دورية أكاديمية
أعرض في EDS

Three-dimensional Neuroretinal Rim Thickness and Visual Fields in Glaucoma: A Broken-stick Model.

التفاصيل البيبلوغرافية
العنوان: Three-dimensional Neuroretinal Rim Thickness and Visual Fields in Glaucoma: A Broken-stick Model.
المؤلفون: Liu WW; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School., McClurkin M; Harvard Medical School., Tsikata E; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School., Hui PC; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School., Elze T; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School., Celebi ARC; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School.; Acibadem University School of Medicine, Istanbul., Khoueir Z; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School.; Beirut Eye and ENT Specialist Hospital, Saint-Joseph University Medical School, Beirut, Lebanon., Lee R; Harvard Medical School.; University of Southern California Roski Eye Institute., Shieh E; Harvard Medical School.; Department of Ophthalmology, University of California, Los Angeles, CA., Simavli H; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School.; Department of Ophthalmology, Pamukkale Universitesi, Denizli, Turkey., Que C; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School.; Romblon Provincial Hospital, Romblon, Philippines., Guo R; Department of Ophthalmology, Massachusetts Eye and Ear., de Boer J; Harvard Medical School.; Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, MA.; LaserLaB Amsterdam, Department of Physics and Astronomy, Vrije Universiteit.; Department of Ophthalmology, VU Medical Center, Amsterdam, The Netherlands., Chen TC; Department of Ophthalmology, Massachusetts Eye and Ear.; Harvard Medical School.
المصدر: Journal of glaucoma [J Glaucoma] 2020 Oct; Vol. 29 (10), pp. 952-963.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : Philadelphia, PA : Wolters Kluwer Health, Inc.
Original Publication: New York, N.Y. : Raven Press, c1992-
مواضيع طبية MeSH: Glaucoma, Open-Angle/*diagnosis , Nerve Fibers/*pathology , Optic Disk/*pathology , Optic Nerve Diseases/*diagnosis , Retinal Ganglion Cells/*pathology , Vision Disorders/*diagnosis , Visual Fields/*physiology, Adult ; Aged ; Cross-Sectional Studies ; Female ; Glaucoma, Open-Angle/physiopathology ; Humans ; Imaging, Three-Dimensional ; Intraocular Pressure/physiology ; Male ; Middle Aged ; Models, Theoretical ; Optic Disk/diagnostic imaging ; Optic Nerve Diseases/physiopathology ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Vision Disorders/physiopathology ; Visual Field Tests
مستخلص: Precis: In open-angle glaucoma, when neuroretinal rim tissue measured by volumetric optical coherence tomography (OCT) scans is below a third of the normal value, visual field (VF) damage becomes detectable.
Purpose: To determine the amount of neuroretinal rim tissue thickness below which VF damage becomes detectable.
Methods: In a retrospective cross-sectional study, 1 eye per subject (of 57 healthy and 100 open-angle glaucoma patients) at an academic institution had eye examinations, VF testing, spectral-domain OCT retinal nerve fiber layer (RNFL) thickness measurements, and optic nerve volumetric scans. Using custom algorithms, the minimum distance band (MDB) neuroretinal rim thickness was calculated from optic nerve scans. "Broken-stick" regression was performed for estimating both the MDB and RNFL thickness tipping-point thresholds, below which were associated with initial VF defects in the decibel scale. The slopes for the structure-function relationship above and below the thresholds were computed. Smoothing curves of the MDB and RNFL thickness covariates were evaluated to examine the consistency of the independently identified tipping-point pairs.
Results: Plots of VF total deviation against MDB thickness revealed plateaus of VF total deviation unrelated to MDB thickness. Below the thresholds, VF total deviation decreased with MDB thickness, with the associated slopes significantly greater than those above the thresholds (P<0.014). Below 31% of global MDB thickness, and 36.8% and 43.6% of superior and inferior MDB thickness, VF damage becomes detectable. The MDB and RNFL tipping points were in good accordance with the correlation of the MDB and RNFL thickness covariates.
Conclusions: When neuroretinal rim tissue, characterized by MDB thickness in OCT, is below a third of the normal value, VF damage in the decibel scale becomes detectable.
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معلومات مُعتمدة: R01 EY030575 United States EY NEI NIH HHS; R21 EY030142 United States EY NEI NIH HHS; UL1 RR025758 United States RR NCRR NIH HHS; P30 EY003790 United States EY NEI NIH HHS; R21 EY030631 United States EY NEI NIH HHS; UL1 TR002541 United States TR NCATS NIH HHS
تواريخ الأحداث: Date Created: 20200914 Date Completed: 20210122 Latest Revision: 20221005
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7541591
DOI: 10.1097/IJG.0000000000001604
PMID: 32925518
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-481X
DOI:10.1097/IJG.0000000000001604