was evaluated in vivo by determining redox markers in salivary glands from rats treated with Cyclophosphamide (an oncological drug). All piñón tissues had antioxidants and antioxidant activity, with the coats showing the highest levels (up to 404 µg ascorbic acid equivalent per mg). The coats, in particular, had high gallic acid, catechin, quercetin and tannin contents, and more antioxidant activity, polyphenols and flavonoids than berries from the region. Results by X-ray fluorescence spectrometry showed that Na, Mg, P, S, Cl, K, and Ca were majority elements in the coat, embryo and endosperm. Furthermore, coat extract also showed significant anti-corrosion activity and in vivo protection against oxidative damage. The results indicate that piñón biowaste is a low-cost attractive source of natural antioxidants with potential nutraceutical, medical and metal corrosion protection applications. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anticorrosive; Circular economy; Corrosive inhibitor; Cyclophosphamide; EDXRF; Green chemistry; Natural product; Quercetin; Tannins; Waste |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Biological Products) 0 (Biphenyl Compounds) 0 (Picrates) 0 (Protective Agents) DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl) |
| تواريخ الأحداث: | Date Created: 20200913 Date Completed: 20210315 Latest Revision: 20210315 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bioorg.2020.104175 |
| PMID: | 32920353 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2020.104175 |