دورية أكاديمية
Epilepsy-associated neurocognitive disorders (EAND) in an onchocerciasis-endemic rural community in Cameroon: A population-based case-control study.
| العنوان: | Epilepsy-associated neurocognitive disorders (EAND) in an onchocerciasis-endemic rural community in Cameroon: A population-based case-control study. |
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| المؤلفون: | Njamnshi AK; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon. Electronic address: alfred.njamnshi@brainafrica.org., Chokote ES; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Ngarka L; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Nfor LN; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Tabah EN; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon; Ministry of Public Health, Yaoundé, Cameroon., Atchou JGB; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Angwafor SA; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Department of Neurology, University College London, London, United Kingdom; Faculty of Health Sciences, University of Bamenda, Bamenda, Cameroon., Nkouonlack C; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Department of Neurology, Regional Hospital Buea, Buea, Cameroon; Department of Clinical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon., Mengnjo MK; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Njamnshi WY; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon; Department of Neurology and Neuropsychology, University of Fribourg, Fribourg, Switzerland., Dema F; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Ministry of Public Health, Yaoundé, Cameroon., Tatah GY; Department of Neurology, Central Hospital Yaoundé, Yaoundé, Cameroon; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Neurology Department, CH Saint-Nazaire, Saint-Nazaire, France., Zoung-KanyiBissek AC; Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon; Department of Health Operations Research, Ministry of Public Health, Yaoundé, Cameroon., Annoni JM; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon & Geneva, Switzerland; Department of Neurology and Neuropsychology, University of Fribourg, Fribourg, Switzerland., Ruffieux N; Department of Special Education, University of Fribourg, Fribourg, Switzerland. |
| المصدر: | Epilepsy & behavior : E&B [Epilepsy Behav] 2020 Nov; Vol. 112, pp. 107437. Date of Electronic Publication: 2020 Sep 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Diego, CA : Academic Press, c2000- |
| مواضيع طبية MeSH: | Epilepsy*/epidemiology , Epilepsy*/etiology , Onchocerciasis*, Adult ; Africa South of the Sahara ; Cameroon/epidemiology ; Case-Control Studies ; Humans ; Neurocognitive Disorders ; Neuropsychological Tests ; Rural Population |
| مستخلص: | Background: Epilepsy affects at least 50 million individuals worldwide, especially in sub-Saharan Africa (sSA). Cognitive impairment is common in people with epilepsy (PWE) yet, little is known on the burden of cognitive impairment in people with epilepsy in sSA. This study was thus designed to assess cognitive impairment in PWE or epilepsy-associated neurocognitive disorders (EAND) in a rural population in Cameroon. Methods: This was a case-control study including PWE and age/sex-matched healthy controls from July to September 2017 in Bilomo, a village in the Mbam and Kim Division. The Montreal Cognitive Assessment (MoCA), International HIV Dementia Scale (IHDS), Dubois' Five Word testing, Frontal Assessment Battery (FAB), Isaac's Set Test and the Clock drawing test were administered to the study participants to evaluate global and specific cognitive functions. Results: Eighty participants were included (40 cases and 40 controls) with a mean age of 25.78 years. Using the MoCA, 87.5% of cases had cognitive impairment, against 37.5% of controls (p < 0.001; OR 11.67; CI 3.40-45.09). Using the IHDS, the prevalence of global cognitive impairment was 84.6% among the cases against 40% for the controls (p = <0.001; OR 7.07; CI 2.29-29.19). Specifically, executive function deficits (92.5% of cases vs 40.0% of controls p = <0.001 OR = 18.50 CI; 4.48-105.08) and decreased verbal fluency (100% of cases against 45% of controls p < 0.001) were the most affected cognitive domains. Longer duration of epilepsy and higher seizure frequency were associated with global cognitive impairment. Low level of education was associated with both decreased verbal fluency and executive dysfunction while a longer stay in Bilomo correlated with poor results on the Isaac's Set Test. Conclusion: The prevalence of cognitive impairment appears to be much higher in PWE in the Mbam valley, particularly decreased executive function and verbal fluency, than in people without epilepsy. Longer disease duration, higher seizure frequency, low level of education and length of stay in Bilomo are associated with poorer cognitive performance. More studies are needed to refine evaluation tools to better characterize and manage EAND in sSA. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cameroon; Cognitive impairment; Epilepsy; Executive function; Rural population; Verbal fluency |
| تواريخ الأحداث: | Date Created: 20200913 Date Completed: 20210414 Latest Revision: 20210414 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.yebeh.2020.107437 |
| PMID: | 32920377 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1525-5069 |
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| DOI: | 10.1016/j.yebeh.2020.107437 |