دورية أكاديمية
A Single-Center Assessment of Delayed Graft Function in Recipients of Simultaneous Liver and Kidney Transplant.
| العنوان: | A Single-Center Assessment of Delayed Graft Function in Recipients of Simultaneous Liver and Kidney Transplant. |
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| المؤلفون: | Aziz F; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Gardezi A; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Muth B; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Blazel J; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Garg N; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Mohammed M; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Mezrich J; Division of Transplantation, Department of Surgery, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Djamali A; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.; Division of Transplantation, Department of Surgery, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Mandelbrot D; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA., Parajuli S; Division of Nephrology, Department of Medicine, 5228University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA. |
| المصدر: | Progress in transplantation (Aliso Viejo, Calif.) [Prog Transplant] 2020 Dec; Vol. 30 (4), pp. 342-348. Date of Electronic Publication: 2020 Sep 15. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 100909380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2164-6708 (Electronic) Linking ISSN: 15269248 NLM ISO Abbreviation: Prog Transplant |
| أسماء مطبوعة: | Publication: 2016- : Thousand Oaks, California : Sage Original Publication: Aliso Viejo, CA : Published for NATCO by InnoVision Communications, Inc, c2000- |
| مواضيع طبية MeSH: | Comorbidity*, Delayed Graft Function/*physiopathology , Graft Rejection/*physiopathology , Kidney Failure, Chronic/*surgery , Kidney Transplantation/*adverse effects , Liver Failure, Acute/*surgery , Liver Transplantation/*adverse effects , Transplantation, Homologous/*adverse effects, Adult ; Age Factors ; Aged ; Delayed Graft Function/mortality ; Female ; Graft Rejection/mortality ; Humans ; Incidence ; Kidney Failure, Chronic/epidemiology ; Kidney Transplantation/mortality ; Liver Failure, Acute/epidemiology ; Liver Transplantation/mortality ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors ; Sex Factors ; Transplantation, Homologous/mortality ; Wisconsin/epidemiology |
| مستخلص: | Background: The effects of delayed graft function on long-term kidney allograft outcomes are poorly defined among simultaneous liver and kidney transplant recipients. Methods: We analyzed data of all simultaneous liver and kidney recipients transplanted at the University of Wisconsin between 2010 and 2017. Risk factors for the development of delayed graft function, kidney graft failure, and patient mortality were outcomes of interest. Results: There were a total of 60 simultaneous liver and kidney recipients; 28 (47%) had delayed graft function. After adjustment for multiple variables, we found that pretransplant dialysis >6 weeks (hazard ratio [HR] = 5.6, 95% CI: 1.23-25.59, P = .02), pretransplant albumin <3 g/dL (HR = 5.75, 95% CI: 1.76-16.94, P = .003), and presence of pretransplant diabetes (HR = 2.5, 95% CI: 0.97-4.77, P = .05) were significantly associated with delayed graft function. Multivariate analysis showed that pretransplant albumin <3 (HR = 4.86, 95% CI: 1.07-22.02, P = .02) was associated with a higher risk of all-cause kidney allograft failure, whereas the duration of delayed graft function (HR = 1.07 per day, 95% CI: 1.01-1.14, P = .01) was associated with a higher risk of death-censored kidney allograft failure. The presence of delayed graft function was not associated with all-cause or death-censored kidney or liver allograft failure. Similarly, the presence of delayed graft function was not associated with patient mortality. Conclusion: The incidence of delayed graft function was high in simultaneous liver and kidney recipients. However, with appropriate management, delayed graft function may not have a negative impact on patient or kidney allograft survival. |
| فهرسة مساهمة: | Keywords: delayed graft function; factors; outcomes; simultaneous liver and kidney transplant |
| تواريخ الأحداث: | Date Created: 20200915 Date Completed: 20211021 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/1526924820958155 |
| PMID: | 32930044 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2164-6708 |
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| DOI: | 10.1177/1526924820958155 |