دورية أكاديمية
Partially saturated canthaxanthin alleviates aging-associated oxidative stress in D-galactose administered male wistar rats.
| العنوان: | Partially saturated canthaxanthin alleviates aging-associated oxidative stress in D-galactose administered male wistar rats. |
|---|---|
| المؤلفون: | Mathimaran A; Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Vallam, Thanjavur, Tamil Nadu, India.; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Kumar A; Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Vallam, Thanjavur, Tamil Nadu, India. anbarasuk@pmu.edu., Prajapati G; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Ampapathi RS; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India.; CSIR-Academy of Scientific and Innovative Research (CSIR-AcSIR), Ghaziabad, Uttar Pradesh, India., Bora HK; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Guha R; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India. rajdeep.guha@cdri.res.in.; CSIR-Academy of Scientific and Innovative Research (CSIR-AcSIR), Ghaziabad, Uttar Pradesh, India. rajdeep.guha@cdri.res.in. |
| المصدر: | Biogerontology [Biogerontology] 2021 Feb; Vol. 22 (1), pp. 19-34. Date of Electronic Publication: 2020 Sep 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Dordrecht ; Boston : Kluwer Academic, c2000- |
| مواضيع طبية MeSH: | Canthaxanthin* , Galactose*, Aging ; Animals ; Antioxidants/pharmacology ; Aspergillus ; Catalase/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation ; Male ; Malondialdehyde ; Oxidative Stress ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism |
| مستخلص: | It has been earlier reported that partially saturated canthaxanthin (PSC) from Aspergillus carbonarius mutant is non-toxic, has anti-lipid peroxidation activity and can induce apoptosis in prostate cancer cell lines. In the present study, the antiaging effect of PSC was explored in D-galactose administered male wistar rats. 8-10 weeks old, male wistar rats were randomly divided into (i) Vehicle Control Group (VCG), (ii) Aged Control Group (ACG), (iii) Aged + α Lipoic Acid Group (ALG) and (iv) Aged + Partially saturated canthaxanthin Group (APG). Rats received D-galactose (300 mg /kg bwt/day; i.p.) alone (ACG) or together with PSC (APG) (20 mg/kg bwt/day; oral) and α Lipoic Acid (ALG) (80 mg/kg bwt/day; oral) for 10 weeks. Rats in VCG were injected with the same volume of physiological saline (i.p.) and fed with olive oil (vehicle). In vitro protein oxidation and DNA oxidation inhibition, in vivo malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities were determined. In addition, brain neurotransmitters, dopamine and serotonin were estimated by NMR. PSC treatment showed inhibition against protein and DNA oxidation. PSC effectively improved D-galactose induced aging rats by inducing a protective effect through up-regulation of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and brain neurotransmitters and downregulated malondialdehyde (MDA) and monoamineoxidase (MAO) levels. Thus, PSC appears to be a functional compound having antioxidant and antiaging properties. |
| References: | Ames BN, Shigenaga MK, Hagen TM (1993) Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90(17):7915–7922. (PMID: 8367443) Austad SN, Fischer KE (2016) Sex differences in lifespan. Cell Metab 23:1022–1033. (PMID: 273045044932837) Babin A, Saciat C, Teixeira M, Troussard J-P, Motreuil S, Moreau J et al (2015) Limiting immunopathology: interaction between carotenoids and enzymatic antioxidant defences. Dev Comp Immunol 49(2):278–281. (PMID: 25524820) Banji D, Banji OJ, Dasaroju S, Annamalai A (2013) Piperine and curcumin exhibit synergism in attenuating D-galactose induced senescence in rats. Eur J Pharmacol 703(1–3):91–99. (PMID: 23200897) Blokland A (1995) Acetylcholine: a neurotransmitter for learning and memory? Brain Res Rev 21(3):285–300. (PMID: 8806017) Bonnet U (2003) Moclobemide: therapeutic use and clinical studies. CNS Drug Rev 9(1):97–140. (PMID: 125959136741704) Bonsall EK, Mundorff JZ, Ekvall VK, Ekvall SW (2017) 12 Nutrients, neurotransmitters, and brain dysfunction. Pediatric and adult nutrition in chronic diseases, developmental disabilities, and hereditary metabolic disorders: prevention, assessment, and treatment 103. Bose KSC, Agrawal B (2007) Effect of lycopene from tomatoes (cooked) on plasma antioxidant enzymes, lipid peroxidation rate and lipid profile in grade-I hypertension. Annals of Nutrition Metabolism 51(5):477–481. (PMID: 18025823) Britz-Mckibbin P, Wong J, Chen DD (1999) Analysis of epinephrine from fifteen different dental anesthetic formulations by capillary electrophoresis. J Chromatogr A 853(1–2):535–540. (PMID: 10486763) Castegna A, Aksenov M, Thongboonkerd V, Klein JB, Pierce WM, Booze R et al (2002) Proteomic identification of oxidatively modified proteins in Alzheimer’s disease brain. Part II: dihydropyrimidinase-related protein 2, α‐enolase and heat shock cognate 71. J Neurochem 82(6):1524–1532. (PMID: 12354300) Chen N-Y, Liu C-W, Lin W, Ding Y, Bian Z-y, Huang L et al (2017) Extract of fructus cannabis ameliorates learning and memory impairment induced by D-galactose in an aging rats model. Evid-Based Complement Altern Med. Crawford A, Fassett RG, Geraghty DP, Kunde DA, Ball MJ, Robertson IK et al (2012) Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease. Gene 501(2):89–103. (PMID: 22525041) Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J et al (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R‐α‐lipoic acid. J Neurosci Res 84(3):647–654. (PMID: 16710848) Dasgupta A, Zheng J, Perrone-Bizzozero NI, Bizzozero OA (2013) Increased carbonylation, protein aggregation and apoptosis in the spinal cord of mice with experimental autoimmune encephalomyelitis. Davies I, O’neill PA, Mclean KA, Catania J, Bennett D (1995) Age-associated alterations in thirst and arginine vasopressin in response to a water or sodium load. Age Ageing 24(2):151–159. (PMID: 7793338) De Iuliis A, Grigoletto J, Recchia A, Giusti P, Arslan P (2005) A proteomic approach in the study of an animal model of Parkinson’s disease. Clin Chim Acta 357(2):202–209. (PMID: 15946658) Delgado-Vargas F, Jiménez A, Paredes-López O (2000) Natural pigments: carotenoids, anthocyanins, and betalains—characteristics, biosynthesis, processing, and stability. Crit Rev Food Sci Nutr 40(3):173–289. (PMID: 10850526) Devaraj S, Mathur S, Basu A, Aung HH, Vasu VT, Meyers S et al (2008) A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J Am Coll Nutr 27(2):267–273. (PMID: 186895582677959) Dröge W (2003) Oxidative stress and aging. In: Hypoxia. Springer, pp 191–200. Dubey T, Sahu G, Kumari S, Yadav BS, Sahu AN (2018) Role of herbal drugs on neurotransmitters for treating various CNS disorders: A review. Ellison DW, Beal MF, Martin JB (1987) Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection. J Neurosci Methods 19(4):305–315. (PMID: 2884352) Galano A, Vargas R, Martínez A (2010) Carotenoids can act as antioxidants by oxidizing the superoxide radical anion. Phys Chem Chem Phys 12(1):193–200. (PMID: 20024459) Geinisman Y, Detoledo-Morrell L, Morrell F, Heller RE (1995) Hippocampal markers of age-related memory dysfunction: behavioral, electrophysiological and morphological perspectives. Prog Neurobiol 45(3):223–252. (PMID: 7777673) Ghasemzadeh A, Ghasemzadeh N (2011) Flavonoids and phenolic acids: role and biochemical activity in plants and human. J Med Plants Res 5(31):6697–6703. Grimm S, Hoehn A, Davies KJ, Grune T (2011) Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res 45(1):73–88. (PMID: 20815785) Grune T, Shringarpure R, Sitte N, Davies K (2001) Age-related changes in protein oxidation and proteolysis in mammalian cells. J Gerontol Ser A 56(11):B459–B467. Hadad N, Levy R (2017) Combination of EPA with carotenoids and polyphenol synergistically attenuated the transformation of microglia to M1 phenotype via inhibition of NF-κB. Neuromol Med 19(2–3):436–451. Halliwell B, Chirico S (1993) Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 57(5):715S–725S. (PMID: 8475889) Hira S, Saleem U, Anwar F, Sohail MF, Raza Z, Ahmad B (2019) β-Carotene: a natural compound improves cognitive impairment and oxidative stress in a mouse model of streptozotocin-induced Alzheimer’s disease. Biomolecules 9(9):441. (PMID: 6769610) Holmes E, Bonner FW, Nicholson JK (1995) Comparative studies on the nephrotoxicity of 2- bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis). Arch Toxicol 70:89–95. (PMID: 8773180) Hua X, Lei M, Zhang Y, Ding J, Han Q, Hu G et al (2007) Long-term D-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer’s disease. Life Sci 80(20):1897–1905. (PMID: 17391708) Islam M, Alam F, Solayman M, Khalil M, Kamal MA, Gan SH (2016) Dietary phytochemicals: natural swords combating inflammation and oxidation-mediated degenerative diseases. Oxid Med Cell Longev. Kawakami K, Kadota J-i, Iida K, Shirai R, Abe K, Kohno S (1999) Reduced immune function and malnutrition in the elderly. Tohoku J Exp Med 187(2):157–171. (PMID: 10228987) Kingsley PB (1999) Signal intensities and T1 calculations in multiple-echo sequences with imperfect pulses. Concepts Magn Reson 11(1):29–49. Kızıl G, Kızıl M, Çeken B, Yavuz M, Demir H (2011) Protective ability of ethanol extracts of Hypericum scabrum L. and Hypericum retusum Aucher against the protein oxidation and DNA damage. Int J Food Prop 14(4):926–940. Klegeris A, Korkina LG, Greenfield SA (1995) Autoxidation of dopamine: a comparison of luminescent and spectrophotometric detection in basic solutions. Free Radic Biol Med 18(2):215–222. (PMID: 7744304) Krinsky NI (1989) Antioxidant functions of carotenoids. Free Radic Biol Med 7(6):617–635. (PMID: 2695406) Krinsky NI (2001) Carotenoids as antioxidants. Nutrition 17(10):815–817. (PMID: 11684386) Kumar A, Srikanta AH, Muthukumar S, Sukumaran U-K, Govindaswamy V (2011) Antioxidant and lipid peroxidation activities in rats fed with Aspergillus carbonarius carotenoid. Food Chem Toxicol 49(12):3098–3103. (PMID: 21925232) Kumar A, Srikanta AH, Peddha MS, Sukumaran U-K, Govindaswamy V (2012) A short-term toxicity study of Aspergillus carbonarius carotenoid. Int J Toxicol 31(2):158–165. (PMID: 22366116) Kumaresan N, Sanjay KR, Venkatesh KS, Kadeppagari R-K, Vijayalakshmi G, Umesh-Kumar S (2008) Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line. Appl Microbiol Biotechnol 80(3):467–473. (PMID: 18542946) Laemmli U (1970) SDS-page Laemmli method. Nature 227:680–685. (PMID: 5432063) Landrum JT (2013) Reactive oxygen and nitrogen species in biological systems: reactions and regulation by carotenoids. In: Carotenoids and human health. Springer, pp 57–101. Levine RL, Stadtman ER (2001) Oxidative modification of proteins during aging. Exp Gerontol 36(9):1495–1502. Lin J, Huang L, Yu J, Xiang S, Wang J, Zhang J et al (2016) Fucoxanthin, a marine carotenoid, reverses scopolamine-induced cognitive impairments in mice and inhibits acetylcholinesterase in vitro. Mar Drugs 14(4):67. (PMID: 4849071) Lin H-C, Lin M-H, Liao J-H, Wu T-H, Lee T-H, Mi F-L et al (2017) Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: insights into the molecular mechanism and inhibitory targets. J Agric Food Chem 65(1):51–59. (PMID: 27997180) Long J, Wang X, Gao H, Liu Z, Liu C, Miao M et al (2007) D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8(3):373–381. (PMID: 17473993) Meraz Rios MA, Toral-Rios D, Franco-Bocanegra D, Villeda-Hernández J, Campos-Peña V (2013) Inflammatory process in Alzheimer’s disease. Front Integr Nuerosci 7:59. Milatovic D, Gupta RC, Aschner M (2006) Anticholinesterase toxicity and oxidative stress. Sci World J 6:295–310. Min J-y, Min K-b (2014) Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer’s disease mortality in older adults. Dement Geriatr Cogn Disord 37(3–4):246–256. (PMID: 24247062) Moini M, Schultz CL, Mahmood H (2003) CE/electrospray ionization-MS analysis of underivatized d/l-amino acids and several small neurotransmitters at attomole levels through the use of 18-crown-6-tetracarboxylic acid as a complexation reagent/background electrolyte. Anal Chem 75(22):6282–6287. (PMID: 14616012) Molz P, Schröder N (2017) Potential therapeutic effects of lipoic acid on memory deficits related to aging and neurodegeneration. Front Pharmacol 8:849. (PMID: 293119125732919) Niranjan R (2014) The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson’s disease: focus on astrocytes. Mol Neurobiol 49(1):28–38. (PMID: 23783559) Olanow C (1993) A radical hypothesis for neurodegeneration. Trends Neurosci 16(11):439–444. (PMID: 7507613) Oliver CN, Ahn B-W, Moerman EJ, Goldstein S, Stadtman ER (1987) Age-related changes in oxidized proteins. J Biol Chem 262(12):5488–5491. (PMID: 3571220) Paradies G, Petrosillo G, Paradies V, Ruggiero FM (2011) Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin. Neurochem Int 58(4):447–457. (PMID: 21215780) Parrot S, Neuzeret P-C, Denoroy L (2011) A rapid and sensitive method for the analysis of brain monoamine neurotransmitters using ultra-fast liquid chromatography coupled to electrochemical detection. J Chromatogr B 879(32):3871–3878. Pow DV, Wright LL, Vaney DI (1995) The immunocytochemical detection of amino-acid neurotransmitters in paraformaldehyde-fixed tissues. J Neurosci Methods 56(2):115–123. (PMID: 7752677) Qingming Y, Xianhui P, Weibao K, Hong Y, Yidan S, Li Z et al (2010) Antioxidant activities of malt extract from barley (Hordeum vulgare L.) toward various oxidative stress in vitro and in vivo. Food Chem 118(1):84–89. Quantitative NMR Spectroscopy.dox 11/2017, University of Oxford. Sánchez-Moreno C, Plaza L, de Ancos B, Cano MP (2006) Nutritional characterisation of commercial traditional pasteurised tomato juices: carotenoids, vitamin C and radical-scavenging capacity. Food Chem 98(4):749–756. Sarubbo F, Ramis M, Aparicio S, Ruiz L, Esteban S, Miralles A et al (2015) Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats. Age 37(3):37. (PMID: 4404420) Shemyakov S (2001) Monoamine oxidase activity, lipid peroxidation, and morphological changes in human hypothalamus during aging. Bull Exp Biol Med 131(6):586–588. (PMID: 11586414) Sies H (2000) What is oxidative stress? In: Oxidative stress and vascular disease. Springer, pp 1–8. Wang J, Li L, Wang Z, Cui Y, Tan X, Yuan T et al (2018) Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. J Nutr Biochem 56:16–25. (PMID: 29454265) Wu W, Wang X, Xiang Q, Meng X, Peng Y, Du N et al (2014) Astaxanthin alleviates brain aging in rats by attenuating oxidative stress and increasing BDNF levels. Food function 5(1):158–166. (PMID: 24326685) Xavier AAO, Pérez-Gálvez A (2016) Carotenoids as a source of antioxidants in the diet. In: Carotenoids in nature. Springer, pp 359–375. Xian Y-F, Lin Z-X, Zhao M, Mao Q-Q, Ip S-P, Che C-T (2011) Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in mice. Planta Med 77(18):1977–1983. (PMID: 21858756) Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C (2003) Interaction between flavonoids and the blood–brain barrier: in vitro studies. J Neurochem 85(1):180–192. (PMID: 12641740) Youdim KA, Shukitt-Hale B, Joseph JA (2004) Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system. Free Radic Biol Med 37(11):1683–1693. (PMID: 15528027) Yu Y, Bai F, Wang W, Liu Y, Yuan Q, Qu S et al (2015) Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation. Pharmacol Biochem Behav 133:122–131. (PMID: 25871519) Zhang Y, Pi Z, Song F, Liu Z (2016) Ginsenosides attenuate D-galactose-and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer’s disease. J Ethnopharmacol 194:188–195. (PMID: 27612432) |
| معلومات مُعتمدة: | YSS/2015/000298 Science and Engineering Research Board |
| فهرسة مساهمة: | Keywords: Aging; Antiaging; Antioxidant; Carotenoids; Oxidative stress |
| المشرفين على المادة: | 0 (Antioxidants) 4C3C6403MU (Canthaxanthin) 4Y8F71G49Q (Malondialdehyde) EC 1.11.1.6 (Catalase) EC 1.11.1.9 (Glutathione Peroxidase) EC 1.15.1.1 (Superoxide Dismutase) X2RN3Q8DNE (Galactose) |
| SCR Organism: | Aspergillus carbonarius |
| تواريخ الأحداث: | Date Created: 20200914 Date Completed: 20210917 Latest Revision: 20210917 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10522-020-09898-4 |
| PMID: | 32926226 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-6768 |
|---|---|
| DOI: | 10.1007/s10522-020-09898-4 |