دورية أكاديمية
أعرض في EDS

D-CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System-Based Versus Community-Based Dementia Care Versus Usual Dementia Care.

التفاصيل البيبلوغرافية
العنوان: D-CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System-Based Versus Community-Based Dementia Care Versus Usual Dementia Care.
المؤلفون: Reuben DB; Department of Medicine, Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Gill TM; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Stevens A; Department of Medicine, Baylor Scott & White Health, Temple, Texas, USA., Williamson J; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Volpi E; Department of Internal Medicine, Division of Geriatrics, University of Texas, Medical Branch, Galveston, Texas, USA., Lichtenstein M; Department of Neurology, Geisinger Health, Wilkes Barre, Pennsylvania, USA., Jennings LA; Department of Medicien, Reynolds Section of Geriatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Tan Z; Department of Medicine, Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Evertson L; Department of Medicine, Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Bass D; Center for Research and Education, Benjamin Rose Institute on Aging, Cleveland, Ohio, USA., Weitzman L; Center for Research and Education, Benjamin Rose Institute on Aging, Cleveland, Ohio, USA., Carnie M; Center for Patients and Families, Brigham and Women's Hospital, Boston, Massachusetts, USA., Wilson N; Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Araujo K; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Charpentier P; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Meng C; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Greene EJ; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Dziura J; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA., Liu J; Pardee RAND Graduate School, Santa Monica, California, USA., Unger E; Department of Medicine, Division of Geriatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, USA., Yang M; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Currie K; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Lenoir KM; Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA., Green AS; Department of Medicine, Baylor Scott & White Health, Temple, Texas, USA., Abraham S; Department of Medicine, Baylor Scott & White Health, Temple, Texas, USA., Vernon A; Department of Medicine, Baylor Scott & White Health, Temple, Texas, USA., Samper-Ternent R; Department of Internal Medicine, Division of Geriatrics, University of Texas, Medical Branch, Galveston, Texas, USA., Raji M; Department of Internal Medicine, Division of Geriatrics, University of Texas, Medical Branch, Galveston, Texas, USA., Hirst RM; Department of Internal Medicine, Division of Geriatrics, University of Texas, Medical Branch, Galveston, Texas, USA., Galloway R; Department of Internal Medicine, Division of Geriatrics, University of Texas, Medical Branch, Galveston, Texas, USA., Finney GR; Department of Neurology, Geisinger Health, Wilkes Barre, Pennsylvania, USA., Ladd I; Department of Neurology, Geisinger Health, Wilkes Barre, Pennsylvania, USA., Rahm AK; Department of Neurology, Geisinger Health, Wilkes Barre, Pennsylvania, USA., Borek P; Department of Neurology, Geisinger Health, Wilkes Barre, Pennsylvania, USA., Peduzzi P; Department of Internal Medicine, Section of Geriatrics, Yale University, New Haven, Connecticut, USA.
المصدر: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2020 Nov; Vol. 68 (11), pp. 2492-2499. Date of Electronic Publication: 2020 Oct 06.
نوع المنشور: Clinical Trial Protocol; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 7503062 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-5415 (Electronic) Linking ISSN: 00028614 NLM ISO Abbreviation: J Am Geriatr Soc Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Blackwell Science
Original Publication: New York [etc.]
مواضيع طبية MeSH: Alzheimer Disease/*therapy , Caregiver Burden/*psychology , Community Health Services/*organization & administration , Comprehensive Health Care/*methods, Aged ; Cost-Benefit Analysis ; Female ; Humans ; Male ; Multicenter Studies as Topic ; Pragmatic Clinical Trials as Topic ; Quality Improvement ; Quality of Life
مستخلص: Background/objectives: Although several approaches have been developed to provide comprehensive care for persons living with dementia (PWD) and their family or friend caregivers, the relative effectiveness and cost effectiveness of community-based dementia care (CBDC) versus health system-based dementia care (CBDC) and the effectiveness of both approaches compared with usual care (UC) are unknown.
Design: Pragmatic randomized three-arm superiority trial. The unit of randomization is the PWD/caregiver dyad.
Setting: Four clinical trial sites (CTSs) based in academic and clinical health systems.
Participants: A total of 2,150 English- or Spanish-speaking PWD who are not receiving hospice or residing in a nursing home and their caregivers.
Interventions: Eighteen months of (1) HSDC provided by a nurse practitioner or physician's assistant dementia care specialist who works within the health system, or (2) CBDC provided by a social worker or nurse care consultant who works at a community-based organization, or (3) UC with as needed referral to the Alzheimer's Association Helpline.
Measurements: Primary outcomes: PWD behavioral symptoms and caregiver distress as measured by the Neuropsychiatric Inventory Questionnaire (NPI-Q) Severity and Modified Caregiver Strain Index scales.
Secondary Outcomes: NPI-Q Distress, caregiver unmet needs and confidence, and caregiver depressive symptoms. Tertiary outcomes: PWD long-term nursing home placement rates, caregiver-reported PWD functional status, cognition, goal attainment, "time spent at home," Dementia Burden Scale-Caregiver, a composite measure of clinical benefit, Quality of Life of persons with dementia, Positive Aspects of Caregiving, and cost effectiveness using intervention costs and Medicare claims.
Results: The results will be reported in the spring of 2024.
Conclusion: D-CARE will address whether emphasis on clinical support and tighter integration with other medical services has greater benefit than emphasis on social support that is tied more closely to community resources. It will also assess the effectiveness of both interventions compared with UC and will evaluate the cost effectiveness of each intervention.
(© 2020 The American Geriatrics Society.)
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معلومات مُعتمدة: R01 AG061078 United States AG NIA NIH HHS; PCS-2017C1-6534 United States PCORI Patient-Centered Outcomes Research Institute; UL1 TR001863 United States TR NCATS NIH HHS; P30 AG049638 United States AG NIA NIH HHS; United States NH NIH HHS; P30 AG024832 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Alzheimer's disease; care coordination; dementia; pragmatic trials
تواريخ الأحداث: Date Created: 20200919 Date Completed: 20210331 Latest Revision: 20221028
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8086629
DOI: 10.1111/jgs.16862
PMID: 32949145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-5415
DOI:10.1111/jgs.16862