دورية أكاديمية
Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution.
| العنوان: | Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution. |
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| المؤلفون: | Sepulchre E; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., Pittie G; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., Stojkovic V; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., Haesbroek G; Department of Mathematics, University of Liège, Liège, Belgium., Crama Y; HEC Liège, Management School of the University of Liège, Liège, Belgium., Schyns M; HEC Liège, Management School of the University of Liège, Liège, Belgium., Paridaens H; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., de Marchin J; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., Degesves S; Department of Emergencies, CHR Citadelle, Liège, Belgium., Biemar C; Department of Emergencies, CHR Citadelle, Liège, Belgium., Boccar S; Department of Intensive Care, CHR Citadelle, Liège, Belgium., Senterre JM; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium., Minon JM; Department of Laboratory Medicine, CHR Citadelle, Liège, Belgium. |
| المصدر: | Acta clinica Belgica [Acta Clin Belg] 2022 Apr; Vol. 77 (2), pp. 261-267. Date of Electronic Publication: 2020 Sep 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2295-3337 (Electronic) Linking ISSN: 17843286 NLM ISO Abbreviation: Acta Clin Belg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Abingdon : Taylor & Francis Original Publication: Bruxelles : Acta Clinica Belgica |
| مواضيع طبية MeSH: | COVID-19*/diagnosis, Humans ; Laboratories ; Male ; Pandemics ; Retrospective Studies ; SARS-CoV-2 |
| مستخلص: | Background: The aim of this study was to identify early clinical and laboratory predictive factors of a severe coronavirus disease 2019 (COVID-19). Methods: A retrospective study was conducted on adult patients hospitalized for COVID-19 in our hospital. Diagnosis was based on a positive real-time reverse transcription-polymerase chain reaction (RT-PCR) on nasopharyngeal samples. The cohort was divided into two groups, i.e. a favorable evolution (FE) group and an unfavorable evolution (UFE) group, including intensive care unit (ICU) and deceased patients.Results: A total of 198 patients were enrolled in the study, with 138 FE (70%) and 60 UFE (30%). Older age, male gender, comorbidities and dyspnea at admission constituted significantly worse prognosis factors. Among laboratory features, lymphocyte and platelet counts as well as corrected glomerular filtration rate were significantly lower in UFE patients, while neutrophil to lymphocyte ratio, inflammation biomarkers, creatinine, aspartate aminotransferase, lactate dehydrogenase (LDH), glycemia and D-dimer were significantly higher. Procalcitonin and LDH appeared as the most accurate variables according to receiver operating characteristic curves. Conclusions: This Belgian study revealed clinical and laboratory features able to predict high risk of ICU requirement, or even death, at admission time. These results provide a potential tool for patient's triage in a context of pandemic. Abbreviations : COVID-19: coronavirus disease 2019; ARDS: acute respiratory distress syndrome; DIC: disseminated intravascular coagulopathy; MOF: multi-organ failure; RT-PCR: real-time reverse transcription-polymerase chain reaction; UFE: unfavorable evolution; ICU: intensive care unit; EDTA: ethylenediamine tetraacetic acid; WBC: white blood cell count; Hb: hemoglobin level; PCT: procalcitonin; Na: sodium; K: potassium; PT: total protein, CRP: c-reactive protein; Cr: creatinine; ALAT: alanine aminotransferase; ALAT: aspartate aminotransferase; TB: total bilirubin, LDH: lactate dehydrogenase, FERR: ferritin; hs-Tnt: high sensitive-troponin T; cGFR: corrected glomerular filtration rate; QR: quick ratio; DDIM: D-dimer; FIB: fibrinogen; SD: standard deviation; IQR: interquartile ranges; ROC: receiver operating characteristics; ECMO: extracorporeal membrane oxygenation; NLR: neutrophil to lymphocyte ratio; AUC: area under the curve; BMI: body mass index. |
| فهرسة مساهمة: | Keywords: COVID-19; biological features; coronavirus; laboratory tests; prognosis |
| تواريخ الأحداث: | Date Created: 20200916 Date Completed: 20220308 Latest Revision: 20220502 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/17843286.2020.1822078 |
| PMID: | 32935644 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2295-3337 |
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| DOI: | 10.1080/17843286.2020.1822078 |