دورية أكاديمية
Partially saturated canthaxanthin alleviates aging-associated oxidative stress in D-galactose administered male wistar rats.
العنوان: | Partially saturated canthaxanthin alleviates aging-associated oxidative stress in D-galactose administered male wistar rats. |
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المؤلفون: | Mathimaran A; Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Vallam, Thanjavur, Tamil Nadu, India.; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Kumar A; Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Vallam, Thanjavur, Tamil Nadu, India. anbarasuk@pmu.edu., Prajapati G; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Ampapathi RS; Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India.; CSIR-Academy of Scientific and Innovative Research (CSIR-AcSIR), Ghaziabad, Uttar Pradesh, India., Bora HK; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India., Guha R; Laboratory Animal Facility, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh, India. rajdeep.guha@cdri.res.in.; CSIR-Academy of Scientific and Innovative Research (CSIR-AcSIR), Ghaziabad, Uttar Pradesh, India. rajdeep.guha@cdri.res.in. |
المصدر: | Biogerontology [Biogerontology] 2021 Feb; Vol. 22 (1), pp. 19-34. Date of Electronic Publication: 2020 Sep 14. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Dordrecht ; Boston : Kluwer Academic, c2000- |
مواضيع طبية MeSH: | Canthaxanthin* , Galactose*, Aging ; Animals ; Antioxidants/pharmacology ; Aspergillus ; Catalase/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation ; Male ; Malondialdehyde ; Oxidative Stress ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism |
مستخلص: | It has been earlier reported that partially saturated canthaxanthin (PSC) from Aspergillus carbonarius mutant is non-toxic, has anti-lipid peroxidation activity and can induce apoptosis in prostate cancer cell lines. In the present study, the antiaging effect of PSC was explored in D-galactose administered male wistar rats. 8-10 weeks old, male wistar rats were randomly divided into (i) Vehicle Control Group (VCG), (ii) Aged Control Group (ACG), (iii) Aged + α Lipoic Acid Group (ALG) and (iv) Aged + Partially saturated canthaxanthin Group (APG). Rats received D-galactose (300 mg /kg bwt/day; i.p.) alone (ACG) or together with PSC (APG) (20 mg/kg bwt/day; oral) and α Lipoic Acid (ALG) (80 mg/kg bwt/day; oral) for 10 weeks. Rats in VCG were injected with the same volume of physiological saline (i.p.) and fed with olive oil (vehicle). In vitro protein oxidation and DNA oxidation inhibition, in vivo malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities were determined. In addition, brain neurotransmitters, dopamine and serotonin were estimated by NMR. PSC treatment showed inhibition against protein and DNA oxidation. PSC effectively improved D-galactose induced aging rats by inducing a protective effect through up-regulation of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and brain neurotransmitters and downregulated malondialdehyde (MDA) and monoamineoxidase (MAO) levels. Thus, PSC appears to be a functional compound having antioxidant and antiaging properties. |
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معلومات مُعتمدة: | YSS/2015/000298 Science and Engineering Research Board |
فهرسة مساهمة: | Keywords: Aging; Antiaging; Antioxidant; Carotenoids; Oxidative stress |
المشرفين على المادة: | 0 (Antioxidants) 4C3C6403MU (Canthaxanthin) 4Y8F71G49Q (Malondialdehyde) EC 1.11.1.6 (Catalase) EC 1.11.1.9 (Glutathione Peroxidase) EC 1.15.1.1 (Superoxide Dismutase) X2RN3Q8DNE (Galactose) |
SCR Organism: | Aspergillus carbonarius |
تواريخ الأحداث: | Date Created: 20200914 Date Completed: 20210917 Latest Revision: 20210917 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s10522-020-09898-4 |
PMID: | 32926226 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-6768 |
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DOI: | 10.1007/s10522-020-09898-4 |