دورية أكاديمية
أعرض في EDS

Clinical application of fish-oil intravenous lipid emulsion in adult home parenteral nutrition patients.

التفاصيل البيبلوغرافية
العنوان: Clinical application of fish-oil intravenous lipid emulsion in adult home parenteral nutrition patients.
المؤلفون: Mundi MS; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA., Bonnes SL; Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Salonen BR; Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., McMahon MM; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA., Martindale R; Division of Gastrointestinal and General Surgery, Oregon Health Science University, Portland, Oregon, USA., Hurt RT; Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.; Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
المصدر: Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition [Nutr Clin Pract] 2021 Aug; Vol. 36 (4), pp. 839-852. Date of Electronic Publication: 2020 Sep 24.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8606733 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1941-2452 (Electronic) Linking ISSN: 08845336 NLM ISO Abbreviation: Nutr Clin Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : [Hoboken, NJ] : Wiley
Original Publication: [Baltimore, Md. : Williams & Wilkins, c1986-
مواضيع طبية MeSH: Intestinal Diseases*/therapy , Parenteral Nutrition, Home*/adverse effects, Adult ; Child ; Energy Intake ; Fat Emulsions, Intravenous ; Female ; Fish Oils ; Humans ; Male ; Middle Aged ; Soybean Oil
مستخلص: Background: High-ω-6 polyunsaturated fatty acids (PUFAs) are noted to contribute to development of intestinal failure-associated liver disease (IFALD) in home parenteral nutrition (HPN). Fish oil (FO) has been added to latest generation of lipid injectable emulsion (ILE) to increase ω-3:ω-6 PUFA ratio; however, appropriate dose of FO to treat IFALD is unknown.
Methods: After approval of exclusive FO ILE in the US for pediatric patients, we noted 2 adult patients with ongoing IFALD despite transition to mixed-oil (MO) ILE. They were transitioned to off-label FO ILE after review of literature regarding use of FO ILE in adult HPN patients was conducted to guide management.
Results: The first case involves a 40-year-old female receiving HPN with IFALD refractory to MO ILE. MO ILE (with 15% FO) was provided at 50 g/d for 3 d/wk and combined with FO ILE at 50 g/d for 4 d/wk. This combination resulted in improvement in liver studies and allowed for decrease in dextrose calories. The second case involves a 49-year-old male receiving HPN (secondary to complications of necrotizing pancreatitis) who developed IFALD. FO ILE was used as the sole source of lipids and led to improvement in liver function tests. No evidence of essential fatty acid deficiency was found in either case.
Conclusions: Current case presentations and review of literature support the use of FO ILE to increase ω-3 PUFAs in patients with IFALD refractory to MO ILE. Additional research is necessary to delineate the dose of FO ILE necessary to achieve benefit.
(© 2020 American Society for Parenteral and Enteral Nutrition.)
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فهرسة مساهمة: Keywords: fish oil; home parenteral nutrition; intestinal failure; intravenous fat emulsions; lipid emulsions; liver function tests
المشرفين على المادة: 0 (Fat Emulsions, Intravenous)
0 (Fish Oils)
8001-22-7 (Soybean Oil)
تواريخ الأحداث: Date Created: 20200924 Date Completed: 20210831 Latest Revision: 20210831
رمز التحديث: 20240628
DOI: 10.1002/ncp.10581
PMID: 32970359
قاعدة البيانات: MEDLINE
الوصف
تدمد:1941-2452
DOI:10.1002/ncp.10581