دورية أكاديمية

Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming.

التفاصيل البيبلوغرافية
العنوان: Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming.
المؤلفون: Bae-Gartz I; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany. inga.bae-gartz@uk-koeln.de., Kasper P; Department of Gastroenterology and Hepatology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Großmann N; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Breuer S; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Janoschek R; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Kretschmer T; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Appel S; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Schmitz L; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Vohlen C; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Quaas A; Department of Pathology, University Hospital of Cologne, Cologne, Germany., Schweiger MR; Translational Epigenetics and Tumor Genetic, University Hospital of Cologne, Cologne, Germany., Grimm C; Translational Epigenetics and Tumor Genetic, University Hospital of Cologne, Cologne, Germany., Fischer A; iCoder, Potsdam, Germany., Ferrari N; Cologne Center for Prevention in Childhood and Youth / Heart Center Cologne, University Hospital of Cologne, Cologne, Germany.; Institute of Movement and Neuroscience, Department of Movement and Health Promotion, German Sport University, Cologne, Germany., Graf C; Institute of Movement and Neuroscience, Department of Movement and Health Promotion, German Sport University, Cologne, Germany., Frese CK; Proteomics Core Facility, CECAD Research Center, University Hospital of Cologne, Cologne, Germany.; Max-Planck-Unit for the Science of Pathogens, Charité University Medicine Berlin, Berlin, Germany., Lang S; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Demir M; Department of Hepatology and Gastroenterology, Charité Campus Mitte and Campus Virchow Clinic, Charité University Medicine Berlin, Berlin, Germany., Schramm C; Department of Gastroenterology and Hepatology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Fink G; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Goeser T; Department of Gastroenterology and Hepatology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Dötsch J; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany., Hucklenbruch-Rother E; Department of Pediatrics and Adolescent Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Robert-Koch Str. 16, Building 44a, 50931, Cologne, Germany.
المصدر: Scientific reports [Sci Rep] 2020 Sep 22; Vol. 10 (1), pp. 15424. Date of Electronic Publication: 2020 Sep 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Liver/*metabolism , Non-alcoholic Fatty Liver Disease/*metabolism , Non-alcoholic Fatty Liver Disease/*prevention & control , Physical Conditioning, Animal/*physiology , Prenatal Exposure Delayed Effects/*metabolism , Prenatal Exposure Delayed Effects/*prevention & control, AMP-Activated Protein Kinases/metabolism ; Animals ; Body Weight/physiology ; Diet, High-Fat/adverse effects ; Female ; Liver/physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/physiopathology ; Obesity/metabolism ; Obesity/physiopathology ; PPAR alpha/metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects/physiopathology ; Signal Transduction/physiology ; Weight Gain/physiology
مستخلص: Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, and it remains unclear whether protective effects on hepatic metabolism are already seen in the offspring early life. This study aimed at determining the effects of ME during pregnancy on offspring body composition and development of NAFLD while focusing on proteomic-based analysis of the hepatic energy metabolism during developmental organ programming in early life. Under an obesogenic high-fat diet (HFD), male offspring of exercised C57BL/6J-mouse dams were protected from body weight gain and NAFLD in adulthood (postnatal day (P) 112). This was associated with a significant activation of hepatic AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARα) and PPAR coactivator-1 alpha (PGC1α) signaling with reduced hepatic lipogenesis and increased hepatic β-oxidation at organ programming peak in early life (P21). Concomitant proteomic analysis revealed a characteristic hepatic expression pattern in offspring as a result of ME with the most prominent impact on Cholesterol 7 alpha-hydroxylase (CYP7A1). Thus, ME may offer protection against offspring HFD-induced NAFLD by shaping hepatic proteomics signature and metabolism in early life. The results highlight the potential of exercise during pregnancy for preventing the early origins of NAFLD.
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المشرفين على المادة: 0 (PPAR alpha)
EC 2.7.11.31 (AMP-Activated Protein Kinases)
تواريخ الأحداث: Date Created: 20200923 Date Completed: 20201217 Latest Revision: 20210922
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7508970
DOI: 10.1038/s41598-020-72022-6
PMID: 32963289
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-72022-6