دورية أكاديمية
A double-blind placebo controlled trial on effectiveness of prophylactic dexamethasone for preventing post- dural puncture headache after spinal anesthesia for cesarean section.
| العنوان: | A double-blind placebo controlled trial on effectiveness of prophylactic dexamethasone for preventing post- dural puncture headache after spinal anesthesia for cesarean section. |
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| المؤلفون: | Okpala BC; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Eleje GU; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ikechebelu JI; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ofojebe CJ; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Awka, Nigeria.; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Ejikeme TB; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Nwachukwu CE; Department of Anesthesiology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Okpala AN; Department of Family Medicine, Federal Medical Centre, Owerri, Nigeria. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Sep; Vol. 35 (17), pp. 3407-3412. Date of Electronic Publication: 2020 Sep 14. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Anesthesia, Spinal*/adverse effects , Post-Dural Puncture Headache*/epidemiology , Post-Dural Puncture Headache*/etiology , Post-Dural Puncture Headache*/prevention & control, Cesarean Section/adverse effects ; Dexamethasone/therapeutic use ; Double-Blind Method ; Female ; Humans ; Nausea ; Pregnancy ; Spinal Puncture/adverse effects |
| مستخلص: | Aim: To determine the effect of dexamethasone in reducing post-dural puncture headache (PDPH) after spinal anesthesia for cesarean section (CS). Methods: A double blind placebo controlled randomized trial of parturients undergoing CS under spinal anesthesia was conducted. Participants ( n = 192) were randomly (1:1 ratio) given either 2mls (8 mg) of dexamethasone ( n = 96) intravenously or 2mls of normal saline ( n = 96) intravenously as placebo after clamping the umbilical cord. Visual analogue scale was used to assess the incidence and severity of PDPH on the first and fourth post-operative days. The primary outcome measure was incidence of PDPH while the secondary outcome measure was incidence of nausea and vomiting. Analysis was by intention-to-treat. Results: Baseline socio-demographic and clinical variables were similar between the two groups and none of the women was lost to follow up. The incidence of PDPH (8.3% vs 25.0%; p = .002) and nausea (11.5% vs 25.0%; p = .015) were significantly lower in dexamethasone group. The severity of headache in the control groups were statistically higher on the first ( p < .001) and fourth ( p < .001) post-operative days. . Conclusion: Prophylactic dexamethasone reduces the incidence and severity of PDPH on both the first and fourth post-operative day after spinal anesthesia for CS. There was also an improvement on the incidence of nausea on the dexamethasone group compared to control. |
| فهرسة مساهمة: | Keywords: Cesarean section; dexamethasone; post-dural puncture headache; spinal anesthesia |
| المشرفين على المادة: | 7S5I7G3JQL (Dexamethasone) |
| تواريخ الأحداث: | Date Created: 20200915 Date Completed: 20220708 Latest Revision: 20220708 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14767058.2020.1818719 |
| PMID: | 32928014 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2020.1818719 |