دورية أكاديمية
Ecological divergence and hybridization of Neotropical Leishmania parasites.
| العنوان: | Ecological divergence and hybridization of Neotropical Leishmania parasites. |
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| المؤلفون: | Van den Broeck F; Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium; fvandenbroeck@gmail.com jcdujardin@itg.be.; Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium., Savill NJ; Institute of Immunology and Infection Research, University of Edinburgh, EH8 9YL Edinburgh, United Kingdom., Imamura H; Centre of Medical Genetics, Universitair Ziekenhuis Brussel, 1000 Brussels, Belgium., Sanders M; Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton, United Kingdom., Maes I; Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium., Cooper S; Institute of Immunology and Infection Research, University of Edinburgh, EH8 9YL Edinburgh, United Kingdom., Mateus D; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT London, United Kingdom., Jara M; Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium.; Instituto de Medicina Tropical Alexander von Humboldt, Cayetano Heredia University, 15000 Lima, Peru., Adaui V; Instituto de Medicina Tropical Alexander von Humboldt, Cayetano Heredia University, 15000 Lima, Peru., Arevalo J; Instituto de Medicina Tropical Alexander von Humboldt, Cayetano Heredia University, 15000 Lima, Peru., Llanos-Cuentas A; Instituto de Medicina Tropical Alexander von Humboldt, Cayetano Heredia University, 15000 Lima, Peru., Garcia L; Instituto de Investigación Biomédicas e Investigación Social, Universidad Mayor de San Simon, 06651 Cochabamba, Bolivia., Cupolillo E; Leishmaniasis Research Laboratory, Instituto Oswaldo Cruz, 21040-900 Rio de Janeiro, Brazil., Miles M; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, WC1E 7HT London, United Kingdom., Berriman M; Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton, United Kingdom., Schnaufer A; Institute of Immunology and Infection Research, University of Edinburgh, EH8 9YL Edinburgh, United Kingdom., Cotton JA; Parasite Genomics Group, Wellcome Sanger Institute, CB10 Hinxton, United Kingdom., Dujardin JC; Department of Biomedical Sciences, Institute of Tropical Medicine, 2000 Antwerp, Belgium; fvandenbroeck@gmail.com jcdujardin@itg.be.; Department of Biomedical Sciences, University of Antwerp, 2000 Antwerp, Belgium. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 06; Vol. 117 (40), pp. 25159-25168. Date of Electronic Publication: 2020 Sep 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Genome, Mitochondrial/*genetics , Host-Parasite Interactions/*genetics , Leishmania braziliensis/*genetics , Leishmaniasis, Cutaneous/*genetics, Ecosystem ; Forests ; Genetic Speciation ; Humans ; Leishmania braziliensis/pathogenicity ; Leishmaniasis, Cutaneous/epidemiology ; Leishmaniasis, Cutaneous/parasitology ; Peru/epidemiology ; Phylogeography |
| مستخلص: | The tropical Andes are an important natural laboratory to understand speciation in many taxa. Here we examined the evolutionary history of parasites of the Leishmania braziliensis species complex based on whole-genome sequencing of 67 isolates from 47 localities in Peru. We first show the origin of Andean Leishmania as a clade of near-clonal lineages that diverged from admixed Amazonian ancestors, accompanied by a significant reduction in genome diversity and large structural variations implicated in host-parasite interactions. Within the Andean species, patterns of population structure were strongly associated with biogeographical origin. Molecular clock and ecological niche modeling suggested that the history of diversification of the Andean lineages is limited to the Late Pleistocene and intimately associated with habitat contractions driven by climate change. These results suggest that changes in forestation over the past 150,000 y have influenced speciation and diversity of these Neotropical parasites. Second, genome-scale analyses provided evidence of meiotic-like recombination between Andean and Amazonian Leishmania species, resulting in full-genome hybrids. The mitochondrial genome of these hybrids consisted of homogeneous uniparental maxicircles, but minicircles originated from both parental species. We further show that mitochondrial minicircles-but not maxicircles-show a similar evolutionary pattern to the nuclear genome, suggesting that compatibility between nuclear-encoded mitochondrial genes and minicircle-encoded guide RNA genes is essential to maintain efficient respiration. By comparing full nuclear and mitochondrial genome ancestries, our data expand our appreciation on the genetic consequences of diversification and hybridization in parasitic protozoa. Competing Interests: The authors declare no competing interest. (Copyright © 2020 the Author(s). Published by PNAS.) |
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| معلومات مُعتمدة: | United Kingdom Wellcome Trust; MR/L019701/1 United Kingdom MRC_ Medical Research Council; 206194 United Kingdom WT_ Wellcome Trust; United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| فهرسة مساهمة: | Keywords: ecological speciation; interspecific hybridization; population genomics; speciation genomics; vector-borne disease |
| تواريخ الأحداث: | Date Created: 20200922 Date Completed: 20201124 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7547230 |
| DOI: | 10.1073/pnas.1920136117 |
| PMID: | 32958676 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1920136117 |