دورية أكاديمية
Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.
| العنوان: | Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19. |
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| المؤلفون: | Mann ER; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.; Maternal and Fetal Health Centre, Division of Developmental Biology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 5th Floor St. Mary's Hospital, Oxford Road, Manchester M13 9WL, UK., Menon M; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Knight SB; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.; Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK., Konkel JE; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Jagger C; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Shaw TN; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Krishnan S; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Rattray M; Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK., Ustianowski A; Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK.; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Bakerly ND; Respiratory Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK., Dark P; Intensive Care Department, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, UK., Lord G; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK., Simpson A; Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK., Felton T; Division of Infection, Immunity and Respiratory Medicine, Manchester NIHR BRC, Education and Research Centre, Wythenshawe Hospital, UK., Ho LP; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford., Feldmann M; Kennedy Institute of Rheumatology, Botnar Research Centre, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Science, Windmill Rd, Headington, Oxford, OX3 7LD, UK., Grainger JR; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk., Hussell T; Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK. tracy.hussell@manchester.ac.uk john.grainger-2@manchester.ac.uk. |
| مؤلفون مشاركون: | NIHR Respiratory TRC,, CIRCO, |
| المصدر: | Science immunology [Sci Immunol] 2020 Sep 17; Vol. 5 (51). |
| نوع المنشور: | Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : American Association for the Advancement of Science, [2016]- |
| مواضيع طبية MeSH: | Immunity, Innate*, Betacoronavirus/*immunology , Coronavirus Infections/*immunology , Monocytes/*immunology , Pneumonia, Viral/*immunology, Adult ; Aged ; Biomarkers/blood ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Cyclooxygenase 2/immunology ; Cyclooxygenase 2/metabolism ; Disease Progression ; Female ; Host Microbial Interactions/immunology ; Humans ; Inflammation Mediators/blood ; Inflammation Mediators/immunology ; Ki-67 Antigen/immunology ; Ki-67 Antigen/metabolism ; Longitudinal Studies ; Male ; Middle Aged ; Monocytes/metabolism ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Prospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; United Kingdom/epidemiology |
| مستخلص: | COVID-19 pathogenesis is associated with an exaggerated immune response. However, the specific cellular mediators and inflammatory components driving diverse clinical disease outcomes remain poorly understood. We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14 + monocyte phenotype and function. Modified features of CD14 + monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, as well as enhanced expression of the cell cycle marker K (Copyright © 2020, American Association for the Advancement of Science.) |
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| معلومات مُعتمدة: | MR/R00191X/1 United Kingdom MRC_ Medical Research Council; 20606/Z/17/Z United Kingdom WT_ Wellcome Trust; 202865/Z/16/Z United Kingdom WT_ Wellcome Trust; 106898/A/15/Z United Kingdom WT_ Wellcome Trust; MR/L011840/1 United Kingdom MRC_ Medical Research Council; 21927 United Kingdom VAC_ Versus Arthritis; United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Investigator: A Horsley; T Harrison; J Porter; R Djukanovic; S Marciniak; C Brightling; LP Ho; L McGarvey; J Davies; R Ahmed; HA Shuwa; M Avery; K Birchall; O Brand; E Charsley; A Chenery; C Chew; R Clark; E Connolly; K Connolly; S Dawson; L Durrans; H Durrington; J Egan; C Fox; H Francis; M Franklin; S Glasgow; N Godfrey; KJ Gray; S Grundy; J Guerin; P Hackney; M Iqbal; C Hayes; E Hardy; J Harris; A John; B Jolly; V Kästele; S Khan; G Lindergard; S Lui; L Lowe; AG Mathioudakis; FA McClure; J Mitchell; C Moizer; K Moore; DJ Morgan; S Moss; SM Baker; R Oliver; G Padden; C Parkinson; L Pearmain; M Phuycharoen; A Saha; B Salcman; NA Scott; S Sharma; J Shaw; J Shaw; E Shepley; L Smith; S Stephan; R Stephens; G Tavernier; R Tudge; L Wareing; R Warren; T Williams; L Willmore; M Younas |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Inflammation Mediators) 0 (Ki-67 Antigen) 0 (MKI67 protein, human) EC 1.14.99.1 (Cyclooxygenase 2) EC 1.14.99.1 (PTGS2 protein, human) |
| تواريخ الأحداث: | Date Created: 20200918 Date Completed: 20200929 Latest Revision: 20220129 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7857390 |
| DOI: | 10.1126/sciimmunol.abd6197 |
| PMID: | 32943497 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.abd6197 |