دورية أكاديمية
Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing.
| العنوان: | Bicontinuous microemulsions containing Melaleuca alternifolia essential oil as a therapeutic agent for cutaneous wound healing. |
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| المؤلفون: | de Assis KMA; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., da Silva Leite JM; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., de Melo DF; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Borges JC; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Santana LMB; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Dos Reis MML; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Moreira VM; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., da Rocha WRV; Laboratory of Microbiology, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Catão RMR; Laboratory of Microbiology, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Dos Santos SG; Research Institute for Drugs and Medicines, Federal University of Paraíba, João Pessoa, Paraíba, Brazil., da Silva Portela A; Medical Sciences Faculty, University Center UniFacisa, Campina Grande, Paraíba, Brazil., de Sousa Silva SM; Medical Sciences Faculty, University Center UniFacisa, Campina Grande, Paraíba, Brazil., de Oliveira TKB; Medical Sciences Faculty, University Center UniFacisa, Campina Grande, Paraíba, Brazil., de Souza da Silveira JW; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil., Pires EG; Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil., Nonaka CFW; Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil., Sanches FAC; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil.; Federal Institute of Education, Science and Technology Baiano, IFBA, Campus Catu, Catu, Bahia, Brazil., de Lima Damasceno BPG; Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Paraiba, Brazil. bolivarpgld@hotmail.com.; Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba (UEPB), Campina Grande, Paraiba, Brazil. bolivarpgld@hotmail.com. |
| المصدر: | Drug delivery and translational research [Drug Deliv Transl Res] 2020 Dec; Vol. 10 (6), pp. 1748-1763. Date of Electronic Publication: 2020 Sep 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer |
| مواضيع طبية MeSH: | Anti-Bacterial Agents*/pharmacology , Melaleuca*/chemistry , Tea Tree Oil*/pharmacology, Wound Healing/*drug effects, Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects |
| مستخلص: | The Melaleuca alternifolia essential oil (MEO) has been widely used due to its healing and antimicrobial action. Its incorporation into drug delivery systems is a reality, and numerous studies have already been developed for this purpose. In this regard, the aim of this work was to develop, characterize, and evaluate the in vivo pharmacological activity of bicontinuous microemulsions (BME) containing MEO. Through diagram construction, a formulation consisting of Kolliphor® HS 15 (31.05%), Span® 80 (3.45%), isopropyl myristate (34.5%), and distilled water (31%) was selected and MEO was incorporated in the proportion of 3.45% (v/v). Morphological analysis characterization confirms that the system studied herein is a BME. The evaluated formulation showed physicochemical characteristics that allow its topical use. Rheologically, samples were characterized as pseudo-plastic non-Newtonian thixotropic fluids. The chromatographic method developed is in accordance with the current recommendations. The extraction method used assured a 100% recovery of the pharmacological marker (terpinen-4-ol). In vivo studies suggest that BME loaded with MEO may contribute to the healing process of skin wounds. In addition, it demonstrated antibacterial activity for Gram-positive and Gram-negative bacteria. Therefore, the BME system loaded with MEO is promising as a healing and antimicrobial agent for skin wounds.Graphical abstract. |
| معلومات مُعتمدة: | 001 International Coordenação de Aperfeiçoamento de Pessoal de Nível Superior |
| فهرسة مساهمة: | Keywords: Antibacterial activity; Drug delivery systems; Pharmacological effects; Physicochemical characterization; Tea tree |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 68647-73-4 (Tea Tree Oil) |
| تواريخ الأحداث: | Date Created: 20200914 Date Completed: 20211101 Latest Revision: 20211101 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s13346-020-00850-0 |
| PMID: | 32924099 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2190-3948 |
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| DOI: | 10.1007/s13346-020-00850-0 |